Tissue inhibitor of matrix metalloproteinase-1 role in left atrium matrix remodeling in patients with atrial febrillation

A. V. Goryachiy, A. I. Gozhenko, E. M. Levchenko, V. V. Goryachiy, M. A. Kuznetsova, M. I. Arapu

Abstract


Method: TIMP-1 was used as a marker for collagen synthesis. The study group comprised 69 people and the control group 23.
Results: Patients with persistent and chronic AF had an elevated level of TIMP-1 in comparison with patients with paroxysmal AF (149.63 + 43.71 ng / ml, 155.90 + 45.86 ng / ml vs 131.51 + 36.92 ng / ml, p <0.001). The level of TIMP-1 was significantly lower in the control group compared to patients with paroxysmal, persistent and chronic AF forms (131.51 + 36.92 ng / ml, 149.63 + 43.71 ng / ml, 155.90 + 45.86 ng / ml and 103.61 + 14.96 ng / ml , P <0.001).
Conclusions: The level of TIMP-1 is significantly different between healthy people and patients with AF. Moreover, these markers also differ depending on the shape of the OP. It can be assumed that the intensity of extracellular synthesis and degradation of type I collagen can be related to the severity and type of AF.

Keywords


atrial fibrillation, cardiovascular diseases, tissue inhibitor, matrix metalloproteinase

Full Text:

PDF

References


Regular physical activity and risk of atrial fibrillation: a systematic review and meta-analysis / P. Ofman, O. Khawaia, C Rahilly-Tierney [et al.] // Circulation. ¬ 2013. ¬ Vol. 6. ¬ P. 252-256.

Rates and implications for hospitalization of patients ≥65 years of age with atrial fibrillation/flutter / G. Naccarelli, S. Johnston, M Dalal [et al.] // Am. J. Cardiol. ¬ 2012. ¬ Vol. 109. ¬ P. 543-549.

Aldhoon B., Melenovský V., Peichl P., Kautzner J. New insights into mechanisms of atrial fi- brillation // Physiol Res. – 2010. – Vol. 59. – No 1. – P. 1–12.

Nguyen B. L, Fishbein MC. Histopathological substrate for chronic atrial fibrillation in humans // Heart Rhythm. – 2009. – 6 (4). – Р. 454–60.

Weber K. T. J Am Coll Cardiol. Cardiac interstitium in health and disease: the fibrillar collagen network // – 2009, Jun. – 13 (7). – Р. 1637–52.


Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 1997;96:1180–4.

Fan D, Takawale A, Lee J, et al. Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair 2012; 5: 15.

Veidal SS, Nielsen MJ, Leeming DJ, et al. Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model. BMC Res Notes 2012; 5: 686.

Lo ́pez B, Gonza ́lez A, Varo N, Laviades C, Querejeta R, D ́ıez J. Biochemical assessment of myocardial fibrosis in hypertensive heart disease. Hypertension 2001;38:1222–6.

Ducharme A, Frantz S, Aikawa M, et al. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest 2000; 106: 55–62.

Z. Hijazi, J. Oldgren, A. Siegbahn, and L. Wallentin Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation Clinical Chemistry 63:1 152–164 (2017)

Lijnen P, Petrov V, Fagard R. Induction of cardiac fibrosis by transforming growth factor-b1. Mol Genet Metab 2000;71:418–35.

Paulus Kirchhof, Stefano Benussi, Dipak Kotecha, Anders Ahlsson, Dan Atar, Barbara Casadei, Manuel Castella, Hans-Christoph, Diener Hein, Heidbuchel Jeroen Hendriks. Eur Heart J (2016) 37 (38): 2893-2962.

Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Miyamoto S, Moriyama M, Ono K. Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh. Circ J. 2016 May 25;80(6):1346-55. doi: 10.1253/circj.CJ-15-1276.

Martin Aguilar, Xiao Yan Qi, Hai Huang, Philippe Comtois, Stanley Nattel1 Fibroblast Electrical Remodeling in Heart Failure and Potential Effects on Atrial Fibrillation Biophysical Journal Volume 107 November 2014 2444–2455

Kato K, Fujimaki T, Yoshida T, et al. Impact of matrix metalloproteinase-2 levels on long-term outcome following pharmacological or electrical cardioversion in patients with atrial fibrillation. Europace 2009; 11: 332–337.

Kostin S, Klein G, Szalay Z, Hein S, Bauer E, Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovasc Res 2002;54:361–79.

Chiang CE, Naditch-Bruˆ le ́ L, Murin J, et al. Distribution and risk profile of paroxysmal, persistent, and permanent atrial fibrillation in routine clinical practice: insight from the real-life global survey evaluating patients with atrial fibrillation international registry. Circ Arrhythm Electrophysiol 2012; 5: 632–639.

Santos MC, de Souza AP, Gerlach RF, et al. Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements. J Oral Rehabil 2004; 31: 660–664.




DOI: http://dx.doi.org/10.5281/zenodo.1472786

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)