The experimental modelling of stress urinary incontinence

O. I. Iatsyna, R. S. Vastyanov, I. M. Savytska, S. V. Vernygorodskyi


The stress urinary incontinence (SUI), especially in women, constitutes most frequent complication of urogynecological diseases. Adequate and a stable reproducible model of SUI in white laboratory rats was created, using bilateral ligature of pudendal nerves. This guarantees a stable signs of SUI, which had progressed while the experiment duration enhanced. In accordance to the urodynamical investigations data, the leak pressure of the urine first drop in operated laboratory animals was registered; results of histological and morphometric investigations had witnessed about the ureter's diameter enhancement and the muscles tone lowering. In accordance to the investigation data, the ureter's and its sphincter denervation was stable, and the model application had permitted to obtain stable reproducible results.
The received model meets the requirements for qualitative indicators in the study of morphological changes in hyperactive urinary bladder model and can be used as a basis in the preclinical stage of research. The results of pathomorphological studies with revealed peculiarities of rearrangement of collagen fibers, degenerative changes of the elastic in the target organ, taking into account the anatomic-functional orientation of action, form the basis for further clarification of the mechanisms of occurrence and determination of the SUI recurrence.


stress urinary incontinence; experimental modeling; rats; urodynamics

Full Text:



Parsons B.A., Drake M.J. Animal models in overactive bladder research. Handb. Exp. Pharmacol. 2011; 202: 15-43.

Maestro N.A., Almodóvar C.M.J., Saavedra Q.V., Barreda V.C., Jamart S.L. Mirabegron, a breakthrough in overactive bladder syndrome? Farm. Hosp. 2017; 41(3): 410-422.

Moraes R.P., Silva J.L.D., Calado A.A., Cavalcanti G.A. Validation of the urgency questionnaire in Portuguese: A new instrument to assess overactive bladder syndrome. Int. Braz. J. Urol. 2018; 44(2): 338-347

Wróbel A.F., Kluz T., Surkont G., Wlaźlak E., Skorupski P., Filipczak A., Rechberger T. Novel biomarkers of overactive bladder syndrome. Ginekol. Pol. 2017; 88(10): 568-573.

Lai H.H., Munoz A., Smith C.P. Boone T.B., Somogyi G.T. Plasticity of non-adrenergic non-cholinergic bladder contractions in rats after chronic spinal cord injury. Brain Res Bull. 2011; 86(1-2): 91-6.

Munoz A., Boone T.B., Smith C.P., Somogyi G.T. Diabetic plasticity of non-adrenergic non-cholinergic and P2X-mediated rat bladder contractions. Brain Res Bull. 2013; 95:40-5.

Birder L., Andersson K.E. Urothelial signaling. Physiol Rev. 2013;93(2):653-80.

Andersson K.E., McCloskey K.D. Lamina propria: the functional center of the bladder? Neurourol Urodyn. 2014;33(1):9-16.

Kurosch M., Mager R., Gust K., Brandt M., Borgmann H., Haferkamp A. Diagnosis of overactive bladder (OAB). Urologe A. 2015; 54(3): 421-7.

Drake M.J., Mills I.W., Gillespie J.I. Model of peripheral autonomous modules and a myovesical plexus in normal and overactive bladder function. Lancet. 2001; 358(9279): 401-3.

Sadananda P., Drake M.J., Paton J.F. A functional analysis of the influence of β3-adrenoreceptors on the rat micturition cycle. J. Pharmacol. Exp. Ther. 2013; 347(2): 506-15.

Drake M.J., Fowler C.J., Griffiths D. Neural control of the lower urinary and gastrointestinal tracts: supraspinal CNS mechanisms. Neurourol. Urodyn. 2010; 29(1): 119-27.



  • There are currently no refbacks.

Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski