Effectiveness of the therapeutic-prophylactic complex in patients with bronchial asthma against the background of excessive body weight or obesity

D. O. Lagoda

Abstract


Nowadays bronchial asthma (BA) is one of the leading problems along with cardiovascular and infectious diseases. The GINA edition of 2017 states that non-rational use of BASD drugs is a risk factor for acute asthma, and their excessive use is a risk factor for premature death from the disease itself. We examined 75 patients with a diagnosis of asthma. By the study design, all patients had EBW or obesity and the mean body mass index (BMI) in the examined patients was 31.76 kg / m2. the patients in the main group on an average lowered the body weight by 4.5 kg, and BMI from 32.00 kg / m2 changed by 29.7 kg / m2 (p˂0.05). We observed a significant decrease in the T- and B-lymphocyte and CIC in patients of the main group (p<0.05), however, 32 weeks after the use of TPC, it was noted that the immunograms returned to the baseline. patients in the main group had significantly better control of asthma than patients in the comparison and control groups (p˂0.05). Also, attention should be attracted to the fact that the given figure shows average values for all severity courses of BA, that is, the group includes patients with mild to moderate and severe course of asthma. Thus, we found that 78% of patients in the main group with mild asthma got control of the disease during treatment and kept it for 32 weeks. After 32 weeks of the follow-up, the patients began to notice a decrease in asthma control, which was reflected in the results of the AST test, so in our opinion, it is rational to use the drug for 6 to 9 months. The patients with asthma against the background of EBW or obesity have alternative ways to solve the problem of asthma control, namely, studying in asthma school against the background of pharmacological correction drugs bacterial lysate and inosine promobas (RRR = 0.75, NNT = 2.12).

Keywords


bronchial asthma, excessive body weight, obesity, therapeutic-prophylactic complex, pharmacological correction, Asthma school

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References


http://www.who.int/en/news-room/fact-sheets/detail/asthma

Global Asthma Report 2014 http://www.globalasthmareport.org/resources/Global_Asthma_Report_2014.pdf

Data Proxima research, 10 2017 (Prevalence of perennial severe allergic asthma in Italy and efficacy of omalizumab in its management: PROXIMA - an observational, 2 phase, patient report outcomes study. Clinical and Molecular Allergy 13 (1) • December 2015)

Order of the Ministry of Health of Ukraine dated July 23, 2018 No. 1367 "On approval of the Register of Medicinal Products, the cost of which is subject to reimbursement as of July 23, 2018"

Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA), 2017; available from: www.ginasthma.org

NRAD, National Review of Asthma Deaths, Royal College of Physicians. Why Asthma Still Kills? The National Review of Asthma Deaths (NRAD) [online] 2014.Availablefrom: https: //www.rcplondon.ac.uk/projects/outputs/why-asthma-still-kills [Last accessed: December 2016

Cynthia Wilson Baffi, Daniel Efrain Winnica et al. Holguin Asthma and Obesity: Mechanisms and Clinical Implications Baffi et al. Asthma Research and Practice (2015) 1: 1

Yeh K.E.H., Skowronsky M.E., Coreno A.J. et al The effect of obesity on the severity and the therapeutic response of acute episodes of asthma. Journal of Asthma. 2014; 48 (6): 546-552.

Scott H. et al. The Airway Inflammation is Augmented by Obesity and Fatty Acids in Asthma. European Respiratory Journal. 2011; 38 (3): 594-602

Schatz M., Robert S. Zeiger. Overweight / Obesity and Risk of Seasonal Asthma Exacerbations The Journal of Allergy and Clinical Immunology: In Practice 2013; 6: 618-622

Complementary, Alternative, and Integrative Therapies for Asthma, Richard J Martin, MD, May 14, 2018

Price D., Fletcher M., van der Molen T. Asthma control and management in 8,000 European patients: the recognition of Asthma and LInk to Symptoms and Experience. NPJ Prim Care Respir Med. June 12, 2014; 24: 14009.

Therapeutic Physical Culture: Textbook. for studio higher studying Institution / SN Popov, N.M. Valeev, T.S. Garaseva and others, pp. 53-63

Clinical and Immunological Benefits of OM-85 Bacterial Lysate in Patients with Allergic Rhinitis, Asthma, and COPD and Recurrent Respiratory Infections. Koatz AM1, Coe NA2, Cicerán A3, Alter AJ4. Send toLung Aug. 2016; 194 (4): 687-97;

The Effect of the Oral Bacterial Extract OM-85 BV is an Asthma Control-Prospective Study by Antonios Christopoulos1, Lilia Pandel 2 and Panagiotis Demopoulos, British Journal of Medicine and Medical Research, ISSN: 2231-0614, Vol. 4, Issue .: 1 (01-10 January)].

Papadopoulos, N.G. Mechanism of virus-induced asthma exacerbations: state-oftheart. A GA2LEN and InterAirways document / N.G. Papadopoulos, P. Xepapadaki, P.Mallia et al. // Allergy. - 2007. - No. 62. - p. 457-470.].




DOI: http://dx.doi.org/10.5281/zenodo.1464169

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