The role of resveratrol in cellular aging

Daria Bieniek, Natalia Skierkowska, Monika Prylińska, Jakub Husejko, Małgorzata Gajos, Hanna Bednarek, Filip Biernacki, Kornelia Kędziora-Kornatowska

Abstract


Resveratrol is a substance present in grapes, blueberries and peanuts. Its concentration in grapes varies depending on the type and strain of the fruit. Resveratrol has a number of health-promoting properties for the body. Researchers most often indicate antioxidant, anticancer and cardioprotective activity, especially in the context of coronary heart disease, as well as anti-inflammatory, inhibiting the proliferation of pro-inflammatory cytokines. Resveratrol plays a neuroprotective role in the body, especially in the context of Alzheimer's disease, has a positive effect on the genes responsible for longevity and is the perpetrator of the so-called "The French paradox". The aim of the work was to present the role of resveratrol in cellular aging.

Keywords


resveratrol; aging; cellular aging

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References


Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017). The therapeutic potential of resveratrol: a review of clinical trials. NPJ precision oncology, 1(1), 35.

Ko, J. H., Sethi, G., Um, J. Y., Shanmugam, M. K., Arfuso, F., Kumar, A. P., ... & Ahn, K. S. (2017). The role of resveratrol in cancer therapy. International journal of molecular sciences, 18(12), 2589.

Gocmez, S. S., Gacar, N., Utkan, T., Gacar, G., Scarpace, P. J., & Tumer, N. (2016). Protective effects of resveratrol on aging-induced cognitive impairment in rats. Neurobiology of learning and memory, 131, 131-136.

Li, Y. R., Li, S., & Lin, C. C. (2018). Effect of resveratrol and pterostilbene on aging and longevity. Biofactors, 44(1), 69-82.

Giovinazzo G., Ingrosso I., Paradiso A., De Gara L., Santino A.: Resveratrol biosynthesis: plant metabolic engineering for nutritional improvement of food. Plant Foods Hum. Nutr., 2012; 67: 191-199

Saiko P., Szakmary A., Jaeger W., Szekeres T.: Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat. Res., 2008, 1-2 (658), 68-94.

Stervbo U., Vang O., Bonnesen Ch.: A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chem., 2007, 2 (101), 449-457.

Kopeć A., Piątkowska E., Leszczyńska T., Bieżanowska-Kopeć R.: Prozdrowotne właściwości resweratrolu. ŻYWNOŚĆ. Nauka. Technologia. Jakość, 2011, 5 (78), 5 – 15

Dipak K.D., Maulik N.: Resveratrol in cardioprotection. A therapeutic promise of alternative medicine. Molecular Inventions, 2006, 1 (6), 36-47.

Gu X., Chu Q., O’Dwyer M., Zeece M.: Analysis of resveratrol in wine by capillary electrophoresis. J. Chromatogr. A, 2000, 1-2 (881), 471-481.

Abril M., Negueruela A.I., Pérez C., Juan T., Estopañán G.: Preliminary study of resveratrol content in Aragón red and rosé wines. Food Chem., 2005, 4 (92), 729-736.

Karlsson J., Emgard M., Brundin P., Burkitt M.J.: Trans-resveratrol protects embryonic mesencephalic cells from tert-butyl hydroperoxide: electron paramagnetic resonance spin trapping evidence for a radical scavenging mechanism. J. Neuroch., 2000, 1 (75), 141-150.

Pervaiz S.: Resveratrol: from grapevines to mammalian biology. FASEB J., 2003, 17, 1975-1985.

Medina-Bolivar F., Condori J., Rimando A.M., Hubstenberger J., Shelton K., O’Keefe S.F., Bennett S., Dolan M.C.: Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry, 2007, 14 (68), 1992-2003.

Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992; 339:1523-6.

Artero A., Artero A., Tarín J.J., Cano A.: The impact of moderate wine consumption on health. Maturitas, 2015; 80: 3-13

Chiva-Blanch G., Arranz S., Lamuela-Raventos R.M., Estruch R.: Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies. Alcohol Alcohol., 2013; 48: 270-277

Huang T.C., Lu K.T., Wo Y.Y., Wu Y.J., Yang Y.L.: Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation. PLoS One, 2011; 6: e29102

Janssen I., Landay A.L., Ruppert K., Powell L.H.: Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years: the study of women’s health across the nation (SWAN). Nutr. Aging, 2014; 2: 91-99

Lephart E.D., Sommerfeldt J.M., Andrus M.B.: Resveratrol: influences on gene expression in human skin. J. Functional Foods, 2014; 10: 377-384

Tang P.C., Ng Y.F., Ho S., Gyda M., Chan S.W.: Resveratrol and cardiovascular health–promising therapeutic or hopeless illusion? Pharmacol. Res., 2014; 90: 88-115

Pieszka M, Szczurek P, Ropka-Molik K, Oczkowicz M, Pieszka M: The role of resveratrol in the regulation of cell metabolism – a review. Postepy Hig Med Dosw (online), 2016; 70; 1117-1123

Mattison J.A., Wang M., Bernier M., Zhang J., Park S.S., Maudsley S., An S.S., Santhanam L., Martin B., Faulkner S., Morrell C., Baur J.A., Peshkin L., Sosnowska D., Csiszar A. i wsp.: Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab., 2014; 20: 183-190

Nwachukwu J.C., Srinivasan S., Bruno N.E., Parent A.A., Hughes T.S., Pollock J.A., Gjyshi O., Cavett V., Nowak J., Garcia-Ordonez R.D., Houtman R., Griffin P.R., Kojetin D.J., Katzenellenbogen J.A., Conkright M.D., Nettles K.W.: Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 2014; 3: e02057

Pezzuto J.M.: The phenomen of resveratrol: redefining the virtues of promiscuity. Ann. N.Y. Acad. Sci., 2011; 1215: 123-130

Toliopoulos I.K., Simos Y.V., Oikonomidis S., Karkabounas S.C.: Resveratrol diminishes platelet aggregation and increases susceptibility of K562 tumor cells to natural killer cells. Indian J. Biochem. Biophys., 2013; 50: 14-18

Yazir Y., Utkan T., Gacar N., Aricioglu F.: Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress. Physiol. Behav, 2015; 138: 297-304

Yu W., Fu Y.C., Wang W.: Cellular and molecular effects of resveratrol in health and disease. J. Cell. Biochem., 2012; 113: 752-759

Sinkiewicz, W. (2010). Czerwone wino, procyjanidy, resweratrol i długowieczność. Kardiologia po Dyplomie, 9(8).

Dudley J, Das S, Mukherjee S, Das DK. Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J Nutr Biochem 2008; 20: 443-452.

Wang Q, Xu J, Rottinghaus GE, Simonyi A et al.. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002; 27: 439-447.

Baur JA, Pearson KJ, Price NL et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 16: 337-342.

Das DK, Mukherjee S, Ray D. Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 2010 Mar 18. [ogłoszono on-line przed publikacją].

Lagouge M, Argmann C, Gerhart-Hines Z et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 15: 1109-1122.

Blüher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 24: 572-574.

Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 2005; 280: 17187-17195.

Kaeberlein M, McDonagh T, Helwerg B et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem 2005; 280: 17038-17045.

Mukherjee S, Lekli I, Gurusamy N, Bertelli AA, Das DK. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med 2009; 1: 573-578.

Sikora, E. (2014). Starzenie i długowieczność. Postępy Biochemii, 60(2), 125-37.

Naiman S, Cohen HY (2012) The contentious history of sirtuin debates. Rambam Maimonides Med J 3: e0022

Le Couteur DG, McLachlan AJ, Quinn RJ, Simpson SJ, de Cabo R (2012) Aging biology and novel targets for drug discovery. J Gerontol A Biol Sci Med Sci 67: 168-174

Kincaid B, Bossy-Wetzel E (2013) Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neuro 5: 48

Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. (2012) Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov 11: 443-4461.

Szkudelski T., Szkudelska K.: Anti-diabetic effects of resveratrol. Ann N Y Acad Sci, 2011; 1215: 34-39

Brasnyo P., Molnar G.A., Mohas M., Marko L., Laczy B., Cseh J., Mikolas E., Szijarto I.A., Merei A., Halmai R,. Meszaros L.G., Sumegi B., Wittmann I.: Resveratrol improves insulin sensitivity, reduces oxidative stress andactivates the Akt pathway in type 2 diabetic patients. Br. J. Nutr., 2011; 106: 383-389

Smoliga J. M., Baur J.A., Hausenblas H. A.: Resveratrol and health – a comprehensive review of human clinical trials. Mol Nutr. Food Res., 2011; 55(8): 1129-1141

Kucińska M., Murias M.: Sirtuiny – droga do długowieczności czy ślepy zaułek? Pol. Merk. Lek., 2010; 28(164): 158-161

Zdrojewicz Z., Belowska-Bień K.: Resweratrol – działanie i znaczenie kliniczne. Adv. Clin. Exp. Med., 2005, 5 (14), 1051-1056.

