The therapeutic effect of antidisbiotic means on the mucous sheath of rats digestive tract, obtaining peroxidized sunflower oil

A. P. Levitsky, A. I. Gozhenko, A. V. Bocharov, G. Z. Boris, P. I. Pustovoit, G. N. Varava

Abstract


Aim: Determine the therapeutic effect of antidysbiosis agents (ADA) on the condition of the mucous membrane of the digestive tract when consumed per-oxidized sunflower oil (PSO).
Materials and Methods: Rats were fed 4 g / kg of PSO for 75 days. From the 31st day, they were administered one of the following ADA with 300 mg / kg of food: kvertulin (quercetin + inulin + calcium citrate), lekvin (lecithin + kvertulin) and lysozyme-forte (lysozyme + quercetin + inulin + gelatin + calcium citrate). The activity of elastase, urease, lysozyme, catalase and the content of MDA were determined in the homogenates of the mucous cheeks, small and large intestine. The ratio of catalase activity and the content of MDA was calculated by the API index, and the ratio of the relative activities of urease and lysozyme - the degree of dysbiosis.
Results: The consumption of PSO in rats in the mucous membranes of the digestive tract increases the activity of elastase, urease, MDA content and the degree of dysbiosis while reducing the activity of lysozyme, catalase and the API index. In rats treated with ADA, the activity of elastase, urease, MDA content, and the degree of dysbiosis decrease, but the activity of lysozyme and catalase increase.
Conclusion: Peroxide intoxication causes the development of mucositis, which can be prevented by antidysbiosis agents.

Keywords


lipid peroxides, digestive system, mucositis, dysbiosis, anti- dysbiosis agents

Full Text:

PDF

References


Furdychko A. I., Skidan M. I., Levitsky A. P. The influence of antidysbiotic preparations upon the state of periodontium in rats with the experimental nonalcoholic steatohepatitis. Visnyk stomatologii'. 2016; 1(94): 5-10.

Furdychko A. I. The influence of hepatoprotector with Silybum marianum and lecithin upon the state of periodontium in rats with toxic hepatitis. Visnyk stomatologii'. 2016; 9: 19-23.

Levitsky AP, Makarenko OA, Pochtar' VN et al. Perekisnaja model' stomatita [The peroxide model of stomatitis]. Visnyk stomatologii', 2005;4:7–10.

Levitsky A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Kvertulin. Vitamin P, prebiotik, gepatoprotektor [“Querthulin”, Vitamin P, prebiotic, hepatoprotector]. Оdеssа, KP OGT, 2012: 20.

TU U 10.8-37420386-003:2016 «Dietary «Lekvin». Vysnovok MOZU № 05.03.02-06/8400 vid 21.03.2016.

TU U 10.8-37420386-004:2016 «Dietary «Lizocym-forte». Vysnovok MOZU № 602-123-20-2/5734 vid 22.12.2016.

Levitsky A. P., Stefanov A. V. Metody opredeleniya aktivnosti elastazy i eye ingibitorov: metodicheskie rekomendatsii [The methods of the determination of the activity of elastase and its inhibitors: method guidelines]. Kiev, GFK, 2002:15.

Gavrikova L. M., Segen I. T. Urease activity of oral liquid in patients with acute odontogenic infection of maxillo-facial part. Stomatologiya. 1996; The extra issue: 49-50.

Levitsky A. P. Lizotsym vmesto antibiotikov [Lysozyme instead of antibiotics]. Оdеssа, KP OGT, 2005: 74.

Girin S. V. The modification of the method of the determination of catalase activity in biological substrates. Laboratornaya diagnostika. 1999; 4:45-46.

Stalnaya I. D., Garishvili T. G. Metod opredeleniya malonovogo dialdegida s pomoshchyu tiobarbiturovoy kisloty [The method of revelation of malonic dialdehyde with thiobarbituric acid]. Moskva, Meditsina, 1977: 66-68.

Levitsky A. P., Denga O. V., Makarenko O. A. [et al.]. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti: metodicheskie rekomendatsii [Biochemical markers of inflammation of oral cavity tissue: method guidelines]. Оdеssа, KP OGT, 2010:16.

Truhacheva N. V. Matematicheskaja statistika v mediko-biologicheskih issledovanijah s primeneniem paketa Statistica [Mathematical Statistics in biomedical research using application package Statistica]. Moskva, GJeOTAR-Media, 2012: 379.




DOI: http://dx.doi.org/10.5281/zenodo.2589464

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)