Secreted Frizzled-Related Protein 5 in Serum and Urine of Post-Partum Women with Gestational Diabetes Mellitus

Marcin Trojnar, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak

Abstract


Secreted frizzled-related protein 5 (SFRP5) is a newly identified member of the SFRP family produced by the adipose tissue which can act as an anti-inflammatory adipokine. The aim of the study was to assess SFRP5 levels in the serum and urine of women with gestational diabetes mellitus (GDM) in the early post-partum period with reference to their laboratory test results, body composition and hydration status.
The study subjects included two groups: 22 GDM patients and 24 healthy controls. Maternal body composition and hydration status were evaluated by the bioelectrical impedance analysis (BIA) method. The serum and urine SFRP5, leptin and ghrelin concentrations were determined via enzyme-linked immunosorbent assay (ELISA).
No significant differences were observed between the GDM and healthy groups with regard to the serum and urine SFRP5 concentrations. In the GDM group serum and urine SFRP5 levels correlated positively. The serum SFRP5 concentrations correlated negatively with hemoglobin A1c (HgbA1c) and leptin serum levels in the controls. In the control and GDM groups the serum and urine SFRP5 levels correlated negatively with the serum ghrelin levels.
It appears that ghrelin as well as SFRP5 could influence the metabolic homeostasis 48 hours after delivery.
A significant correlation between concentrations of SFRP5 in the serum and urine seems to suggest that urine sampling may represent an alternative to the current standard of management i.e. blood sampling. Further research in this field is required.

Keywords


adipokines; secreted frizzled-related protein 5; leptin; gestational diabetes mellitus; bioelectrical impedance analysis; body composition; hydration status

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References


Rodrigo N.; Glastras S.J. The Emerging Role of Biomarkers in the Diagnosis of Gestational Diabetes Mellitus. J. Clin. Med. 2018; 7: pii: E120.

Kimber-Trojnar Ż.; Patro-Małysza J.; Skórzyńska-Dziduszko K.E.; Oleszczuk J.; Trojnar M.; Mierzyński R.; et al. Ghrelin in Serum and Urine of Post-Partum Women with Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2018; 19: pii: E3001.

Marciniak A.; Patro-Małysza J.; Kimber-Trojnar Ż.; Marciniak B.; Oleszczuk J.; Leszczyńska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan. J. Obstet. Gynecol. 2017; 56: 133–138.

Bellamy L.; Casas J.; Hingorani A.; Williams D. Type 2 diabetes mellitus after gestational diabetes: A systematic review and meta-analysis. Lancet 2009; 373: 1773–1779.

Neiger R. Long-Term Effects of Pregnancy Complications on Maternal Health: A. Review. J. Clin. Med. 2017; 6: 76.

Oh K.J.; Lee D.S.; Kim W.K.; Han B.S.; Lee S.C.; Bae K.H. Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. Int. J. Mol. Sci. 2016; 18: pii: E8.

Hu Z.; Deng H.; Qu H. Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance. Diabetes Res. Clin. Pract. 2013; 99: 391-395.

Hu W.; Li L.; Yang M.; Luo X.; Ran W.; Liu D.; et al. Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans. J. Clin. Endocrinol. Metab. 2013; 98: 290-298.

Xu Q.; Wang H.; Li Y.; Wang J.; Lai Y.; Gao L.; et al. Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults. Diabetes Metab. Res. Rev. 2017; 33.

Carstensen M.; Herder C.; Kempf K.; Erlund I.; Martin S.; Koenig W.; et al. Sfrp5 correlates with insulin resistance and oxidative stress. Eur. J. Clin. Invest. 2013; 43: 350-357.

Teliewubai J.; Bai B.; Zhou Y.; Lu Y.; Yu S.; Chi C.; et al. Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study. Clin. Interv. Aging 2018; 13: 389-395.

Liu L.B.; Chen X.D.; Zhou X.Y.; Zhu Q. The Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus. Biosci. Rep. 2018; 38: pii: BSR20180011.

Chang J.T.; Esumi N.; Moore K.; Li Y.; Zhang S.; Chew C.; et al. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Hum. Mol. Genet. 1999; 8: 575-583.

You J.; Hodge C.; Wen L.; McAvoy J.W.; Madigan M.C.; Sutton G. Tear levels of SFRP1 are significantly reduced in keratoconus patients. Mol. Vis. 2013; 19: 509-515.

García-Tobilla P.; Solórzano S.R.; Salido-Guadarrama I.; González-Covarrubias V.; Morales-Montor G.; Díaz-Otañez C.E.; et al. SFRP1 repression in prostate cancer is triggered by two different epigenetic mechanisms. Gene 2016; 593: 292-301.

Wang Ch. Obesity, inflammation, and lung injury (OILI): the good. Mediators Inflamm. 2014; 2014: ID 978463.

Gutiérrez-Vidal R.; Vega-Badillo J.; Reyes-Fermín L.M.; Hernández-Pérez H.A.; Sánchez-Muñoz F.; López-Álvarez G.S.; et al. SFRP5 hepatic expression is associated with non-alcoholic liver disease in morbidly obese women. Ann. Hepatol. 2015; 14: 666-674.

Serizawa R.R.; Ralfkiaer U.; Steven K., Lam G.W.; Schmiedel S.; Schüz J.; et al. Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events. Int. J. Cancer 2011; 129: 78-87.

Urakami S.; Shiina H.; Enokida H.; Kawakami T.; Kawamoto K.; Hirata H.; et al. Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin. Cancer Res. 2006; 12: 2109-2116.

International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010; 33: 676–682.

Diabetes Poland (Polish Diabetes Association). 2018 Guidelines on the management of diabetic patients. A position of Diabetes Poland. Clin. Diabetol. 2018; 7: 1–90.

Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines; Rasmussen, K.M.; Yaktine, A.L. Weight Gain during Pregnancy: Reexamining the Guidelines; National Academies Press, Washington (DC), WA, USA, 2009.

Oztas E.; Ozler S.; Ersoy E.; Ersoy A.O.; Tokmak A.; Ergin M.; et al. Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels. J. Matern. Fetal Neonatal Med. 2016; 29: 1515-1519.

Almario R.U.; Karakas S.E. Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Horm. Metab Res. 2015; 47: 152-157.

Wang C.P.; Yu T.H.; Wu C.C.; Hung W.C.; Hsu C.C.; Tsai I.T.; et al. Circulating secreted frizzled-related protein 5 and chronic kidney disease in patients with acute ST-segment elevation myocardial infarction. Cytokine 2018; 110: 367-373.

Fasshauer M.; Blüher M.; Stumvoll M. Adipokines in gestational diabetes. Lancet Diabetes Endocrinol. 2014; 2: 488–499.

Soheilykhah S.; Mojibian M.; Rahimi-Saghand S.; Rashidi M.; Hadinedoushan H. Maternal serum leptin concentration in gestational diabetes. Taiwan. J. Obstet. Gynecol. 2011; 50: 149-153.

Toan N.L.; Van Hoan N.; Cuong D.V.; Dung N.V.; Dung P.T.; Hang N.T.; et al. Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus. Diabetol. Metab. Syndr. 2018; 10: 41.

Li B.; Yao Q.; Guo S.; Ma S.; Dong Y.; Xin H.; et al. Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5. Clin. Exp. Hypertens. 2018; 1-6.

Knights A.J.; Funnell A.P.; Pearson R.C.; Crossley M.; Bell-Anderson K.S. Adipokines and insulin action: A sensitive issue. Adipocyte 2014; 3: 88-96.

Uslu S.; Kebapçi N.; Kara M.; Bal C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Exp. Ther. Med. 2012; 4: 113-120.

Colomiere M.; Permezel M.; Lappas M. Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue. J. Mol. Endocrinol. 2010; 44: 213-223.

Li W.; Zhang S.; Liu H.; Wang L.; Zhang C.; Leng J.; et al. Different associations of diabetes with β-cell dysfunction and insulin resistance among obese and nonobese Chinese women with prior gestational diabetes mellitus. Diabetes Care 2014; 37: 2533-2539.

Ozkorucu D.; Cetin N.; Sav N.M.; Yildiz B. Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome. Int. Urol. Nephrol. 2016; 48: 1187–1196.

Li Y.Y.; Xiao R.; Li C.P.; Huangfu J.; Mao J.F. Increased plasma levels of FABP4 and PTEN is associated with more severe insulin resistance in women with gestational diabetes mellitus. Med. Sci. Monit. 2015; 21: 426–431.

Dubé E.; Gravel A.; Martin C.; Desparois G.; Moussa I.; Ethier-Chiasson M.; et al. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. Biol. Reprod. 2012; 87: 1-11.

Huopio H.; Hakkarainen H.; Pääkkönen M.; Kuulasmaa T.; Voutilainen R.; Heinonen S.; et al. Long-Term changes in glucose metabolism after gestational diabetes: A double cohort study. BMC Pregnancy Childbirth 2014; 14: 296.

Viteri O.A.; Sallman M.A.; Berens P.M.; Berens P.D.; Amro F.H.; Hutchinson M.S.; et al. Potential of Metformin to Improve Cardiac Risk in Postpartum Women with Gestational Diabetes. Front. Med. 2017; 4: 180.

Kovacevic L.; Lu H.; Caruso J.A.; Govil-Dalela T.; Thomas R.; Lakshmanan Y. Marked increase in urinary excretion of apolipoproteins in children with nephrolithiasis associated with hypercalciuria. Pediatr. Nephrol. 2017; 32: 1029-1033.

Ghezzi F.; Franchi M.; Balestreri D.; Lischetti B.; Mele M.C.; Alberico S.; et al. Bioelectrical impedance analysis during pregnancy and neonatal birth weight. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001; 98: 171–176.

Ridner S.H.; Dietrich M.S.; Deng J.; Bonner C.M.; Kidd N. Bioelectrical impedance for detecting upper limb lymphedema in nonlaboratory settings. Lymphat. Res. Biol. 2009; 7: 11–15.

Shaikh S.; Schulze K.J.; Ali H.; Labrique A.B.; Shamim A.A.; Rashid M.; et al. Bioelectrical impedance among rural Bangladeshi Women during pregnancy and in the postpartum period. J. Health Popul. Nutr. 2011; 29: 236–244.

Lukaski H.C.; Johnson P.E.; Bolonchuk W.W.; Lykken G.I. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am. J. Clin. Nutr. 1985; 41: 810–817.

Wang Y.; Mao J.; Wang W.; Qiou J.; Yang L.; Chen S. Maternal fat free mass during pregnancy is associated with birth weight. Reprod. Health 2017; 14: 47.




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