Complex application of certain micronatrients in men with androgen deficiency and pathosprimes

A. S. Minukhin, V. A. Bondarenko, N. M. Kononenko


A complex approach was made for the deactivation of deuterine micronutrients, which include antioxidant and metabolic metabolism, in individuals with androgen deficiency and idiopathic pathospermia. It has been shown that is using the complex preparation «FEROLL» for 60 days leads to increase the parameters of the spermogram to normal values on the background of normal androgen levels of blood in these patients.


androgen deficiency, micronutrient, pathospermia, testosterone

Full Text:



Wong W.Y., Thomas C.M.G., Merkus J.M. et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertility and Sterility. 2000. Vol. 73, № 3. Р. 435-442.

Purvis K., Christiansen E. Male infertility: current concepts. Ann. Med. 1992. Vol. 24, № 4. Р. 258-272.

Hwang K., Walters R. C., Lipshultz L. I. Contemporary concepts in the еvaluation and management of male infertility. Nat. Rev. Urol. 2011. Vol. 8, № 2. Р. 86-94.

Tremellen K. Oxidative stress and male infertility - a clinical perspective. Human Reproduction Update. 2008. Vol. 14, № 3. Р. 243-258.

Begumi H., Moniruddin A. B. M., AHAR K. Environmental and nutritional aspect in male infertility. J. Medicine. 2009. Vol. 10. P. 16-19.

Esteves S.A., Agarwal A. Novel Concepts in Male Infertility. International Braz. J. Urol. 2011. Vol. 37, № 1. Р. 5-15.

Mendiola J., Torres-Cantero A. M., Vioque J. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertility and Sterility. 2010. Vol. 93 (4). P. 1128-1133.

Nabil H., Moemen L. A., Abu Elela M. H. Studying the Levels of Malondialdehyde and Antioxidant Parameters in Normal and Abnormal Human Seminal Plasma. Australian Journal of Basic and Applied Sciences. 2008. Vol. 2, № 3. Р. 773-778.

Clinical Relevance of Oxidative Stress and Sperm Chromatin Damage in Male Infertility: An Evidence Based Analysis / M. Cocuzza, S. C. Sikka, K. S. Athayde [et al.] // International Braz. J. Urol. 2007. Vol. 33, № 5. Р. 603-621.

Oxidative stress in normospermic men undergoing infertility evaluation / F. Pasqualotto, R. Sharma, H. Kobayashi [et al.] // Journal of Andrology. 2001. Vol. 22, № 2. P. 316-322.

Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues / J. Fujii, Y. Iuchi, S. Matsuki [et al.] // Asian Journal of Andrology. 2003. Vol. 5. P. 231-242.

Sikka S. Role of Oxidative Stress and Antioxidants in Andrology and Assisted Reproductive Technology. Journal of Andrology. 2004. Vol. 25, №. 1. Р. 5-18.

Hammadeh M. E., Filippos A., Hamad F. Reactive Oxygen Species and Antioxidant in Seminal Plasma and Their Impact on Male Fertility. International Journal of Fertility and Sterility. 2009. Vol. 3, № 3. P. 87-110.

Garg V., Garg S. P. Review Paper Role of Nitric Oxide in Male Infertility. J. Indian Acad. Forensic Med. 2011. Vol. 33, № 1. Р. 65-68.

Ratnasooriya W. D., Dharmasiri M. G., Wadsworth R. M. Reduction in libido and fertility of male rats by administration of the nitric oxide (NO) synthase inhibitor N-nitro-L-arginine methyl ester. International Journal of Andrology. 2000. Vol. 23, Issue 3. P. 187-192.

Amiri I., Sheike N., Najafi R. Nitric oxide level in seminal plasma of fertile and infertile males and its correlation with sperm parameters. DARU Journal of Pharmaceutical Sciences. 2006. Vol. 14, № 4. Р. 197-202.

Effect of psychological stress on the L-arginine-nitric oxide pathway and semen quality / S. Eskiocak, A. S. Gozen, A. Taskiran [et al.] // Brazilian journal of medical and biological research. 2006. Vol. 39. P. 581-588.

Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats / G. E. Olson, V. P. Winfrey, K. E. Hill [et al.] // Reproduction. 2004. Vol. 127. P. 335–342.

Combs G. F. Jr., Combs S. B. The Role of Selenium in Nutrition. San Diego: Academic Press; 1986.

Selenium and reproduction / M. Maiorino, L. Flohe, A. Roveri [et al.] // BioFactors. 1999. № 10. Р. 251-256.

Selenium status of idiopathic infertile Nigerian males / O. Akinloye, A. O. Arowojolu, O. B. Shittu [et al.] // Biological Trace Element Research. 2005. Vol. 104, № 1. P. 9-18.

Hawkes W. C., Turek P. J. Effects of dietary selenium on sperm motility in healthy men (Article) // Journal of Andrology. - 2001. - Vol. 22, Issue 5. - P. 764-772.

Selenium and fertility in men / H. Krsnjavi, B. A. Grgurevic, D. Beker [et al.] // Trace Elements Med. 1992. № 9. Р. 107-108.

Saxena R., Jaiswal G. Selenium and Its Role in Health and Disease // Kuwait Medical Journal. 2007. Vol. 39. P. 10-18.

Avcin A. P. The insufficiency of essential trace elements and its manifestation in pathology. Archive of Pathology. 1990. № 3. P. 3-8.

Ukrainian dietary bakery product with selenium-enriched yeast / O. Stabnikova, V. Ivanov, I. Larionova [et al.] // LWT - Food Science and Technology. 2008. Vol. 41 (5). P. 890-895.

The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility / I. M. W. Ebisch, C. M. G. Thomas, W. H. M. Peters [et al.] // Human Reproduction Update. 2007. Vol. 13, № 2. Р. 163-174.

Hidiroglou M., Knipfel J. E. Zinc in mammalian sperm: A review. Journal of Dairy Science. 1984. Vol. 67. P. 1147-1156.

The experience of using L-carnitine in the treatment of secretory infertility in men (literature review) / I. V. Vinogradov, A. V. Blokhin, L. M. Afanas’eva [et al.] // Andrology and genital surgery. 2009. № 2. P. 19-22.

Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial / G. Balercia, E. Buldreghini, A. Vignini [et al.] // Fertility and Sterility. 2009. Vol. 91, № 5. Р. 1785-1792.

Agarwal A., Prabakaran S. A. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Indian Journal of Experimental Biology. 2005. Vol. 43. P. 963-974.

Folate Deficiency and Supplementation Result in DNA Methylation Defects in Sperm / M. Landry, D. Chan, J. Martel [et al.] // Biology of Reproduction. 2010. Vol. 83. P. 308.

Antioxidant intake is associated with semen quality in healthy men / B. Eskenazi, S. A. Kidd, A. R. Marks [et al.] // Hum. Reprod. 2005. Vol. 20, № 4. Р. 1006-1012.

Alpha-Tocopherol in human spermatozoa and seminal plasma: relationships with motility, antioxidant enzymes and leukocytes / P. Therond, J. Auger, A. Legrand [et al.] // Mol. Hum. Reprod. 1996. Vol. 2. P. 739-744.

World Health Organization reference values for human semen characteristics / T. G. Cooper, E. Noonan, S. von Ecardstein [et al.] // Human Reprod. Update. 2010. Vol. 16, № 3. Р. 231-245.

Cocuzza M., Agarwal A. Nonsurgical treatment of male infertility: specific and empiric therapy. Biologics: Targets & Therapy. 2007. Vol. 1, № 3. Р. 259-269.

Leifke E., Nieschlag E. Male infertility treatment in the light of evidence-based medicine. Andrologia. 1996. Vol. 28 (1). P. 23-30.

Nieschlag Е., Kamischke А. Empirical Therapies for Idiopathic Male Infertility. Andrology. 2010. Vol. 146, № 4. Р. 457-467.

Ghanem H., Shamloul R. An Evidence-Based Perspective to the Medical Treatment of Male Infertility: A Short Review. Urol. Int. 2009. Vol. 82. P. 125-129.

Antibiotics and Micronutritional Blend to Enhance Fertility Potential in Male Having Abnormal Semen Parameters / M. R. Begum, D. Miller, M. A. Salam [et al.] // The Open Clinical Trials Journal. 2009. Vol. 1. P. 7-12.

EAU Guidelines on Male Infertility / G. R. Dohle, G. M. Colpi, T. B. Hargreave [et al.] // European Urology. 2005. Vol. 48 (1). P. 703-711.

Sinclair S. Male Infertility: Nutritional and Environmental Considerations. Altern. Med. Rev. 2000. Vol. 5, № 1. Р. 28-38.

Management of Male Infertility by Neutraceutical: A Review / S. C. Shivhare, A. O. Patidar, K. G. Malviya [et al]. // Reserch journal of pharmacology and pharmacodynamics. 2011. Vol. 3, Issue 1. P. 10-14.

Myroshnikov V. M. Medicinal plants and herbal preparations in urology: tutorial. М.: Medpress-inform, 2005. 240 p.

Bulaev V. M., Shyh E. V., Sychev D. A. Modern herbal medicine. М.: Medpress-inform, 2011. 144 p.

AL-Dujaily S. S., AL-Janabi A. S., Nori M. Effect of Glycyrrhiza extract on in vitro sperm activation of asthenospermic patients. Journal of Babylon University. 2006. Vol. 11, № 3. Р. 477-483.

Demchenko A. N. Clinical diagnostic and therapy of men’s prepubertat hypogipogonadism: metod. Recommendation. Kharkiv, 2000. 16 p.

Amadi C. N., Siminialayi I. M., Orisakwe O. E. Male infertility and herbal supplementation: an update. Pharmacologia. 2011. Vol. 2, № 11. P. 323-348.



  • There are currently no refbacks.

Copyright (c) 2018 © The Author(s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski