Complex pathogenetic treatment of liver cirrhosis

O. F. Dzygal, R. S. Vastyanov


Treatment of patients with liver cirrhosis (LC) and its complications is one of the most difficult problems of surgery, in particular, surgical hepatology and biliary surgery. According to WHO data, the frequency of LC is steadily increasing. According to these data the authors conclude that there is a lack of understanding of pathogenetic mechanisms liver parenchymatic cells cirrhotic lesion.
Chronic experimental trials were carried out to reproduce the model of LC in rats by four-carbon monoxide peroral administration. In the rat blood 1, 6, 12 hours, 1, 3, 5 and 7 days after the experimental LC formation, proteolysis standard activity was determined through lysosomal enzymes activity measurement.
It was found that LC manifestation is accompanied by activation in blood serum of rats of acid, trypsin-like proteases and lysosomal enzymes, indicating the generalization of the process. Catepsin D activation indicates the presence of inflammatory-destructive changes in the liver which reflects systemic inflammation in case of LC. The data obtained suggest that rats blood proteolysis activation is probably one of the components of pathogenesis of the disease,
Both alpha-lipoic acid and tivortine positive effects are the experimental background of their clinical testing reasonability in patients with LC, both individually and in combination with hepatoprotective compounds.


experimental cirrhosis of the liver, pathogenetic mechanisms, proteolysis, alpha lipoic acid, tivortin, complex treatment

Full Text:



Yeramishantsev АК, Manuk’yan GV "Today" and "tomorrow" of portal hypertension surgery: a view at the problem. Clin. Problems Gastroenterol. 2001;5:20–6 [In Russian].

Mansurov HH. Portal hypertension: pathophysiology, clinic, diagnosis and management of patients. Rus. J. Gastroenterol. Hepatol. Coloproctol.. 1997;3:63–72 [In Russian].

Severtcev N Portal hypertension. Clin. Herald. 1997;3:35–9 [In Russian].

de Franchis R. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertensionю J Hepatol. 2015;63:743–52.

García–Pagán JC, Gracia–Sancho J, Bosch J. Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatol. 2012;57: 458–61

Wei W, Pu YS, Wang XK, et al. Wall shear stress in portal vein of cirrhotic patients with portal hypertension.World J Gastroenterol. 2017;23(18): 3279–32.

Corrigan M. Aspects of the Pathophysiology of Primary Biliary Cirrhosis / M. Corrigan, G.M. Hirschfield // Dig. Dis. – 2015. – Vol. 33, Suppl. 2. – S. 102-108.

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis / Fucho R., Martínez L., Baulies A. et al. // J. Hepatol. – 2014. – Vol. 61, N 5. – P. 1126-1134.

Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway / Müller C., Dünschede F., Koch E. et al. // Am. J. Physiol. Gastrointest. Liver Physiol. – 2003. – Vol. 285, N 4. – P. 769-778.

Bao X.Q. Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine / Bao X.Q., Liu G.T. // J. Asian Nat. Prod. Res. – 2010. – Vol. 12, N 4. – P. 313-323.

Galperin EI Liver cirrhosis and ascites induction in the experiment. Exp. Surg. 1960; (1): 46-4 [In Russian].

Veremeenko KN Proteolytic enzymes and their inhibitors in clinical practice / КN Veremeenko. –Кiev : Zdorov’ya, 1971. - 215 p. [In Russian].

Role of nitric oxide in kidney and liver (as distance organ) function in bilateral renal ischemia-reperfusion: Effect of L-Arginine and NG-nitro-L-Arginine methyl ester / Ghasemi M., Nematbakhsh M., Daneshmand F. et al. // Adv. Biomed. Res. 2015. 4: 233. doi: 10.4103/2277-9175.167954



  • There are currently no refbacks.

Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski