Copeptin and NTproBNP in patients with acute Q - myocardial infarction complicated by acute heart failure with hyperglycemia on admission

Victor Syvolap, Nataliya Kapshytar

Abstract


Introduction. Acute heart failure is a complication of Q-myocardial infarction that affects the acute period and long-term outcome of the disease. The study of new predictors and outcomes of acute heart failure remains an urgent problem. Objective. To assess the levels of copeptin and NTproBNP in acute period of Q - myocardial infarction complicated by acute heart failure with hyperglycemia (HG) on admission. Materials and methods. The study involved 139 patients with acute MI Q-complicated by acute heart failure, who were divided into two groups: normoglycemia (n = 31) and HG on admission (n = 108). There were selected subgroups of HG: stress HG (n = 34), impaired glucose tolerance (IGT) (n = 26), new-onset type 2 diabetes (n = 25), type 2 diabetes mellitus (DM) in history (n = 23). The control group included 26 healthy individuals. The general clinical examination, echocardioscopy, continuous daily monitoring of ECG and blood pressure were performed, the levels of insulin, copeptin and NTproBNP were determined. Results. Compared with control group the patients with normoglycemia showed significantly higher level of copeptin on the first day by 27% (p = 0.03), in the group of HG on admission by 57% (p = 0.0001), in the stress HG group by 62% (p = 0.0001), in the group of new-onset diabetes by 49%
(p = 0,001), in DM type 2 in history by 54% (p = 0,01). In patients with stress HG copeptin by 49% (p = 0.02), and in patients with GH on admission it was 2.3 times higher than in the normoglycemia group. On the 12thday the copeptin level was significantly higher than the values in the control group by 56% (p = 0.0009) in patients with normoglycemia, by 51%
(p = 0,007) in group with the HG on admission, by 51% (p = 0.003) in stress HG patients. NTproBNP level was significantly higher that in the control on the first and 12th days in all groups. On the first day in patients with normoglycemia – 8,6 times (p = 0.00001), in group of HG on admission – 9,9 times (p = 0,00001), in stress HG patients – 11,2 times (p = 0.00001), in the group of IGT – 7,4 times (p = 0.0001), in patients with new-onset diabetes – 10,7 times (p = 0.00001), in the type 2 diabetes in history group – 12,2 times (p = 0.0001). On the 12th day NTproBNP level in patients with normoglycemia – 4.8 times (p = 0.001), in the group with HG on admission – 11.3 times (p = 0.00001), in stress HG – 11.1 times (p = 0.00001), in group of IGT – 12.8 times (p = 0.001), with new-onset diabetes – 7.14 times (p = 0.0002), in patients with DM type 2 in history – 11.7 times (p = 0.0001) higher than in the control group. In order to identify factors affecting the level of copeptin, a model of multiple linear regression was made. Conclusions. The most significant changes of copeptin were identified in groups of hyperglycemia on admission and stress HG. On the 12th day the increase of copeptin level, compared with the control group, retained in normoglycemia, hyperglycemia on admission and stress hyperglycemia patients. NTproBNP level was significantly increased in all patients, regardless of the presence and type of hyperglycemia. Systolic blood pressure in the pulmonary artery, the presence of the clinical manifestations of heart failure and hyperglycemia on admission have a predictive property, that allows to use them in the linear regression model to predict copeptin level.

Keywords


Q-myocardial infarction; acute heart failure; hyperglycemia; copeptin

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References


Kovalenko N.V., Chichkova M.A., Abdulkerimova A.A., Chichkov YU.M. Optimizatsiya lecheniya infarkta miokarda s pod"yemom segmenta ST na fone khronicheskoy gerpesvirusnoy infektsii. [Optimization of treatment of myocardial infarction with ST segment elevation against the background of chronic herpes virus infection]. Sovremennyye problemy nauki i obrazovaniya. 2016;5. http://www.science-education.ru/ru/article/view?id=25257 [Ukr.].

Mueller C1, Christ M2, Cowie M et al. European Society of Cardiology-Acute Cardiovascular Care Association Position paper on acute heart failure: A call for interdisciplinary care. Eur Heart J Acute Cardiovasc Care. 2017; 6(1):81-86. doi: 10.1177/2048872615593279.

Steg P.G., James S.K., Atar D. et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur. Heart J. 2012; 33(20): 2569–619. DOI: 10.1093/eurheartj/ehs215

Kolesnyk M. Ostryy ynfarkt myokarda: chto novoho? [Acute myocardial infarction: what's new?] Ukrayinsʹkyy medychnyy chasopys. 2017. URL: https://www.umj.com.ua/article/115273/ostryj-infarkt-miokarda-chto-novogo [Ukr.]

P. Ponikowski, A. A. Voors, S.D. Anker, H. Bueno et all ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2016; 37(27):2129-2200. doi: 10.1093/eurheartj/ehw128. Epub 2016 May 20.

Nickel C.H., Bingisser R., Morgenthaler N.G. The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department. BMC Med. 2012;10:7–14. doi: 10.1186/1741-7015-10-7.

Afzali D., Erren M., Pavenstädt H. J., et al. Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes. Clinical Research in Cardiology. 2013;102(10):755–763. doi: 10.1007/s00392-013-0583-0.

Folli Ch, Consonni D, Spessot M. et al. Diagnostic rolle of copeptin in patients presenting with chest pain in the emergency room. eur J of Internal Medicine 2013;24 (2):189-93. doi: 10.1016/j.ejim.2012.09.006. Epub 2012 Oct 9.

Searle J., Slagman A., Stockburger M. et al. Use of copeptin in emergency patients with cardiac chief complaints. Eur Heart J Acute Cardiovasc Care. 2015 Oct;4(5):393-402. doi: 10.1177/2048872614554197

Zhukova A.V., Arabidze G.G. Prognosticheskoye znacheniye kopeptina v razvitii tyazheloy serdechnoy nedostatochnosti u patsiyentov s ostrym koronarnym sindromom bez pod"yema segmenta ST [The prognostic value of copeptin in the development of severe heart failure in patients with acute coronary syndrome without ST-segment elevation.]. CardioSomatika. 2018;9(1):26–31. DOI: 10.26442/2221-7185_2018.1.26-31 [Rus.]

Berezin AE. Biological markers of cardiovascualr diseases. Part 4. Diagnostic and prognostic value of biological markers at risk stratification among patients with heart failure. LAMBERT Academic Publishing GmbH, Moscow, 2015. - 329 pp. DOI: 10.13140/RG.2.1.2027.9520 [Rus]

Moghissi E.S., Korytkowski M.T., DiNardo M. American Association of clinical endocrinologists and american diabetes association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32(6):1119–1131. https://doi.org/10.2337/dc09-9029

Lang R.M. Badano L.P., Mor-Avi V. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography. 2015; 28(1): 1–39. doi: 10.1016/j.echo.2014.10.003.

Svishchenko YE.P., Kovalenko V.M., Sirenko YU.M. ta inshi. Rekomendatsiyi Ukrayins’koyi Asotsiatsiyi kardiolohiv z profilaktyky ta likuvannya arterial’noyi hipertenziyi. Posibnyk do Natsional’noyi prohramy profilaktyky i likuvannya arterialʹnoyi hipertenziyi. Chetverte vydannya, vypravlene i dopovnene. [Recommendations of the Ukrainian Association of Cardiology for the prevention and treatment of arterial hypertension. A Guide to the National Program for the Prevention and Treatment of Arterial Hypertension. Fourth edition, corrected and supplemented]. Kyyiv, 2011 [Ukr]

Sychov O.S., Lutay M.I., Romanova O.M. ta in. Ambulatorne EK•H-monitoruvannya. Rekomendatsiyi Asotsiatsiyi kardiolohiv Ukrayiny. [Outpatient ECG monitoring. Recommendations of the Association of Cardiologists of Ukraine.] Kyyiv, 2010: 44 [Ukr].

Kravchun P.H., Yermak O.S., Ryndina N.H., Lytvynenko O.YU. Dynamika kopeptynu u khvorykh z hostrym infarktom miokarda zalezhno vid stupenya ozhyrinnya. [he dynamics of copeptin in patients with acute myocardial infarction, depending on the degree of obesity]. Visnyk problem biolohiyi ta medytsyny. 2014; 4(4): 91-94 [Ukr.]

Rajpathak S.N., Gunter M.J., Wylie-Rosett J. et al. The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes. Diabetes Metab Res Rev. 2009;25(1):3–12. doi: 10.1002/dmrr.919.

S. Goya Wannamethee, P. Welsh, O. Papacosta et al. Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men. The Journal of Clinical Endocrinology & Metabolism, Volume 2015;100(9):3332–3339. https://doi.org/10.1210/JC.2015-2362

Sorokyna E.Y. Ctress-yndutsyrovannaya hyperhlykemyya pry krytycheskykh sostoyanyyakh: kontseptsyya metabolycheskoy terapyy. [Stress-induced hyperglycaemia in critical conditions: the concept of metabolic therapy]. Bil’, znebolennya ta intensyvna terapiya. 2015;3:9-23 [Ukr].

Smaradottir M.I., Ritsinger V., Gyberg V., Norhammar A. et al. Copeptin in patients with acute myocardial infarction and newly detected glucose abnormalities - A marker of increased stress susceptibility? A report from the Glucose in Acute Myocardial Infarction cohort. Diab Vasc Dis Res. 2017;14(2):69-76. https://doi.org/10.1177/1479164116664490

V. D. Syvolap, N. I. Kapshytar. Predyktory rozvytku hostroyi sertsevoyi nedostatnosti u khvorykh u hostromu periodi Q-infarktu miokarda. [Predictors of acute heart failure in patients during the acute period of Q-wave myocardial infarction]. 2019. Zaporiz’kyy medychnyy zhurnal. 2019;2(113):160–164. DOI: 10.14739/2310-1210 [ Ukr.].

Hage C, Lund LH, Donal E. et al Copeptin in patients with heart failure and preserved ejection fraction: a report from the prospective KaRen-study. Open Heart. 2015;2:e000260. doi:10.1136/openhrt-2015-000260

Morgenthaler NG. Copeptin: A biomarker of cardiovascular and renal function. Congest Heart Fail. 2010;16(1):37–44. DOI: 10.1111/j.1751-7133.2010.00177.x

Kelly D, Squire IB, Khan SQ, et al. C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction. J Card Fail. 2008;14(9):739–745. doi: 10.1016/j.cardfail.2008.07.231

N.P. Nickel, R. Lichtinghagen, H. Golpon et al. Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension. Respir Res. 2013; 14(1): 130. doi: 10.1186/1465-9921-14-130

Silva Marques J, Martins SR, Calisto C et al. An exploratory panel of biomarkers for risk prediction in pulmonary hypertension: emerging role of CT-proET-1. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 2013;32:1214–1221. doi: 10.1016/j.healun.2013.06.020.

A. Holmström, R. Sigurjonsdottir, M.L.X. Fu, D. Gustafsson et al. Levels of copeptin among elderly patients in relation to systolic heart failure and heart failure with normal ejection fraction. European Geriatric Medicine. 2013;4(3): 139-144. Doi : 10.1016/j.eurger.2013.02.007

J. S. Marquesa, H. Luz-Rodriguesb, C. Davida et al. Biomarkers of functional class in systolic heart failure: The relevance of copeptin. 2012;31(11):687-762. DOI: 10.1016/j.repce.2012.04.020.




DOI: http://dx.doi.org/10.5281/zenodo.3246859

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