Ketogenic diet in pediatric patients with epilepsy

Bartłomiej Pawlicki, Zofia Maria Misztal, Mateusz Pawlicki, Anna Łopuszyńska, Magdalena Kozioł, Karol Lorenc, Damian Bator

Abstract


Ketogenic diet (KD) is a version of low-carbohydrate diet, that is rich in fat, but also contains enough protein and very low carbohydrates supply. This diet may be one of the treatment option for children with refractory epilepsy and studies show that it reduces seizures. KD may affect behavioural and cognitive functioning in children and adolescents with refractory epilepsy. The main weakness of KD are possible adverse side effects included drowsiness, constipation, weight loss, vomiting, gastroesophageal reflux, fever, hyperlipidaemia and elevated risk of kidney stones development.

Keywords


ketogenic diet; pediatric; epilepsy

Full Text:

PDF

References


Veech RL., The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mito-chondrial metabolism, Prostaglandins Leukot Essent Fatty Acids, 70, (2004), s.309-319.

Paoli A, Rubini A, Volek J S, Grimaldi K A, Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets, Eur J Clin Nutr, Aug; 67(8), (2013), s. 789-796.

Krikorian R., Shidler M. D., Dangelo K., Couch S. C., Benoit S. C., Clegg D. J., Dietary Ketosis Enhances Memory in Mild Cognitive Impairment, Neurobiology of aging 33.2 (2012), 425.e19-425.e27.

Drenick E. J., Alvarez L. C., Tamasi G. C., Brickman A. S., Resistance to Symptomatic Insulin Reactions after Fasting, Journal of Clinical Investigation 51.10 (1972), s. 2757-2762.

Swanson D, Block R, Mousa SA, Omega-3 fatty acids EPA and DHA: health benefits throughout life, Adv Nutr., (2012) Jan;3(1), s.1-7.

Hauser W. A., Epidemiology of Epilepsy in Children, Pellock’s Pediatric Epilepsy: Diagnosis and Therapy. Demos Medical; ISBN: 9781620700730; 2017; 177:205

Dhiman V, Molecular Genetics of Epilepsy: A Clinician's Perspective. Annals of Indian Academy of Neurology. 2017; Apr-Jun;20(2):96-102

Wheless J.W. Clarke D.F., Carpenter D. Treatment of Pediatric Epilepsy: Expert Opinion. Journal of Child Neurology. ISSN: 0883-0738; 2005; 20:1:1-56.

Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, Whitney A, Cross JH. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008 Jun;7(6):500-6.

Sharma S, Gulati S, Kalra V, Agarwala A, Kabra M. Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy--Indian experience. Seizure. 2009 Jul;18(6):446-9.

Titre-Johnson S, Schoeler N, Eltze C, Williams R, Vezyroglou K, McCullagh H et al. Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial Trials. 2017:26;18(1):195.

Ramírez-Camacho A., Meavilla S., Catalán N., Gutiérrez A., Campistol J., Experience with ketogenic diet as treatment for refractory epilepsy, Rev Neurol. 2011 1;53(9):524-30.

Coppola G, Verrotti A, Ammendola E, Operto FF, Corte RD, Signoriello G, Pascotto A., Ketogenic diet for the treatment of catastrophic epileptic encephalopathies in childhood. Eur J Paediatr Neurol. 2010 May;14(3):229-34.

Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G et al.. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia. 2009;50(5):1109-17.

Evangeliou A., Spilioti M., Doulioglou V., Kalaidopoulou P., Ilias A., Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis. J Child Neurol. 2009 ;24(10):1268-72.

IJff DM, Postulart D, Lambrechts DA, Majoie MH, de Kinderen RJ et al. Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial. Epilepsy Behav. 2016;60:153-157.

Christodoulides S.S., Neal E.G., Fitzsimmons G., Chaffe H.M., Jeanes Y.M., Aitkenhead H., Cross J.H., The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels. J Hum Nutr Diet. 2012;25(1):16-26.

Zamani GR, Mohammadi M, Ashrafi MR, Karimi P, Mahmoudi M, Badv RS et al. The effects of classic ketogenic diet on serum lipid profile in children with refractory seizures. Acta Neurol Belg. 2016;116(4):529-534.

Nizamuddin J, Turner Z, Rubenstein JE, Pyzik PL, Kossoff EH, Management and risk factors for dyslipidemia with the ketogenic diet. J Child Neurol. 2008 Jul;23(7):758-6

Sampath A, Kossoff EH, Furth SL, Pyzik PL, Vining EP. Kidney stones and the ketogenic diet: risk factors and prevention. J Child Neurol. 2007;22(4):375-8.

De Kinderen R.J., Lambrechts D.A., Postulart D., et al. Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial. BMC Neurology. 2011;11:10.

De Kinderen R.J. Lambrechts Wijnen D.A., Postulart D., Aldenkamp A.P., Majoie M., Evers S.M., An economic evaluation of the ketogenic diet versus care as usual in children and adolescents with intractable epilepsy: An interim analysis Epilepsia, 2015; 57(1):41-50.




DOI: http://dx.doi.org/10.5281/zenodo.3337385

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)