Vitamin D deficiency and tension-type headaches in children - literature review

Grzegorz Zieliński, Michał Ginszt, Zuzanna Filipiak, Marta Suwała, Piotr Majcher


Tension-type headache (TTH) is perceived as bilateral pressure, tension or non-pulsatile mild to moderate headache. The etiopathogenesis of the occurrence of this phenomenon among children has been extrapolated from adult studies. The purpose of this review was to show the association between tension-type headaches and vitamin D deficiency in children based on available literature.
Materials and methods
Systematic review based on the content of PubMed, ResearchGate, and Google Scholar databases was performed. In order to identify relevant publications, a search was performed using a combination of key words: "children", "tension-type headache", "vitamin D", "25 (OH) D". Three studies have been included in our review.
Considering the value of the evidence and the results in peer-reviewed publications, we conclude that there is too little evidence to support the hypothesis that there is a connection between tension-type pains and vitamin D deficiency in children.
Due to the small amount of available literature, research on the effects of vitamin D deficiency on tension-type headaches in children should be continued on a larger scale. Based on the above analysis, we find that there is too little evidence to support the hypothesis that the level of vitamin D affects the development of tension-type headaches in children.


children; tension headaches; vitamin D; 25 (OH) D

Full Text:



Ashina S, Bendtsen L, Ashina M. Pathophysiology of tension-type headache. Curr Pain Headache Rep 2005; 9: 415–422.

Olesen J. The international classification of headache disorders. 2nd edition (ICHD-II). Rev Neurol (Paris) 2005; 161: 689–691.

Waś A, Tucholska S. Napięciowe bóle głowy – aspekty psychologiczne. Neurol Dziecięca 2011; 20: 115–119.

Monteith TS, Sprenger T. Tension Type Headache in Adolescence and Childhood: Where Are We Now? Curr Pain Headache Rep 2010; 14: 424–430.

Aegidius KL, Zwart J-A, Hagen K, et al. Increased headache prevalence in female adolescents and adult women with early menarche. The Head-HUNT Studies. Eur J Neurol 2011; 18: 321–328.

Ozge A, Sasmaz T, Cakmak SE, et al. Epidemiological-based childhood headache natural history study: after an interval of six years. Cephalalgia Int J Headache 2010; 30: 703–712.

Nicholson RA, Houle TT, Rhudy JL, et al. Psychological Risk Factors in Headache. Headache 2007; 47: 413–426.

Straube S, Andrew Moore R, Derry S, et al. Vitamin D and chronic pain. Pain 2009; 141: 10–13.

Prakash S, Rathore C, Makwana P, et al. Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study. Headache 2017; 57: 1096–1108.

Martin KR, Reid DM. Is there a role for vitamin D in the treatment of chronic pain? Ther Adv Musculoskelet Dis 2017; 9: 131–135.

Prakash S, Shah ND. Chronic Tension-Type Headache With Vitamin D Deficiency: Casual or Causal Association? Headache J Head Face Pain 2009; 49: 1214–1222.

Donmez A, Orun E, Sonmez FM. Vitamin D status in children with headache: A case-control study. Clin Nutr ESPEN 2018; 23: 222–227.

Sonmez FM, Donmez A, Namuslu M, et al. OP30 – 2317: Vitamin D status in children with headache: A case-control study. Eur J Paediatr Neurol 2015; 19: S10.

Tozzi E, Aless, Boncristiano R, et al. Vitamin D [25(OH)D] Serum Level on Headache Children. J Headache Pain Manag; 1. Epub ahead of print 27 May 2016. DOI: 10.4172/2472-1913.100017.

Prakash S, Rathore C, Makwana P, et al. Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study. Headache 2017; 57: 1096–1108.

Prakash S, Kumar M, Belani P, et al. Interrelationships between chronic tension-type headache, musculoskeletal pain, and vitamin D deficiency: Is osteomalacia responsible for both headache and musculoskeletal pain? Ann Indian Acad Neurol 2013; 16: 650–658.

Reginato AJ, Coquia JA. Musculoskeletal manifestations of osteomalacia and rickets. Best Pract Res Clin Rheumatol 2003; 17: 1063–1080.

Yorifuji J, Yorifuji T, Tachibana K, et al. Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency. J Clin Endocrinol Metab 2008; 93: 1784–1788.

Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 2002; 13: 187–194.

Fernández-de-las-Peñas C, Cuadrado ML, Arendt-Nielsen L, et al. Myofascial trigger points and sensitization: an updated pain model for tension-type headache. Cephalalgia Int J Headache 2007; 27: 383–393.

Cayir A, Turan MI, Tan H. Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients. Braz J Med Biol Res Rev Bras Pesqui Medicas E Biol 2014; 47: 349–354.



  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski