Wine health properties

Grzegorz Borenski, Magdalena Wójcik, Julita Poleszak, Przemysław Szabat, Marta Szabat, Joanna Milanowska


Introduction: Wine is worldwide known drink with a long history. It is popular in many cultures and diets. It is a component of Mediterranean diet, which is an example of healthy eating. Red wine seems to be an essential component of the diet, since moderate consumption of wine is associated with lower risk and mortality from cardiovascular disease.
The aim of the study: The purpose of this systemic review was to collect and analyse available data about health properties of wine.
Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed database was carried out using the following keywords: wine, alcohol, cardiovascular, polyphenols.
Description of the state of knowledge: Pro-health properties of alcohol depends mainly on the content of polyphenols. The most biologically active polyphenol is resveratrol. Light drinking of wine has multiple beneficial effects. It decreases level of total plasma cholesterol, low-density lipoprotein and increases high-density lipoprotein, lowers blood fibrinogen, thromboxane A, platelet stickiness, reducing insulin resistance, inhibits inflammation, improves endothelial function, fibrinolysis and increases plasma concentration of atrial natriuretic peptide. In addition it may have neuroprotective effect and beneficial effect on gut microbiota.
Summary: Moderate wine consumption can be beneficial for our health, may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders and metabolic syndrome. Nevertheless, any amount of alcohol consumed can lead to alcohol addiction and there is a very thin line between drinking small amounts and abuse. Furthermore, there are studies indicating that small amounts of alcohol can also have a negative impact on health. This subject still needs more studies and clinical trials.


wine; polyphenols; alcohol

Full Text:



Snopek L, Mlcek J, Sochorova L, Baron M, Hlavacova I, Jurikova T, et al. Contribution of Red Wine Consumption to Human Health Protection. Molecules. 201823(7):1684.

Amor S, Châlons P, Aires V, Delmas D. Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers. Diseases. 20186(4):106.

Grønbaek M, Deis A, Sørensen TI, Becker U, Schnohr P, Jensen G. (1995). Mortality associated with moderate intakes of wine, beer, or spirits. BMJ. 1995310(6988):1165–1169.

Sureda X, Carreño V, Espelt A, Villalbí JR, Pearce J, Franco M. Alcohol in the city: wherever and whenever. Gaceta sanitaria. 201832:172-175.

Chawla R. Regular drinking might explain the French paradox. BMJ. 2004329(7478):1308.

Markoski MM, Garavaglia J, Oliveira A, Olivaes J, Marcadenti A. Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits. Nutrition and metabolic insights. 20169:51–57.

Fernandes I, Pérez-Gregorio R, Soares S, Mateus N, de Freitas V. Wine Flavonoids in Health and Disease Prevention. Molecules. 201722(2):292.

Waterhouse AL. Wine phenolics. Annals of the New York Academy of Sciences. 2002957(1):21-36.

Stephan LS, Almeida ED, Markoski MM, Garavaglia J, Marcadenti A. Red Wine, Resveratrol and Atrial Fibrillation. Nutrients. 20179(11):1190.

Davies J, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, et al. The Oxygen Paradox, the French Paradox, and age-related diseases. GeroScience. 2017 39(5-6):499–550.

Arranz S, Chiva-Blanch G, Valderas-Martínez P, Medina-Remón A, Lamuela-Raventós RM, Estruch R. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients. 20124(7):759–781.

Woo HD, Kim J. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PloS one. 2013 8(9):e75604.

Woo HD, Kim J. Dietary flavonoid intake and risk of stomach and colorectal cancer. World journal of gastroenterology. 201319(7):1011–1019.

Smeriglio A, Barreca D, Bellocco E, Trombetta D. (2016). Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects. British journal of pharmacology. 2016174(11):1244–1262.

Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J. Bioactive Compounds and Antioxidant Activity in Different Types of Berries. International journal of molecular sciences. 201516(10):24673–24706.

Stanevičienė I, Mongirdienė A, Bernatonienė J. Multiplicity of effects and health benefits of resveratrol. Medicina. 201652(3):148-155.

Kulkarni SS, Cantó C. The molecular targets of resveratrol. Biochimica et BiophysicaActa (BBA)-Molecular Basis of Disease. 20151852(6):1114-1123.

Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 20168(5):250.

Riba A, Deres L, Sumegi B, Toth K, Szabados, E, Halmosi R. Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model. Oxidative medicine and cellular longevity.20172017:6819281.

Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini

B, Davis JG, et al. Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium. International journal of cardiology. 2012166(1):246–248.

Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, et al. The Role of Resveratrol in Cancer Therapy. International journal of molecular sciences. 201718(12):2589.

Yousef M, Vlachogiannis IA, Tsiani E. Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies. Nutrients. 20179(11):1231.

Oliveira A, Monteiro V, Navegantes-Lima KC, Reis JF, Gomes RS, Rodrigues D, et al. Resveratrol Role in Autoimmune Disease-A Mini-Review. Nutrients. 2017 9(12):1306.

Szkudelski T, Szkudelska K. Resveratrol and diabetes: from animal to human studies. Biochimica et BiophysicaActa (BBA)-Molecular Basis of Disease. 20151852(6):1145-1154.

Sun AY, Wang Q, Simonyi A, Sun GY. Resveratrol as a therapeutic agent for neurodegenerative diseases. Molecular neurobiology. 201041(2-3):375–383.

Gresele P, Cerletti C, Guglielmini G, Pignatelli P, de Gaetano G, Violi F. Effects of resveratrol and other wine polyphenols on vascular function: An update. J. Nutr. Biochem. 2011 22:201–211.

Klatsky AL. Alcohol and cardiovascular health. Physiol. Behav. 2010 100:76–81.

Djoussé L, Gaziano JM. Alcohol consumption and heart failure: a systematic review. Current atherosclerosis reports. 200810(2):117–120.

Torres Duarte AP, Dong QS, Young J, Abi-Younes S, Myers AK. Inhibition of platelet aggregation in whole blood by alcohol. Thromb Res. 1995 78:107–115.

Imhof A, Woodward M, Doering A, Helbecque N, Loewel H, Amouyel P, et al. Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille).Eur Heart J. 2004 25:2092–2100.

Xia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. British journal of pharmacology. 2016174(12):1633–1646.

Mizutani K, Ikeda K, Kawai Y, Yamori Y. Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. J NutrSciVitaminol. 2000 46(2):78-83.

Juhasz B, Das DK, Kertesz A, Juhasz A, Gesztelyi R, Varga B. Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, longevinex. [corrected]. Mol Cell Biochem. 2011 348(1-2):199-203.

Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM., Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels.Int J Mol Med. 2005 16(4):533-40.

Andreadou I, Iliodromitis EK, Rassaf T, Schulz R, Papapetropoulos A, Ferdinandy. The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. British journal of pharmacology. 2014172(6):1587–1606.

Su HC, Hung LM, Chen JK, Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats.Am J PhysiolEndocrinolMetab. 2006 290(6):E1339-46.

Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ. 2011 342:d671.

Costanzo S, Di Castelnuovo A, Donati MB, Iacoviello L, de Gaetano G. Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: A meta-analysis. Eur. J. Epidemiol. 2011 26:833–850.

Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, De Gaetano G., Meta-analysis of wine and beer consumption in relation to vascular risk.Circulation. 2002 105(24):2836-44.

Renaud SC, Guéguen R, Siest G, Salamon R. Wine, beer, and mortality in middle-aged men from eastern France.Arch Intern Med. 1999 159(16):1865-70.

Fuchs CS, Stampfer MJ, Colditz GA, Giovannucci EL, Manson JE, Kawachi I, et al. Alcohol consumption and mortality among women.N Engl J Med. 1995 332(19):1245-50.

Mukamal KJ, Jensen MK, Grønbaek M, Stampfer MJ, Manson JE, Pischon T, et al. Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. Circulation. 2005 112(10):1406-13.

Bianchini F, Vainio H. Wine and resveratrol: Mechanisms of cancer prevention?.Eur. J. Cancer Prev. 2003 12:417–425.

Schoonen WM, Salinas CA, Kiemeney LA, Stanford JL. Alcohol consumption and risk of prostate cancer in middle-aged men. Int. J. Cancer. 2005 113:133–140.

Chao C. Associations between beer, wine, and liquor consumption and lung cancer risk: A meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2007 16:2436–2447.

Han X, Zheng T, Foss FM, Ma S, Holford TR, Boyle P, et al. Alcohol consumption and non-Hodgkin lymphoma survival. Journal of cancer survivorship : research and practice. 20094(2):101–109.

Battaglioli T, Gorini G, Costantini AS, Crosignani P, Miligi L, Nanni O, et al. Cigarette smoking and alcohol consumption as determinants of survival in non-Hodgkin’s lymphoma: a population-based study. Ann Oncol. 2006 17:1283–1289.

Anderson LA, Cantwell MM, Watson RG, Johnston BT, Murphy SJ, Ferguson HR, et al. The association between alcohol and reflux esophagitis, barrett's esophagus, and esophageal adenocarcinoma. Gastroenterology. 2009 136:799–805.

Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellon EA. Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. J. Androl. 2007 28:282–293.

Zamora-Ros R, Urpi-Sarda M, Lamuela-Raventos RM, Estruch R, Vazquez-Agell M, Serrano-Martinez M, et al. Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin. Chem. 2006 52:1373–1380.

Allen NE, Beral V, Casabonne D, Kan SW, Reeves GK, Brown A, et al. Million Women Study Collaborators. Moderate alcohol intake and cancer incidence in women. J. Natl. Cancer Inst. 2009 101:296–305.

Seitz HK, Pelucchi C, Bagnardi V, La Vecchia C. Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012. Alcohol Alcohol. 2012 47:204–212.

McCarty CA, Reding DJ, Commins J, Williams C, Yeager M, Burmester JK, et al. Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial. Breast Cancer Res. Treat. 2012 133:785–792.

Xia X, Sun B, Li W, Zhang X, Zhao Y. Anti-diabetic activity phenolic constituents from red wine against α-glucosidase and α-amylase. J. Food Process. Preserv. 2016 41(3):e12942.

Qi D, Young LH. AMPK: energy sensor and survival mechanism in the ischemic heart. Trends in endocrinology and metabolism: TEM.201526(8):422–429.

Kurimoto Y,Shibayama Y, Inoue S, Soga M, Takikawa M, Ito C, et al. Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of amp-activated protein kinase in diabetic mice. J. Agric. Food. Chem. 2013 61:5558–5564.

Gitler AD, Dhillon P, Shorter J. Neurodegenerative disease: models, mechanisms, and a new hope. Disease models & mechanisms. 201710(5):499–502.

Silva R, Pogačnik L. Food, polyphenols and neuroprotection. Neural regeneration research. 201712(4):582–583.

Yang F, Wolk A, Håkansson N, Pedersen NL, Wirdefeldt K. Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts. Movement disorders : official journal of the Movement Disorder Society. 201732(11):1631–1636.

Caruana M, Cauchi R, Vassallo N. Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease. Frontiers in nutrition. 20163:31.

Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochimica et BiophysicaActa (BBA)-Molecular Basis of Disease. 20151852(6):1195-1201.

Ma T, Tan MS, Yu JT, Tan L. Resveratrol as a therapeutic agent for Alzheimer's disease. BioMed research international.20142014:350516.

Basli A, Soulet S, Chaher N, Mérillon JM, Chibane M, Monti JP, et al. Wine polyphenols: potential agents in neuroprotection. Oxidative medicine and cellular longevity. 20122012:805762.

O'Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO reports. 20067(7):688–693.

Cresci GA, Bawden E. Gut Microbiome: What We Do and Don't Know. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2015 30(6):734–746.

Etxeberria U, Fernández-Quintela A, Milagro FI, Aguirre L, Martínez JA, Portillo MP. Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition. Journal of agricultural and food chemistry. 201361(40):9517-9533.

Cueva C, Gil-Sánchez I, Ayuda-Durán B, González-Manzano S, González-Paramás AM, Santos-Buelga C, et al. An Integrated View of the Effects of Wine Polyphenols and Their Relevant Metabolites on Gut and Host Health. Molecules. 2017 22(1):99.

Duda-Chodak A. The inhibitory effect of polyphenols on human gut microbiota. J PhysiolPharmacol. 201263(5):497-503.

Marín L, Miguélez EM, Villar CJ, Lombó F. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. BioMed research international. 20152015:905215.

Gibson GR, Fuller R. Aspects of in vitro and in vivo research approaches directed toward identifying probiotics and prebiotics for human use. The Journal of nutrition. 2000 130(2):391S-395S.

Dueñas M, Cueva C, Muñoz-González I, Jiménez-Girón A, Sánchez-Patán F, Santos-Buelga C, et al. Studies on Modulation of Gut Microbiota by Wine Polyphenols: From Isolated Cultures to Omic Approaches. Antioxidants. 2015 4(1):1–21.

Queipo-Ortuño MI, Boto-Ordóñez M, Murri M, Gomez-Zumaquero JM, Clemente-Postigo M, Estruch R, et al. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. The American journal of clinical nutrition. 2012 95(6):1323-1334.

Tzounis X, Vulevic J, Kuhnle GG, George T, Leonczak J, Gibson GR, et al. Flavanol monomer-induced changes to the human faecal microflora. British Journal of Nutrition.2008 99(4):782-792.

Barroso E, Muñoz‐González I, Jiménez E, Bartolome B, Moreno‐Arribas MV, Pelaez C, et al. Phylogenetic profile of gut microbiota in healthy adults after moderate intake of red wine. Molecular nutrition & food research. 201761(3):1600620.



  • There are currently no refbacks.

Copyright (c) 2019 © The Authors

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski