Patophysiology of metabolic syndrome in mentally ill patients treated by antipsychotics

Ewa Krzewicka-Romaniuk, Dagna Siedlecka, Marcelina Makuch, Artur Romaniuk


The metabolic syndrome is increasingly named as epidemic of our time. It affects about 20-25% of the world's population and is associated with a twofold increase in the risk of death and a threefold increase in the risk of heart attack and stroke. Numerous scientific studies confirm the more frequent occurrence of the metabolic syndrome among the mentally ill patients than in the general population.
It is related not only to common inflammatory etiology of psychiatric disorders and metabolic syndrome, endocrinopathies accompanying mental illness, unhealthy lifestyle of psychiatric patients or genetic predispositions of this group of patients to the development of metabolic disorders, but also with the use of psychiatric drugs such as antipsychotics or mood stabilizers.


metabolic syndrome; antipsychotics; obesity; SGAs

Full Text:



Kelli HM, Kassas I. Cardio Metabolic Syndrome: A Global Epidemic. J Diabetes Metab [Internet]. 2016 [cytowane 24 lipiec 2019];6(3). Dostępne na:

Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep [Internet]. 2018 [cytowane 24 lipiec 2019];20(2). Dostępne na:

Ho CSH, Zhang MWB, Mak A, Ho RCM. Metabolic syndrome in psychiatry: advances in understanding and management. Advances in Psychiatric Treatment. marzec 2014;20(2):101–12.

Stephen M. Stahl. Podstawy psychofarmakologii Teoria i praktyka. trzecie. T. 2. Gdańsk: Via Medica; 2009.

Rzewuska s457_Psychiatria Polska 4_2007.pdf [Internet]. [cytowane 24 lipiec 2019]. Dostępne na:

Laimer M, Ebenbichler CF, Kranebitter M, Eder U, Mangweth B, Weiss E, i in. Olanzapine-induced hyperglycemia: role of humoral insulin resistance-inducing factors. J Clin Psychopharmacol. kwiecień 2005;25(2):183–5.

Henderson DC. Atypical antipsychotic-induced diabetes mellitus: how strong is the evidence? CNS Drugs. 2002;16(2):77–89.

Lund BC, Perry PJ, Brooks JM, Arndt S. Clozapine use in patients with schizophrenia and the risk of diabetes, hyperlipidemia, and hypertension: a claims-based approach. Arch Gen Psychiatry. grudzień 2001;58(12):1172–6.

McQuade RD, Stock E, Marcus R, Jody D, Gharbia NA, Vanveggel S, i in. A comparison of weight change during treatment with olanzapine or aripiprazole: results from a randomized, double-blind study. J Clin Psychiatry. 2004;65 Suppl 18:47–56.

Heiskanen T, Niskanen L, Lyytikäinen R, Saarinen PI, Hintikka J. Metabolic syndrome in patients with schizophrenia. J Clin Psychiatry. maj 2003;64(5):575–9.



  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski