Adiponectin as novel key player in tumors of adrenal glands – what do we know? A review
Abstract
Aim of the study: This article summarizes the current knowledge about adiponectin and its receptors in the tumorigenesis of adrenal neoplasia as well as their role in the developing obesity-related diseases.
Description of knowledge: Adiponectin, an adipose tissue-derived pleiotropic hormone, with anti-inflammatory, anti-atherogenic, anti-diabetic, and insulin-sensitizing properties is engaged in developing diabetes mellitus type 2, hypertension or ischemic heart disease, but the latest researches also revealed its role in tumor cells proliferation and angiogenesis. The possible effects of adiponectin and its two receptors in both physiological processes and pathophysiology of adrenal glands is not fully understood. Recent studies suggested that adiponectin receptors expression is significantly higher in hormonally active adrenal tumors as compared to normal tissues of adrenal glands, which may prove the involving of adipose tissue and periadrenal fat depot in regulating the function of adrenal cortex or medulla.
Conclusions: Adiponectin may be predictive factor of developing metabolic disorders in the group of patients with accidentally detected adrenal lesions. The discovering of its exact mechanism may result in modifying novel screening options as well as diagnostic process and treatment scheme. Therefore, further research is required to determine the effect of adiponectin and its role in the pathogenesis of obesity-related diseases in the course of adrenal tumors.
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Bednarczuk T, Bolanowski M, Sworczak K, Górnicka B, Cieszanowski A, Otto M, et al. Adrenal incidentaloma in adults - management recommendations by the Polish Society of Endocrinology. Endokrynol Pol. 2016;67(2):234-258. doi: 10.5603/EP.a2016.0039.
Bhat HS, Tiyadath BN. Management of Adrenal Masses. Indian J Surg Oncol. 2017;8(1):67-73. doi: 10.1007/s13193-016-0597-y.
Bittner JG, Brunt LM. Evaluation and management of adrenal incidentaloma. J Surg Oncol. 2012;106(5):557-564. doi: 10.1002/jso.23161.
Cichocki A, Samsel R, Papierska L, Roszkowska-Purska K, Nowak K, Jodkiewicz Z, et al. Adrenal tumour bigger than 5 cm - what could it be? An analysis of 139 cases. Endokrynol Pol. 2017;68(4):411-415. doi: 10.5603/EP.a2017.0039.
Androulakis II, Kaltsas G, Piaditis G, Grossman AB. The clinical significance of adrenal incidentalomas. Eur J Clin Invest. 2011;41(5):552-560. doi: 10.1111/j.1365-2362.2010.02436.x.
Griffing GT. A-I-D-S: the new endocrine epidemic. J Clin Endocrinol Metab. 1994;79(6):1530-1531.
Babińska A, Siekierska-Hellmann M, Błaut K, Lewczuk A, Wiśniewski P, Gnacińska M, et al. Hormonal activity in clinically silent adrenal incidentalomas. Arch Med Sci. 2012;8(1):97-103. doi: 10.5114/aoms.2012.27288.
Mannelli M, Lenders JW, Pacak K, Parenti G, Eisenhofer G. Subclinical phaeochromocytoma. Best Pract Res Clin Endocrinol Metab. 2012;26(4):507-515. doi: 10.1016/j.beem.2011.10.008.
Libè R, Dall'Asta C, Barbetta L, Baccarelli A, Beck-Peccoz P, Ambrosi B. Long-term follow-up study of patients with adrenal incidentalomas. Eur J Endocrinol. 2002;147(4):489-494.
Elenkova A, Matrozova J, Zacharieva S, Kirilov G, Kalinov K. Adiponectin - A possible factor in the pathogenesis of carbohydrate metabolism disturbances in patients with pheochromocytoma. Cytokine. 2010;50(3):306-310. doi: 10.1016/j.cyto.2010.03.011.
Emral R, Aydoğan Bİ, Köse AD, Demir Ö, Çorapçıoğlu D. Could a nonfunctional adrenal incidentaloma be a risk factor for increased carotid intima-media thickness and metabolic syndrome. Endocrinol Diabetes Nutr. 2019; pii: S2530-0164(19)30037-0. doi: 10.1016/j.endinu.2019.01.007.
Tuna MM, Imga NN, Doğan BA, Yılmaz FM, Topçuoğlu C, Akbaba G, et al. Non-functioning adrenal incidentalomas are associated with higher hypertension prevalence and higher risk of atherosclerosis. J Endocrinol Invest. 2014;37(8):765-768. doi: 10.1007/s40618-014-0106-5.
Dogruk Unal A, Ayturk S, Aldemir D, Bascil Tutuncu N. Serum Adiponectin Level as a Predictor of Subclinical Cushing's Syndrome in Patients with Adrenal Incidentaloma. Int J Endocrinol. 2016;2016:8519362. doi: 10.1155/2016/8519362.
Babinska A, Kaszubowski M, Sworczak K. Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI). Endocr J. 2018;65(8):849-858. doi: 10.1507/endocrj.EJ18-0066.
Taya M, Paroder V, Bellin E, Haramati LB. The relationship between adrenal incidentalomas and mortality risk. Eur Radiol. 2019. doi: 10.1007/s00330-019-06202-y.
Di Dalmazi G, Vicennati V, Garelli S, Casadio E, Rinaldi E, Giampalma E, et al. Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome: a 15-year retrospective study. Lancet Diabetes Endocrinol. 2014;2(5):396-405. doi: 10.1016/S2213-8587(13)70211-0.
Prins JB. Adipose tissue as an endocrine organ. Best Pract Res Clin Endocrinol Metab. 2002;16(4):639-651.
Smitka K, Marešová D. Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment. Prague Med Rep. 2015;116(2):87-111. doi: 10.14712/23362936.2015.49.
Kargi AY, Iacobellis G. Adipose tissue and adrenal glands: novel pathophysiological mechanisms and clinical applications. Int J Endocrinol. 2014;2014:614074. doi: 10.1155/2014/614074.
Ramanjaneya M, Conner AC, Brown JE, Chen J, Digby JE, Barber TM, et al. Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways. Biochim Biophys Acta. 2011;1813(5):802-809. doi: 10.1016/j.bbamcr.2011.02.010.
Rossi GP, Sticchi D, Giuliani L, Bernante P, Zavattiero S, Pessina AC, et al. Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas. Int J Mol Med. 2006;17(6):975-980.
Li P, Sun F, Cao HM, Ma QY, Pan CM, Ma JH, et al. Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: adiponectin regulates steroidogenesis. Biochem Biophys Res Commun. 2009;390(4):1208-1213. doi: 10.1016/j.bbrc.2009.10.122.
Paschke L, Zemleduch T, Rucinski M, Ziolkowska A, Szyszka M, Malendowicz LK. Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis. Peptides. 2010;31(9):1715-1724. doi: 10.1016/j.peptides.2010.06.007.
Chou SH, Tseleni-Balafouta S, Moon HS, Chamberland JP, Liu X, Kavantzas N, et al. Adiponectin receptor expression in human malignant tissues. Horm Cancer. 2010;1(3):136-145. doi: 10.1007/s12672-010-0017-7.
Babińska A, Pȩksa R, Światkowska-Stodulska R, Wiśniewski P, Sworczak K. Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion. Cancer Biomark. 2018;22(2):325-332. doi: 10.3233/CBM-171049.
Babińska A, Pęksa R, Wiśniewski P, Świątkowska-Stodulska R, Sworczak K. Diagnostic and prognostic role of SF1, IGF2, Ki67, p53, adiponectin, and leptin receptors in human adrenal cortical tumors. J Surg Oncol. 2017;116(3):427-433. doi: 10.1002/jso.24665.
Isobe K, Fu L, Tatsuno I, Takahashi H, Nissato S, Hara H, et al. Adiponectin and adiponectin receptors in human pheochromocytoma. J Atheroscler Thromb. 2009;16(4):442-447.
Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A. 2003;100(24):14211-14216.
Ehrhart-Bornstein M, Arakelyan K, Krug AW, Scherbaum WA, Bornstein SR. Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res. 2004;30(4):865-870.
Ermetici F, Malavazos AE, Corbetta S, Morricone L, Dall'Asta C, Corsi MM, et al. Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma. Metabolism. 2007;56(5):686-692. doi: 10.1016/j.metabol.2006.12.018.
Letizia C, Petramala L, Di Gioia CR, Chiappetta C, Zinnamosca L, Marinelli C, et al. Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia. J Clin Endocrinol Metab. 2015;100(1):E101-104. doi: 10.1210/jc.2014-2274.
Lazúrová I, Spišáková D, Wagnerová H, Habalová V, Dravecká I, Darina P, et al. Clinically silent adrenal adenomas - their relation to the metabolic syndrome and to GNB3 C825T gene polymorphism. Wien Klin Wochenschr. 2011;123(19-20):618-622. doi: 10.1007/s00508-011-0064-2.
Reincke M, Beuschlein F, Slawik M, Borm K. Molecular adrenocortical tumourigenesis. Eur J Clin Invest. 2000;30 Suppl 3:63-68.
Akkus G, Evran M, Sert M, Tetiker T. Adipocytokines in Non-functional Adrenal Incidentalomas and Relation with Insulin Resistance Parameters. Endocr Metab Immune Disord Drug Targets. 2019;19(3):326-332. doi: 10.2174/1871530318666181009112042.
Ashizawa N, Takagi M, Seto S, Suzuki S, Yano K. Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomy. Intern Med. 2007;46(7):383-385.
Makimura H, Mizuno TM, Bergen H, Mobbs CV. Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA. Am J Physiol Endocrinol Metab. 2002;283(6):E1266-1271. doi: 10.1152/ajpendo.00227.2002.
Okauchi Y, Ishibashi C, Shu K, Adachi S, Mineo I. Decreased Serum Adiponectin Level during Catecholamine Crisis in an Obese Patient with Pheochromocytoma. Intern Med. 2018;57(9):1253-1257. doi: 10.2169/internalmedicine.9089-17.
Bosanska L, Petrak O, Zelinka T, Mraz M, Widimsky J Jr, Haluzik M. The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue. Physiol Res. 2009;58(3):319-325.
Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, et al. Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice. J Am Coll Cardiol. 2017;69(14):1811-1820. doi: 10.1016/j.jacc.2017.01.052.
Dick SM, Queiroz M, Bernardi BL, Dall'Agnol A, Brondani LA, Silveiro SP. Update in diagnosis and management of primary aldosteronism. Clin Chem Lab Med. 2018;56(3):360-372. doi: 10.1515/cclm-2017-0217.
Urbanet R, Pilon C, Calcagno A, Peschechera A, Hubert EL, Giacchetti G, et al. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. J Clin Endocrinol Metab. 2010;95(8):4037-4042. doi: 10.1210/jc.2010-0097.
Rojas E, Rodríguez-Molina D, Bolli P, Israili ZH, Faría J, Fidilio E, et al. The role of adiponectin in endothelial dysfunction and hypertension. Curr Hypertens Rep. 2014;16(8):463. doi: 10.1007/s11906-014-0463-7.
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