Efficacy of pharmacotherapy according to laser correlation spectrometry in elderly with arterial hypertension and comorbid pathology

N. V. Tofan, V. B. Iablonska, O. V. Khyzhnyak, O. Yu. Nigreskul, S. A. Novikov


In patients with arterial hypertension (AH) pharmacotherapy often remains ineffective because of comorbid pathology. Research of haemodynamic and homeostatic processes in such patients allows prescribe effective antihypertensive medicines, improve life quality and prognosis. Material and methods: 60 patients with AH, coronary artery disease and obesity were divided into three groups: 1st group was treated with lisinopril + atorvastatin + aspirin (regimen I); 2nd group was treated with lisinopril + atorvastatin + bisoprolol + aspirin (regimen II); 3rd group was treated with lisinopril + bisoprolol + indapamide + atorvastatin + aspirin (regimen III). Laser correlation spectrometry (LCS) was used to evaluate the homeostatic alterations. Results: All regimens were equally effective in normalization of systolic blood pressure and did not influence the ejection fraction. Only in the 3rd group was determined significant increase of glomerular filtration rate (92.732.12 vs 79.6213.62 ml/min/1.73m2). The LCS test showed that these patients had high level of light scattering particles IV, which may be caused by activation of anabolic processes. In other groups, spectral alterations were not so expressive. Conclusions: Prescription of antihypertensive therapy cause homeostatic and metabolic alterations, which may influence the efficacy of treatment.


pharmacotherapy; comorbid pathology; laser correlation spectrometry

Full Text:



Kovalenko VM, Kornatsky VM. Regional features of health level of the Ukraine people. Analytic and statistical manual. Kiev, 2013.

Baguet JP, Barone-Rochette G, Mallion JM. Hypertension and coronary heart disease. European Society of Hypertension Scientific Newsletter: Update on Hypertension Management. Via Medica 2012: 25-26.

Lutay MI, Sirenko YM, Materials of the Ukranian scientific conference «Prophylaxis and treatment of arterial hypertension in Ukraine. Ukrainian cardiologic magazine (Addition 1) 2010, 6-22.

Kovalenko VM, Lutay MI, Sirenko YM. Cardio-vascular diseases. Classification, standards of diagnostics and treatment of cardiologic patients. Kiev, 2011.

Thomas F, Bean K, Pannier B. Cardiovascular mortality in overweight subjects. The key role of associated risk factors. Hypertension 2005; 46: 654-663.

Shtanko VA, Tofan NV. Comorbidity structure and combined pharmacotherapy features in coronary artery disease combined with primary hypertension in the elder. Achievements of biology and medicine 2013; 1: 47-51.

Simone de G. Morbid obesity and left ventricular geometry. Hypertension 2007; 49(1): 7-9.

Mezentseva NV, Leonov MV, Belousov YB. Evaluation of efficiency and safety of the combined hypotensive therapy in patients with an arterial hypertension combined with coronary artery disease. Arterial hypertension 2005; 11 (4): 257-261.

Lazebnik LB. Aging and polymorbidity. Consilium medicum 2005; 12: 993-996.

Kjeldsen SE, Stenehjem AE, Os I, Hedner T. Treatment of high blood pressure in the elderly. European Society of Hypertension Scientific Newsletter: Update on Hypertension Management. Via Medica 2012: 57-58.

Lupanov VP. Treatment of arterial hypertension in the patients with coronary artery disease. Russian medical journal 2002; 1: 26–32.

Arkhipova EN, Ezhova OA, Alchinova IB. Integrated method of an assessment of condition of organism protective systems. Pathogenesis 2008; 6(1): 23-27.

Bazhora YI, Noskin LA. Laser correlation spectroscopy in medicine. Odessa: Druk, 2002.

Bazhora YI, Kresyun VI, Noskin LA. Laser correlation spectroscopy of biological liquids in a practical health protection: methodical recommendations. Odessa: Odessa state medical university, 2003.

Ukraine Ministry of Health. Order № 384 from 24 May 2012. Arterial hypertension. Updated and adapted clinical recommendation, evidence based. Available from:


Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S. et al. Chronic Kidney Disease Epidemiology Collaboration. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006; 145(4): 247–254.

Fox K. Garcia MA, Ardissino D, Buszman P, Camici PG, Crea F. et al. Guidelines on the management of stable angina pectoris — executive summary. The Task Force on the Management of stable angina pectoris of the European Society of Cardiology Eur Heart J 2006; 27 (11): 1341-1381.

Мansia G, Laurent S, Agabiti-Rosei E. European Society of hypertension. Reapprisal of European guidelines on hypertension management: a European Society of hypertension task forse document. J. Hypertens 2009; 27: 2121-2158. Available from: www.ish.org.il/2009GuidelinesESH.pdf.

Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Bohm, M., et al. ESH/ESC Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal 2013; 34: 2159-2219. Available from: http://dx.doi.org/10.1093/eurheartj/eht151.

DOI: http://dx.doi.org/10.5281/zenodo.3241770


  • There are currently no refbacks.

Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014


POL-index 2011 - 2014


BASE 2011 - 2014




Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI


Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland






Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.


ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski