The article presents data on the effect of silicon-containing mineral waters (MW) and their artificial analogues with the corresponding content of metasilicic acid on the state of the stomach wall in the modeling of gastritis in white rats. It was established that the use of MW with different content of metasilicic acid has a unidirectional, positive effect on the course of gastritis. MW with greater mineralization, molarity and high content of methacrylic acid completely eliminate inflammation and moderately stimulate reparative processes.
In the application of MW with less mineralization, molarity and lower content of metasilicic acid, there were definitive inflammation manifestations, but the manifestations of reparative processes were more pronounced. The same trend was observed with the use of artificial analogues - model solutions on distilled water with the corresponding content of metasilicic acid. It is determined the same restorative in the direction, but much weaker corrective effect than the corresponding MW. The important component of the corrective action of these silicon MW when used in animals with gastritis is determined by the peculiarities of the macro component composition and the proportion of the main macro components - Na +, K +, Mg2 +, Ca2 +, НСО3, Cl-, SO42- and, to a lesser extent, silicon content.

silicon-containing mineral waters, gastrointestinal tract, metasilicic acid

Sipponen Р, Maaroos НI. Chronic gastritis. Scand J Gastroenterol. 2015; 50(6): 657–667. doi: 10.3109/00365521.2015.1019918.

Suzuki Н, Mor Н. Different Pathophysiology of Gastritis between East and West? An Asian Perspective. Inflamm Intest Dis. 2016; 1:.123–128.

Dragomeretskaya NV, Zabolotnaya IB, Izhza AV, Shevchenko NA, Kalinichemko NV. Early rehabilitation of the patients presenting with digestive organ diseases based at a spa and health resort: the 30 year experience and prospects for further development. Physiotherapy, balneotherapy, rehabilitation. 2013; 3: 19–22.

Du Y, Bai Y, Xie P, Fang J, Wang X, Hou X, Tian D, Wang C [et al]. Chronic gastritis in China: a national multi-center survey. BMC Gastroenterology. 2014; 14: 21. doi: 10.1186/1471-230X-14-21.

Report of the Kyoto international consensus on gastritis associated with the Helicobacter pillory. Modern Gastrornterology. 2016; 1 (87): 35–53.

Telaranta-Keerie A, Kara R, Paloheimo L, Härkönen M, Sipponen P. Prevalence of undiagnosed advanced atrophic corpus gastritis in Finland: an observational study among 4,256 volunteers without specific complaints. Scand J Gastroenterol. 2010;45:1036–41.

Bilash SM. Morphometric characteristics of cardia gastric wall of intact rats with, acute gastritis, when using the drug "Plateks placenta" and their combined action. World of medicine and Biology. 2012; (3): 7-10.

Dorofeev AE, Rudenko NN. Treatment of gastropathy associated with taking nonsteroidal anti-inflammatory drugs. The place of omeprazole (according to the materials of the conferences Gastrosphere 1.0 and 2.0). Journal of Gastroenterology. 2017; 51 (1). http://www.mif-ua.com/archive/issue-34568/.

Filippov YuA., Zak МYu. The modern paradigm of chronic gastritis associated with biliary reflux. Modern Gastrornterology. 2018; 2(100): 95–103.

Muszyński J, Ziółkowski B, Kotarski P, Niegowski A, Górnicka B, Bogdańska M, Ehrmann-Jóśko A, Zemlak M, Młynarczyk-Bonikowska B, Siemińska J. Gastritis – facts and doubts. Prz Gastroenterol. 2016; 11(4): 286–295. doi: 10.5114/pg.2016.57793.

Fedulova LE, Sorokina AA. Correlation of experimental gastritis with hematological indices of blood. Eurasian Union of Scientists, biological sciences. 2015; 7(16): 117–120.

Nasibullin BA, Gushcha SG,Yaroshenko NA, Оleswhkо AYa, Baholdina EІ, Каlіnіchеnко МV. Complex assessment of parameter changes of homeostasis in rats with experimental gastrites. J. Clin. Exp. Med. Res. 2017; 5(1): 713–719.

Zub LО, Klugin VO, Vivsiynik VV. Pathogenetic substantiation of some mechanisms of occurrence of erosive-ulcerative stomach lesions in patients with chronic kidney disease of ІІ-ІІІ stages. Galician Medical Journal. 2009;16(1): 38–39.

Luo J, Wang Т, Liang S, Hu X, Li W, Jin F. Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats. Behav. Brain Funct. 2013; 9(46). Retrieved from: https://www.ncbi.nlm.nih.gov/pms/articles/PMC3878489/.

Ruggiero P. Helicobacter pylori and inflammation. Curr Pharm. Des. 2010; 16(38): 4225–4236.

Basir НRG, Ghobakhlou ММ, Akbari Р, Dehghan А, Seif MAR. Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis. Gastroenterology Research and Practice. 2017; Retrieved from: https://doi.org/10.1155/2017/8320496.

Larauche М, Anton Р, Garcia-Villar R, Theodorou V, Frexinos J, Buéno L, Fioramonti J. Protective effect of dietary nitrate on experimental gastritis in rats. Br. J. Nutr. 2003; 89(6): 777–788.

Bhardwaj V, Bhardwaj R, Krishna RBV, Sharma PL. Investigation of Gastroprotective Potential of Grape Seed Proanthocyanidin Exract in Experimental Models of Gastric Ulcer, in Wistar Rats. J Gastrointest Dig Syst. 2018; 8(2): 561. doi: 10.4172/2161-069Х,1000561.

Stefanov AV. Preclinical studies of drugs: Methodic recommendations / Kiev: Avicena, 2002: 567 p.

Painsipp Е. Wultsch Т. Shahbazian А, Edelsbrunner M, Kreissl MC, Schirbel A, Bock E, Pabst MA, Thoeringer CK, Huber H.P, Holzer P. Experimental gastritis in mice enhances anxiety in a gender-related manner. Neuroscience. 2007; 150(3): 522–536.

Komleva NE, Maryanovsky AA, Danilov AN, Agasarov LG. The novel approaches to the rehabilitation of the patients presenting with gastroesophagel reflux disease and co morbid pathology. Questions of balneology, physiotherapy and physical therapy. 2017; 2: 20–23.

Zolotareva TA, Babov KD, Nasibullin BA [et al]. Medical rehabilitation. – Кiev: КІМ, 2012: – 496 р.

Alekseenko NA, Babov KD, Gushcha SG [et al]. New Niniv mineral water resort of Morshyn: monograph / By red. Babov KD, Nikipelova EM, Tokaria I.M. – Drohobych: Kolo, 2012: 148 p.

Lemko IS, Feksishgasi BM, Kirtich LP [et al]. Microelement composition of mineral waters and medical-geographical regionalization of Zakarpatiy. Medical hydrology and rehabilitation. 2005; 3(2): 4–13.

Mineral waters of Ukraine / Ed. By Кolesnik Е.О., Bабоv К.D. – Кiev: Кuрrіyanovа, 2005, 576 р.

Gushcha SG, Nasibullin BA, Plakida AL, Trubka IА, Volyanskaya VS, Kalinichenko NV, Balashova IV. Comprehensive assessment of functional changes in the organism of healthy rats in external and internal use of silicone malomineralized mineral water. European Journal of Clinical and Biomedical Sciences. 2018; 4(1): 1–5. doi: 10.11648/j.ejcbs.20180401.11

Gushcha SG, Nasibullin BA, Plakida АL, Kalinichenko VN, Tikhokhod LV, Mohylevska TV. Pathogenetic and sanogenetic mechanisms of the influence of mineral waters (siliconed and with increased organic substances) of different osmularity on the exposure of toxic nephritis Journal of Biotechnology and Bioengineering. 2018; 2(2):.7–12.

Kozhemyakin YuN, Khromov OS, Boldyreva NE, Dobrelya NV, Sayfetdinova GA. Scientific and practical recommendations for the maintenance of laboratory animals and work with them: monograph. – Кiev: Interservice, 2017: 182 р.

Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes (Text with EEA relevance), Official Journal. 2010; 276: 0033–0079.

Order of Ministry of Education and Science, Youth and Sport of Ukraine No. 249 dated 01.03.2012. Official Journal of Ukraine dated 06.04.2012, article 942, № 24, 82 р., code of the act 60909/2012.

Nasibullin BA, Gushcha SG, Babov KD, Trubka IA, Оleshko AYa, Baholdina EІ. Guidance on the reproduction of experimental models of common nosological forms and their verification. – Odesa: POLIGRAF, 2018: 82 р.

On approval of the recommendations of the research methods of biological effects of natural medical resources and preformed medicines: MOH of Ukraine № 692, from 28.09.09. Kiev: 2009.