Have thyroid hormones an impact on ovarian cancer?

Klaudia Żak, Sylwiusz Niedobylski, Milena Leziak, Karolina Maliszewska, Mirella Czapska, Katarzyna Skórzyńska-Dziduszko


Thyroid hormones show not only genomic, but also nongenomic activity, which is related to specific membrane, cytoplasmic and organelle receptors. The best known receptors are located on the alpha-V-beta-3 integrin of cell membrane. Their stimulation results in an activation of mitogen-activated protein kinases (MAPKs) or phosphoinositide 3-kinase (PI3K), which directly leads to an inhibition of apoptosis and increased proliferation of tumor cells, as well as promotes angiogenesis and metastasis formation. In ovarian cancer cells L-thyroxine is proven to be involved in MAPK activation as well as in the up-regulation of expression and enhanced cellular accumulation of programmed death ligand 1 (PD-L1), which results in an inhibition of neoplastic cells apoptosis.


thyroid hormones; ovarian cancer.

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DOI: http://dx.doi.org/10.5281/zenodo.2537850


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