Andersen G., Burkon A., Sulzmaier F.J., Walker J.M., Leckband G., Fuhst R., Erbersdobler H.F., Somoza V.: High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression. Mol. Nutr. Food Res., 2011; 55: 1197-1206

Dal-Pan A, Blanc S. Aujard F. Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiology 2010; 10: 11doi: 10.1186/1472-6793-10-11.

Buryanovskyy L, Fu Y, Boyd M, Ma Y, Hsieh TC, Wu JM, Zhang Z (2004) Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 43: 11417-11426

Bertelli A, Falchi M, Lo SR, Morelli R (2004) EPR evaluation of the antiradical activity of wines containing high concentrations of resveratrol. Drugs Exp Clin Res 30: 111-115

Fukao H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, Oiwa K, Kawai Y, Suwa M, Yamamoto J (2004) Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Blood Coagul Fibrinolysis 15: 441-446

Svajger U, Jeras M (2012) Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases. Int Rev Immunol 31: 202-222

Han YS, Zheng WH, Bastianetto S, Chabot JG, Quirion R (2004) Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br J Pharmacol 141: 997-1005

Lofrumento DD, Nicolardi G, Cianciulli A, De NF, La P, V, Carofiglio V, Dragone T, Calvello R, Panaro MA (2014) Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s-like disease: Possible role of SOCS-1 in reducing pro-inflammatory responses. Innate Immun 20: 249-260

Jin F, Wu Q, Lu YF, Gong QH, Shi JS (2008) Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson’s disease in rats. Eur J Pharmacol 600: 78-82

Baatout S, Derradji H, Jacquet P, Ooms D, Michaux A, Mergeay M (2004) Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol. Int J Mol Med 13: 895-902

Fulda S (2010) Resveratrol and derivatives for the prevention and treatment of cancer. Drug Discov Today 15: 757-765

Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493-506

Demidenko ZN, Blagosklonny MV (2009) At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 8: 1901-1904

Piver B., Fer M., Vitrae X., Merillon J.M., Dreano Y., Berthou F., Lucas D.: Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem. Pharmacol., 2004, 4 (68), 773-782.

Mikulski D.: Teoretyczne badanie biofizyko chemicznych właściwości resweratrolu i jego pochodnych. Praca doktorska Uniwersytet im. A. Mickiewicza, Poznań 2010; 9-49.

Espı´n J, C, Garcı´a-Conesa M.T., Toma´s-Barbera´n F.A Carlos J.E., Garcı´a Conesa M.T., Francisco A.T.B.: Nutraceuticals: Facts and fiction. Phytochemistry, 2007, 22-24 (68), 2986-3008.

Crowell J.A., Korytko P.J., Morrissey R.L., Booth T.D., Levine B.S.: Resveratrol - associated renal toxicity. Toxicol. Sci., 2004, 2 (82), 614-619.

Bonnefont-Rousselot, D. Resveratrol and Cardiovascular Diseases. Nutrients, 2016, 8(5), 250.

Saleem, T.S.M., Basha, S.D. Red wine: A drink to your heart. Journal of cardiovascular disease research, 2010, 1(4), 171-176.

Rehm, J., Shield, K.D. Global alcohol-attributable deaths from cancer, liver cirrhosis, and injury in 2010. Alcohol Research: Current Reviews, 2013, 35(2), 174-183.

Spanagel, R. Alcohol addiction research: from animal models to clinics. Best Practice & Research: Clinical Gastroenterology, 2003, 17(4), 507-518.

Burns, J., Yokota, T., Ashihara, H., Lean, M.E.J., Crozier, A. Plant Foods and Herbal Sources of Resveratrol. Journal of Agricultural and Food Chemistry, 2002, 50(11), 3337-3340.

Neves, A.R., Lucio, M., Lima, J.L., Reis, S. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions. Current Medicinal Chemistry, 2012, 19(11), 1663-1681.




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