Sodium-glucose co-transporter 2 inhibitors – a review article

Marcin Makuch, Marcelina Makuch, Ewa Krzewicka-Romaniuk, Grzegorz Dzida

Abstract


Antihyperglycemic interventions have centered on increasing insulin availability, improving insulin sensitivity or restoring β-cell activity to normalize plasma glucose levels in patients with type 2 diabetes mellitus. An alternative strategy is to enhance urinary glucose excretion by targeting renal sodium-glucose co-transporters (SGLTs). Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce blood glucose by increasing urinary glucose excretion and present a valuable therapeutic option for the treatment of type 2 diabetes. Presently, clinically available SGLT2 inhibitors include canagliflozin, dapagliflozin and empagliflozin.

Keywords


sodium-glucose co-transporter 2 inhibitors; glucose; type 2 diabetes; cardiovascular effects

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References


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DOI: http://dx.doi.org/10.5281/zenodo.3372353

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