SFRP5-leptin ratio as a promising index in post-partum women with gestational diabetes mellitus

Żaneta Kimber-Trojnar, Jolanta Patro-Małysza, Bożena Leszczyńska-Gorzelak

Abstract


INTRODUCTION: Gestational diabetes mellitus (GDM) has often been referred to as the “marker” for the development of diabetes, obesity and cardiovascular diseases in future lives of women. In the current literature the adiponectin-leptin ratio is presented as a valuable index to estimate adipose tissue dysfunction.
OBJECTIVES: The aim of the study was to investigate the significance of a novel parameter, i.e. the ratio of serum concentration of secreted frizzled-related protein 5 (SFRP5) to that of leptin in the early post-partum period. The associations between SFRP5/leptin ratio and maternal laboratory test results, body composition and hydration status were also assessed.
PATIENTS AND METHODS: 26 mothers diagnosed with gestational diabetes mellitus (GDM) and 28 healthy controls were enrolled in the study. Body composition and hydration status of the patients were evaluated with the use of bioelectrical impedance analysis (BIA) method. The serum concentrations of SFRP5, leptin, fatty acid-binding protein 4 (FABP4) and ghrelin were determined via enzyme-linked immunosorbent assay (ELISA).
RESULTS: SFRP5/leptin ratio was lower in the GDM mothers in comparison to that of the control group. There were positive correlations between SFRP5/leptin ratio and total cholesterol and low-density lipoprotein cholesterol (LDL) levels. The SFRP5/leptin ratio correlated negatively with total body water (TBW) and extracellular water (ECW).
CONCLUSIONS: The SFRP5/leptin ratio appears to be a promising index for evaluating of metabolic disturbances in mothers with a history of GDM.

Keywords


adipokines; secreted frizzled-related protein 5; leptin, bioelectrical impedance analysis; gestational diabetes mellitus

Full Text:

PDF

References


Ambroszkiewicz J., Chełchowska M., Rowicka G., et al. Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets. Nutrients 2018; 10: pii: E1241.

Bluher M., Rudich A., Kloting N., et al. Two patterns of adipokine and other biomarkers dynamics in a long-term weight loss intervention. Diabetes Care 2012; 35: 342–349.

Gateva A., Assyov Y., Tsakova A., Kamenov Z. Classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokines in patients with prediabetes. Horm. Mol. Biol. Clin. Investig. 2018; 34.

You J., Hodge C., Wen L., et al. Tear levels of SFRP1 are significantly reduced in keratoconus patients. Mol Vis. 2013; 19: 509-515.

García-Tobilla P., Solórzano S.R., Salido-Guadarrama I., et al. SFRP1 repression in prostate cancer is triggered by two different epigenetic mechanisms. Gene. 2016; 593: 292-301.

Schulte D.M., Müller N., Neumann K., et al. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. PLoS One. 2012; 7: e32437.

Liu L.B., Chen X.D., Zhou X.Y., Zhu Q. The Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus. Biosci Rep. 2018; 38: pii: BSR20180011.

Oztas E., Ozler S., Ersoy E., et al. Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels. J Matern Fetal Neonatal Med. 2016; 29: 1515-1519.

Kimber-Trojnar Ż., Patro-Małysza J., Trojnar M., et al. Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain. Int J Mol Sci. 2019; 20: pii: E595.

Frühbeck G., Catalán V., Rodríguez A., et al. Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation. Nutrients. 2019; 11: pii: E454.

Kimber-Trojnar Ż., Patro-Małysza J., Skórzyńska-Dziduszko K.E., et al. Ghrelin in Serum and Urine of Post-Partum Women with Gestational Diabetes Mellitus. Int J Mol Sci. 2018; 19: pii: E3001.

Patro-Małysza J., Trojnar M., Kimber-Trojnar Ż., et al. FABP4 in Gestational Diabetes—Association between Mothers and Offspring. J. Clin. Med. 2019; 8: 285.

Varner M.W., Rice M.M., Landon M.B., et al. Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. Obstet Gynecol 2017; 129: 273.

Bellamy L., Casas J.P., Hingorani A.D., Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009; 373: 1773

Feig D.S., Zinman B., Wang X., Hux J.E. Risk of development of diabetes mellitus after diagnosis of gestational diabetes. CMAJ 2008; 179: 229.

Oh K.J., Lee D.S., Kim W.K., et al. Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. Int J Mol Sci. 2016; 18: pii: E8.

Hu W., Li L., Yang M., et al. Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans. J Clin Endocrinol Metab. 2013; 98: 290-298.

Xu Q., Wang H., Li Y., et al. Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults. Diabetes Metab Res Rev. 2017; 33.

Carstensen M., Herder C., Kempf K., et al. Sfrp5 correlates with insulin resistance and oxidative stress. Eur J Clin Invest. 2013; 43: 350-357.

Teliewubai J., Bai B., Zhou Y., et al. Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study. Clin Interv Aging. 2018; 13: 389-395.

Ouchi N., Higuchi A., Ohashi K., et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science. 2010; 329: 454-457.

Fasshauer M., Blüher M., Stumvoll M. Adipokines in gestational diabetes. Lancet Diabetes Endocrinol. 2014; 2: 488–499.

Tan X., Wang X., Chu H., et al. SFRP5 correlates with obesity and metabolic syndrome and increases after weight loss in children. Clin Endocrinol (Oxf). 2014; 81: 363-369.

Li B., Yao Q., Guo S., et al. Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5. Clin Exp Hypertens. 2018: 1-6.

Uslu S., Kebapçi N., Kara M., Bal C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Exp Ther Med. 2012; 4: 113-120.

Ridner S.H., Dietrich M.S., Deng J., et al. Bioelectrical impedance for detecting upper limb lymphedema in nonlaboratory settings. Lymphat Res Biol. 2009; 7: 11–15.

Shaikh S., Schulze K.J., Ali H., et al. Bioelectrical impedance among rural Bangladeshi Women during pregnancy and in the postpartum period. J Health Popul Nutr. 2011; 29: 236–244.

Wang Y., Mao J., Wang W., et al. Maternal fat free mass during pregnancy is associated with birth weight. Reprod Health. 2017; 14: 47.




DOI: http://dx.doi.org/10.5281/zenodo.2583748

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)