The case series of baclofen intoxication

Michał Kos, Justyna Drankowska, Andrzej Kościuk, Karolina Widłak, Michał Tchórz


Baclofen, a gamma-amino butyric acid type B (GABAb) inhibitor, is commonly used in management of spasticity and other medical conditions, such as alcohol dependency. However, given its mechanism of action, increasing usage of baclofen raises concerns about possibility of intoxication. The authors present herein three cases of baclofen intoxication of patients in various age and general condition.


baclofen; intoxication

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Woolf SM, Baum CR. Baclofen Pumps. Pediatric Emergency Care 2017; 33(4):271–275. doi:10.1097/PEC.0000000000001090.

Yoon YK, Lee KC, Cho HE, Chae M, Chang J-W, Chang W-S, et al. Outcomes of intrathecal baclofen therapy in patients with cerebral palsy and acquired brain injury. Medicine 2017; 96(34):e7472. doi:10.1097/MD.0000000000007472.

Franchitto N, Rolland B, Pelissier F, Simon N. How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates.

Frontiers in psychiatry 2018; 9:417. doi:10.3389/fpsyt.2018.00417.

Ertzgaard P, Campo C, Calabrese A. Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen. Journal of Rehabilitation Medicine 2017; 49(3):193–203. doi:10.2340/16501977-2211.

Beraha EM, Salemink E, Goudriaan AE, Bakker A, de Jong D, Smits N, et al. Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial. European Neuropsychopharmacology 2016; 26(12):1950–1959. doi:10.1016/j.euroneuro.2016.10.006.

Liu J, Wang L-N. Baclofen for alcohol withdrawal. The Cochrane database of systematic reviews 2017; 8(8):CD008502. doi:10.1002/14651858.CD008502.pub5.

Reynaud M, Aubin H-J, Trinquet F, Zakine B, Dano C, Dematteis M, et al. A Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients—The ALPADIR Study. Alcohol and Alcoholism 2017; 52(4):439–446. doi:10.1093/alcalc/agx030.

Pelissier F, de Haro L, Cardona F, Picot C, Puskarczyk E, Sapori JM, al. Self-poisoning with baclofen in alcohol-dependent patients: national reports to French Poison Control Centers, 2008–2013. Clinical Toxicology 2017; 55(4):275–284. doi:10.1080/15563650.2017.1284330.

Holla B, Gowda GS, Prabhu L, Baby S, Viswanath B, Chand P, et al. High doses of Baclofen as suicide attempt in patients with alcohol use disorders – A serious concern. Asian Journal of Psychiatry 2015; 17:99–100. doi:10.1016/j.ajp.2015.06.015.

Masi G, Mucci M, Liboni F, Ferrari A, Sicca F. Self-Induced Multiple Comas With Recreational Baclofen Overdoses in an Adolescent Girl. Journal of Clinical Psychopharmacology 2013; 33(6):830–832. doi:10.1097/JCP.0b013e31829b61ba.

Weißhaar GF, Hoemberg M, Bender K, Bangen U, Herkenrath P, Eifinger F, al. Baclofen intoxication: a “fun drug” causing deep coma and nonconvulsive status epilepticus—a case report and review of the literature. European Journal of Pediatrics 2012; 171(10):1541–1547. doi:10.1007/s00431-012-1780-y.

Alvis BD, Sobey CM. Oral Baclofen Withdrawal Resulting in Progressive Weakness and Sedation Requiring Intensive Care Admission. The Neurohospitalist 2017; 7(1):39–40. doi:10.1177/1941874416637404.

Ross JC, Cook AM, Stewart GL, Fahy BG. Acute Intrathecal Baclofen Withdrawal: A Brief Review of Treatment Options. Neurocritical Care 2011; 14(1):103–108. doi:10.1007/s12028-010-9422-6.



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Journal of Education, Health and Sport formerly Journal of Health Sciences

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1223 Journal of Education, Health and Sport eISSN 2391-8306 7

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