Possibility of therapy of acute ischemic stroke by polyphenols of flavonoid group

V. V. Dobrovolskyi, O. M. Stoyanov, S. S. Mashchenko

Abstract


Objective - to study neuroprotective effect of Quercetin in ischemia-reperfusion injury in acute ischemic stroke.
Materials and methods. The study included 98 patients with acute ischemic stroke. All patients: main and control group, received standard treatment in accordance with the clinical protocol order Ministry of Health of Ukraine from 03.08.2012, № 602. Patients of the main group (n=68) on the back of the base further treatment was administered quercetin (Corvitin lyophilisate injection solution) course of 10 days according to the scheme: 500 mg of the drug diluted in 100 ml of 0.9% of the physiological solution intravenously twice a day for the first five days and once a day for the next five days. Patients in the control group (n=30) - quercetin is not appointed. Assessment by GCS, NIHSS, Barthel served in the 1st, 3rd, 5th, 10th day of the disease.
Results. Simultaneously with the standard treatment, intravenous administration of quercetin, positively influenced the regression of focal neurological symptoms on the NIHSS and Barthel scales in patients with acute ischemic stroke, increased the proportion of patients in the consciousness or with its minor impairments in the GCS, ie contributed to an earlier “awakening” in acute ischemic stroke.
Conclusions. Neuroprotective effect of quercetin (Corvitin lyophilisate injection solution) can be explained by its polytropic, antioxidant, anti-inflammatory, membrane-stabilizing effect in ischemia-reperfusion.

Keywords


stroke, reperfusion injury, quercetin

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DOI: http://dx.doi.org/10.5281/zenodo.2579346

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