The role of irisin in ischemic heart disease

Patrycja Agata Piątek, Anna Fabian-Danielewska, Katarzyna Korabiusz, Monika Stecko, Agata Wawryków, Wojciech Witkiewicz, Paweł Stachowiak, Jarosław Gorący

Abstract


Introduction: Physical effort has a positive effect on the human body, through its protective effect on the development of many diseases, along with cardiovascular system diseases. Irisin is an adipomiokine that is a fragment of the doemeny of extracellular FNDC5 protein.
It is released from FNDC5 due to physical activity and peroxisome proliferator receptor-γ coactivator 1α (PGC-1α) stimulation. It forms a link between the muscles and other tissues
of the body. Moreover, it affects the conversion of white adipose tissue into
brownish-like fat tissue.
Aim: For over 15 years ischemic heart disease has been one of the most common causes
of death in the world. Therefore, attempts have been made to clarify the role it has in ischemic heart disease.
Conclusions: It has been proven, that the concentration of irisin decreases in patients
with myocardial infarction it also correlates with the severity of stable coronary disease
and a higher SYNTAX score. Hence, the hypothesis was that the level of this protein probably depends on the inflow of blood to the myocardium. It can therefore be used for the panel
of myocardial damage. The New Approach of therapeutic options uses irisin with stem cells during the repairing of myocardium. Despite much interest in irisin, there are still many questions that need to be answered, in particular those related to the irisin cell receptor
and what is related to the clarification of its mechanisms in physiology.

Keywords


irisin; ischemic heart disease; metabolizm

Full Text:

PDF

References


Pukajło K., Kolackov K., Łaczmańsk Ł., Daroszewski J.: Irisin – a new mediator of energy homeostasis. Advances in Hygiene and Experimental Medicine. 2015; 69: 233-242.

World Health Organisation. The top 10 causes of Heath [online]. WHO. [Przeglądany 24 czerwca 2019]. Dostępny w: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death.

Kuloglu T., Aydin S., Eren M.N., Yilmaz M., Sahin İ., Kalayci M., et al.: Irisin: A potentially candidate marker for myocardial infarction. Peptides. 2014. 55:85–91.

Emanuele E., Minoretti P., Pareja-Galeano H., Sanchis-Gomar F., Garatachea N, Lucia A. :Serum Irisin Levels, Precocious Myocardial Infarction, and Healthy Exceptional Longevity. Am J Med. 2014. 127(9):888–90.

Zhang Y., Song H., Zhang Y., Wu F., Mu Q., Jiang M., et al.: Irisin Inhibits Atherosclerosis by Promoting Endothelial Proliferation Through microRNA126‐5p. J Am Heart Assoc. 2016. 5(9).

Efe T.H., Açar B., Ertem A.G., Yayla K.G., Algül E., Yayla Ç., et al. Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina. Korean Circ J. 2017.47(1):44.

Anastasilakis A.D., Koulaxis D., Kefala N., Polyzos S.A., Upadhyay J., Pagkalidou E., et al.:Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy. Metabolism. 2017.73:1–8.

Guo W., Zhang B., Wang X.: Lower irisin levels in coronary artery disease: a meta-analysis. Minerva Endocrinol. 2017.

Aydin S., Catak Z., Eren M.N., Topal A.E., Aydin S.: Irisin in Coronary Bypass Surgery. Cardiovasc Hematol Disord Targets. 2018.18(3):208–14.

Hsieh I.C., Ho M.Y., Wen M.S., Chen C.C., Hsieh M.J., Lin C.P., et al.: Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction. Int J Cardiol. 2018 . 261:12–7.

Zhao Y.T., Wang J., Yano N., Zhang L.X., Wang H., Zhang S., et al.: Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart. J Cell Physiol. 2019. 234(2):1671–81.




DOI: http://dx.doi.org/10.5281//zenodo.3265182

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)