Proton pump inhibitors overuse - consequences among patients

Patrycja Kmiotek, Andrzej Materniak, Barbara Skrzydło-Radomańska

Abstract


Introduction
Omeprazole was first proton pump inhibitor (PPI) approved for use by patients. Thirty years have passed since then. Due to their effectiveness, low price and safety proton pump inhibitors have become one of the most frequently prescribed medicines in the world. In recent years, more attention has been paid to the problem of their overuse.
Aim of the study
The aim of our study was to investigate the scale of proton pump inhibitors overprescription and possible resulting side effects.
State of knowledge
Analyzed observational studies proves that problem is present both in hospitals and ambulatory clinics. Research shows increasingly frequent use of this medicines in case of non-specific abdominal discomfort or in many cases without any indications. This results in prolonged and unnecessary therapy. The possibility of obtaining medicines over the counter and patients non-compliance, are also a challenge in maintaining high-quality therapy. In many cases patients taking drugs irregularly or do not stop therapy, even being free from symptoms.
Conclusions
Despite the fact that proton pump inhibitors are considered safe drugs, more attention should be paid to the compatibility of their use with recommendations. There are also evidences about the possibility of side effects associated with long-term proton pump inhibitor therapy, which can be particularly dangerous for older patients with multiple diseases. It is necessary to inform patients about the need of discontinuation therapy in case of recovery, which will reduce the risk of adverse effects.

Keywords


Proton Pump Inhibitors; PPI; Proton pump

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References


Forte JG, Lee HC. Gastric adenosine triphosphatases: a review of their possible role in HCl secretion. Gastroenterology, 1977 Oct;73(4 Pt 2):921-6.

Olbe L, Carlsson E, Lindberg P. A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nature Reviews Drug Discovery, February 2003 2, 132–139.

Szymczyk H. Safety of proton pump inhibitor therapy. Lek w Polsce, Vol 25 Nr 9’15 (292).

Strand DS, Kim D, Peura DA. 25 Years of proton pump inhibitors: a comprehensive review. Gut and Liver, Vol. 11, No. 1, January 2017, pp. 27-37.

Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Current Gastroenterology Reports, 2008 December, 10(6): 528–534.

Bashford JN, Norwood J, Chapman SR. Why are patients prescribed proton pump inhibitors? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database. BMJ, 1998 Aug 15;317(7156):452-6.

Heidelbaugh JJ, Goldberg KL, Inadomi JM. Magnitude and economic effect of overuse of antisecretory therapy in the ambulatory care setting. The American Journal of Managed Care, 2010 Sep;16(9):e228-34.

Ahrens D, Behrens G, Himmel W, Kochen MM, Chenot JF. Appropriateness of proton pump inhibitor recommendations at hospital discharge and continuation in primary care. International Journal of Clinical Practice, 2012 Aug;66(8):767-773.

Eid SM, Boueiz A, Paranji S, Mativo C, Landis R, Abougergi MS. Patterns and predictors of proton pump inhibitor overuse among academic and non-academic hospitalists. Internal Medicine, 2010;49(23):2561-8.

Heidelbaugh JJ, Inadomi JM. Magnitude and economic impact of inappropriate use of stress ulcer prophylaxis in non-ICU hospitalized patients. American Journal of Gastroenterology, 2006 Oct;101(10):2200-5.

Gawron AJ, Rothe J, Fought AJ, Fareeduddin A, Toto E, Boris L, Kahrilas PJ, Pandolfino JE. Many patients continue using proton pump inhibitors after negative results from tests for reflux disease. Clinical Gastroenterology And Hepatology, 2012 Jun;10(6):620-5.

Sheikh I, Waghray A, Waghray N, Dong C, Wolfe MM. Consumer use of over-the-counter proton pump inhibitors in patients with gastroesophageal reflux disease. The American Journal of Gastroenterology, 2014 Jun;109(6):789-94.

Haastrup P, Paulsen MS, Begtrup LM, Hansen JM, Jarbøl DE. Strategies for discontinuation of proton pump inhibitors: a systematic review. Family Practice, 2014 Dec;31(6):625-30.

Seto CT, Jeraldo P, Orenstein R, Chia N, DiBaise JK. Prolonged use of a proton pump inhibitor reduces microbial diversity: implications for Clostridium difficile susceptibility. Microbiome 2014 Nov 25;2:42.

Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. The American Journal of Gastroenterology, 2012 Jul;107(7):1011-9.

FDA Drug Safety Communication: Clostridium difficile-associated diarrhea can be associated with stomach acid drugs known as proton pump inhibitors (PPIs). United States, 2012.

Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am. J. Gastroenterol. 2007 Sep;102(9):2047-56.

Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid suppressive drugs. JAMA 2004 Oct 27;292(16):1955-60.

Toh BH, van Driel IR, Gleeson PA. Pernicious Anemia. N Engl J Med, 1997 Nov 13;337(20):1441-8.

Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA, 2013 Dec, 11;310(22):2435-42.

Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, Grams ME. Proton pump Inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 2016 Feb, 176(2):238-46.

Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, König HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M. Risk of dementia in elderly patients with the use of proton pump inhibitors. Eur Arch Psychiatry Clin Neurosci. 2015 Aug;265(5):419-28.

Jaynes M, Kumar AB. The risks of long-term use of proton pump inhibitors: a critical review. Therapeutic Advances in Drug Safety, 2018 Nov 19;10:2042098618809927.




DOI: http://dx.doi.org/10.5281/zenodo.3407285

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