Tobacco smoking as risk factor of laryngeal cancer

Michał Konopelko, Olga Padała, Adrianna Krupa, Maciej Putowski, Ewa Piasek


Introduction: Laryngeal cancer is one of the most common type of head and neck cancers.
It develops due to spontaneous mutation or influence of external factors (physical, biological and chemical). Cigarette smoking is primary chemical risk factor of laryngeal cancers.
Purpose: The aim of the review was to present a role of tobacco smoking in the causation
of laryngeal cancer.
State of knowledge: Many of studies performed past years confirmed the correlation between tobacco addiction and head and neck cancers. 75% of all head and neck cancers are caused
by cigarette smoking, which contains thousands of chemicals. More than 60 of them are known
as carcinogens.
Summary: Laryngeal cancer is the most common head and neck cancer. The prevalence
of laryngeal cancer is increased by several carcinogens including tobacco smoking, which
is known as the major risk factor of this type of cancers.


tobacco; laryngeal cancer; larynx; squamous cell carcinoma

Full Text:



Kawecki A, Nawrocki S, Golusiński W, Grzesiakowska U, Jassem J, et al. Nowotwory nabłonkowe narządów głowy i szyi. Zalecenia postępowania diagnostyczno-terapeutycznego w nowotworach złośliwych–2013 r.

Steuer CE, El‐Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017, 67(1), 31-50.

Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol. 2006 24(22), 3693-3704.

Karatzanis AD, Psychogios G, Waldfahrer F, Kapsreiter M, Zenk J, et al. Management of locally advanced laryngeal cancer. J Otolaryngol Head Neck Surg. 2014, 43(1), 4.

Jurkiewicz D, Dżaman K, Rapiejko P. Czynniki ryzyka raka krtani. Pol. Merk. Lek. 2006 121, 94.

Janczewski G, et al. Otolaryngologia praktyczna. 2007, 507-517

Talamini R, Bosetti C, La Vecchia C, Dal Maso L, Levi F, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case–control study. Cancer Causes Control. 2002 13(10), 957-964.

Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, et al. Tobacco and cancer: recent epidemiological evidence. J Nati Cancer Inst. 2004, 96(2), 99-106.

Melinceanu L, Sarafoleanu C, Lerescu L. Impact of smoking on the immunological profile of patients with laryngeal carcinoma. J Med life. 2009, 2(2), 211.

Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol. 2001, 14(7), 767-790.

Hecht SS. Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg. 2016, 391(6), 603-613.

Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N., Hecht SS, et al. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene. 2002, 21(48), 7435.



  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski