Pathophysiological analysis of systemic and renal disregulation of pathological processes in the damage of proximal tubule in the nephrolithiasis

Yurii Rohovyi, Ariychuk Oleksandr

Abstract


The pathogenesis of urolithiasis in the modern view lies disregulating the pathological process of primary surplus mobilization reactions of protection, which leads to their further transformation in the reaction of damage that is the underlying basis for the formation of vicious circles. 299 patients with nephrolithiasis were examined, 10 patients were in the control group. Found that systemic and renal dysregulation pathological processes of stone the size of stones of 0.6 – 1.0 cm, top, middle cup the upper third of the ureter led to the formation of large and small “vicious circles”. Renal and extrarenal dysregulation pathological processes contributed to the increase in damage to the proximal tubule, since the primary damage to the said nephron. Department is not able to mobilize protective adaptive reactions aimed at increasing the excretion of acids and protein reabsorption, since they require additional energy costs. The use of the drug blemaren in nephrolithiasis reveals protective properties to reduce the manifestations of systemic and renal dysregulation pathological processes and promotes the rupture of formed large and small “vicious circles" with a decrease in proteinuria, the level of tumor necrosis factor-α, improving the transport of sodium ions, fibrinolytic activity of urine and it is advisable to develop guidelines for further use in the clinic of the drug blemaren as a promising method of treatment of urolithiasis.

Keywords


nephrolithiasis, systemic and renal dysregulation processes, large and small vicious circles, proximal tubular injury, blemaren

Full Text:

PDF

References


Gozhenko AI. Teoria bolezni [Disease theory]. Оdessa:Fenics, 2018: 236 с. (in Ukrainian).

Rohovyi Yu.Ye., Bоchаrоv А.V., Cоbilianska R.М. Rol аltеrnаtivnich mеtоdіv nаvchаnia pri vikladanii tеоrеtichnich tа clinichnix mеdichnich discipline [The role of alternative learning methods in teaching theoretical and clinical medical disciplines]. Medical education. 2003.№ 1.P.22-24. (in Ukrainian).

Boychuk ТN., Rohovyi YuYe., Ariychuk ОІ. Patofiziologia nirok za nefrolitiazu [Pathophysiology of the kidney in nephrolithiasis]. Chernivtsi: Bukovina print, 2018. 195 p. (in Ukrainian)

Pishak VP, Gozhenko AI, Rohovyi YuYe. Tubulo-itersticiyniy sindrom [Tubulo-interstitial syndrome]. Chernivtsi: Medical Academy, 2002: 221. (in Ukrainian).

Boychuk TM, Rohovyi YuYe, Popovich GB. Pathophysiologia gepatorenalnogo syndroma pri gemichniy hypoksii [Pathophysiology of the hepatorenal syndrome in hemic hypoxia]. Chernivtsi: Medical University, 2012: 192. (in Ukrainian).

Nechitaylo МYu., Bilookyi VV, Rohovyi YuYe. Jovchniy peritonit: patofiziologia i likuvania [Biliary peritonitis: pathophysiology and treatment]. Chernivtsi: BSMU, 2011.296 p. (in Ukrainian).

Rohovyi YuYe., Slobodian KV, Filipova LO. Patophysiologia vikovich osoblivostey funkcii nirok za umov nadlishku i deficitu ioniv natriu pri sulemoviy nephropatii [Pathophysiology of age characteristics of kidney function in conditions of excess and deficiency of sodium ions when Sublimate nephropathy]. Chernivtsi: Medical University, 2013: 200. (in Ukrainian).

Rohovyi YuYe., Ariychuk OI., Gerush OV. Patofiziologicheskiy analiz roli peregruzki nefrona belkom v povrejdenii proxsimalnogo kanalca pri nefroliyiaze s razmerom kamney 0.6-1.0 sm [Pathophyisiology analysis overload nephron protein in the proximal tubule damage in the nephrolithiasis size stones of 0.6-1.0 sm]. Journal of Education, Health and Sport. 2017; 7 (7):1325-1335. eISSN 2391-8306. doihttp://dx.doi.org/10.5281/zenodo.1250508 http://ojs.ukw.edu.pl/index.php/johs/article/view/5515 https://pbn.nauka.gov.pl/sedno-webapp/works/865738 (in Ukrainian)

Rohovyi YuYe., Ariychuk OI. Pathophysiologichniy analys functii nirok za cystatinom C pri utvoreni nirkovich konkrementiv 0.6-1.0 cm pri likuvani apparatom litotriptor Duet Magna [Pahophysiological analysis of the renal function by cystatin C in the formation of renal stones 0.6-1.0 cm in size in conditions of treatment with apparatus litotriptor Duet Magna] J. of Education, Health and Sport.,2017;6:545-553. doi: http://dx.doi.org/10.5281/zenodo.822488 http://ojs.ukw.edu.pl/index.php/johs/article/view/4584 (in Ukrainian).

Gozhenko AI, Rohovyi YuYe, Fedoruk OS. et [al] “Prichovane” ushkodzenia proksimalnogo viddilu nephrona [The “hidden” damage of the proximal nephron]. Odessa med.j., 2001;5: 16-19. (in Ukrainian).

Rohovyi YuYe., Zlotar OV, Filipova LO. Patophysiologia hepatorenalnogo sindromu na poliurichniy stadii sulemoviy nephropatii [Pathophysiology of hepatorenal syndrome on polunychne stage sublimate nephropathy] Chernivtsi: Medical University, 2012: 197. (in Ukrainian).

Pishak VP, Gozhenko AI, Rohovyi YuYe. et [al] Rol katepsinu D kirkovoi rechovini nirok v prignicheni proksimalnoi reabsorbtii ioniv natriu za umov massivnoi proteinurii [The role of cathepsin D cortical substance of kidneys in the inhibition of proximal reabsorption of sodium ions under conditions of massive proteinuria]. Ukrainian medical almanac, 2000; 1: 135-138. (in Ukrainian).




DOI: http://dx.doi.org/10.5281/zenodo.3460960

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)