Dysbiosis and depressive disorders. Survey review

Inga Janik, Martyna Maciejewska, Katarzyna Korabiusz, Agata Wawryków, Agnieszka Wilczyńska, Monika Stecko, Anna Fabian-Danielewska


A significant increase in the incidence of depression, change of lifestyle and nutrition, forces researchers to seek understanding of the various mechanisms of the formation of such a disorder. Numerous studies draw attention to dysbiosis - a disorder of the composition and function of the intestinal microflora. In current studies, strong correlations can be observed between microbiota disorders and the occurrence of autoimmune and inflammatory diseases.


microbiota; gut–brain axis; depression

Full Text:



World Health Organization (2012). Public health action for the prevention of suicide.

Elomaa, A. P., Niskanen, L., Herzig, K. H., Viinamäki, H., Hintikka, J., Koivumaa-Honkanen, H., .& Lehto, S. M. (2012). Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. BMC psychiatry, 12(1), 2.

Schroeder, B. O., & Bäckhed, F. (2016). Signals from the gut microbiota to distant organs in physiology and disease. Nature medicine, 22(10), 1079.

Gonzalez, A., Stombaugh, J., Lozupone, C., Turnbaugh, P. J., Gordon, J. I., & Knight, R. (2011). The mind-body-microbial continuum. Dialogues in clinical neuroscience, 13(1), 55.

Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018). Anxiety, depression, and the microbiome: a role for gut peptides. Neurotherapeutics, 15(1), 36-59.

Pace, T. W., Hu, F., & Miller, A. H. (2007). Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain, behavior, and immunity, 21(1), 9-19.

Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008). The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. Journal of psychiatric research, 43(2), 164-174.

Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by ma-ternal separation. Gut 2007; 56: 1522–1528.

Iyer, L. M., Aravind, L., Coon, S. L., Klein, D. C., & Koonin, E. V. (2004). Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role?. TRENDS in Genetics, 20(7), 292-299.

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X. N., ... & Koga, Y. (2004). Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice. The Journal of physiology, 558(1), 263-275.

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X. N., ... & Koga, Y. (2004). Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice. The Journal of physiology, 558(1), 263-275.

Hannestad, J., DellaGioia, N., & Bloch, M. (2011). The effect of antidepressant medica-tion treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsy-chopharmacology, 36(12), 2452.

Rutkowski R., Pacewicz S., Skrzydlewska T. i wsp. Właściwości biologiczne czynnika transkrypcji jądrowej. Alergia Astma Immunologia 2005; 10: 125-131.

Xu, Y., Ku, B., Cui, L., Li, X., Barish, P. A., Foster, T. C., & Ogle, W. O. (2007). Curcu-min reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain research, 1162, 9-18.

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., ... & Petters-son, S. (2011). Normal gut microbiota modulates brain development and behavior. Procee-dings of the National Academy of Sciences, 108(7), 3047-3052.

Benton, D., Williams, C., & Brown, A. (2007). Impact of consuming a milk drink contai-ning a probiotic on mood and cognition. European journal of clinical nutrition, 61(3), 355.

DOI: http://dx.doi.org/10.5281/zenodo.3256715


  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014


POL-index 2011 - 2014


BASE 2011 - 2014




Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI


Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland






Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.


ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski