Potential health benefits of aloe vera

Natalia Mikołajczak


Introduction and aim: Aloe vera was known in antiquity, and then its versatile healing and cosmetic properties were used. It is a rich source of many chemical compounds; it has been shown that there are 75 biologically active compounds, i.e. vitamins, minerals, enzymes, sugars, phenolic compounds, sterols, amino acids. The aim of this article was to review the literature and gather information on the health benefits of aloe vera and its products.

Brief description of the state of knowledge: There are many studies in the available literature on the influence of aloe vera and its products on human health. Studies carried out with the use of an aloe gel extract have shown that methanol and acetone solutions have maximum radical scavenging abilities. Other sources report that the use of aloe vera had a beneficial effect on the treatment of first and second degree burns, in addition the use of aloe vera gel in 63 male wounded rats increased the healing power of wounds than in other groups. Aloe vera juice is useful in the treatment of gastrointestinal problems, such as indigestion, yeast, heartburn and irritable bowel syndrome. Aloe vera extract increased cell tolerance to glucose in healthy and diabetic rats, and the use of aloe vera juice (4 - 14 weeks) had a significant hypoglycemic effect.

Summary: The collected literature data show that aloe vera, as well as its products have a beneficial influence of human health. They exhibit properties such antioxidant, anti-inflammatory, anti-cancer, antimicrobial, immunomodulatory, lipid and blood sugar lowering properties, and also accelerate the healing of wounds and burns. Aloe vera also has a beneficial effect on people's appearance (skin, hair, nails), thanks to which it finds a wide use in the cosmetics industry. Despite so many benefits, people should pay attention to the side effects of using aloe vera. It is also important to continue research (both with animals and people) related to the influence of this plant and its products on health.


aloe vera; health benefits; aloe vera leaves; aloe vera gel; aloe vera juice

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Agarry OO, Olaleye MT, Bello-Michael CO. Comparative antimicrobial activities of Aloe Vera gel and leaf. Afr J Biotechnol. 2005; 4(12):1413-1414.

Ahlawat KS, Khatkar BS. Processing, food applications and safety of aloe vera products: a review. J Food Sci Technol. 2011; 48(5):525–533.

Amin K, Ozgen S, Selamoglu Z. Aloe Vera: a miracle plant with its wide-ranging applications. Pharm Pharmacol Inter J. 2018; 6(1):1-2.

Athiban PP, Borthakur BJ, Ganesan S, Swathika B. Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating guttapercha cones. J Conserv Den. 2012; 15(3):246-248.

Azghani AO, Williams I, Holiday BD, Johnson AR. A Beta-linked mannan inhibits adherence of Pseudomonas aeruginosa to human lung epithelial cells. Glycobiology. 1995; 5(1):39-44.

Bawankar R, Singh P, Subramanian B. Bioactive compounds and medicinal properties of Aloe vera L.: An update. J Plant Sci. 2014; 2(3):102-107.

Boudreau MD, Mellick PW, Olson GR, Felton RP, Thorn BT, Beland FA. Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis miller (aloe vera) in F344/N rats. Toxicol Sci. 2013; 131(1):26-39.

Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, Suri J, Bhadauria M, Singh B. Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol. 2007; 111(3):560-566.

Chandrakar M, Palekar S, Chirade S, Fafiz SAM. Hypocholesterolemic effect of Aloe vera (L.) extract on high cholesterol fed calotes versicolor Daudin. Asian J Exp Sci. 2008; 22(3):295-298.

Che QM, Akao T, Hattori M, Kobashi K, Namba T. Isolation of human intestinal bacteria capable of transforming barbaloin to aloe-emodin anthrone. Planta Med. 1991; 57(1):15-19.

Choi S, Chung MH. A review on the relationship between Aloe vera components and their biologic effects. Semin Integr Med. 2003; 1:53-62.

Cieślik E, Turcza K. Właściwości prozdrowotne aloesu zwyczajnego Aloe vera (L.) Webb. (Aloe barbadensis Mill.). Post Fitoter. 2015; 2:117-124.

Cui Y, Ye Q, Wang H, Li Y, Yao W, Qian H. Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol-induced hepatotoxicity in mice. J Sci Food Agr. 2013; 94:1764-1771.

Dana N, Haghjooy Javanmard SH, Asgary S, Asnaashari H, Abdian N. Back to browse issues page anti-atherosclerotic effects of Aloe Vera in hypercholesterolemic rabbits. JBUMS. 2012; 14(4):34-37.

de Rodríguez DJ, Hernández-Castillo D, Rodríguez-García R, Angulo-Sanchez JL. Antifungal activity in vitro of Aloe vera pulp and liquid fraction against plant pathogenic fungi. Ind Crop Prod. 2005; 21(1):81-87.

El-Shemy HA, Aboul-Soud MA, Nassr-Allah AA, Aboul-Enein KM, Kabash A, Yagi A. Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction. Curr Med Chem. 2010; 17:129-138.

Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohyd Polym. 1999; 39:109–117.

Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. The antidiabetic activity of Aloes: Preliminary clinical and experimental observations. Horm Res. 1986; 24(4):286-294.

Heggers P, Pineless GR, Robson MC. Dermaide Aloe/Aloe vera gel: Comparison of the antimicrobial effects. Am J Med Technol. 1979; 41:293-294.

Ishii Y, Tanizawa H, Takino Y. Studies of Aloe. V. Mechanism of cathartic effect. Biol Pharm Bull. 1994; 17(5):651-653.

Ito S, Teradaira R, Beppu H, Obata M, Nagatsu T, Fujita K. properties and pharmacological activity of carboxypeptidase in Aloe arborescens Mill. var. Natalensis Berger. Phytother Res. 1993; 7(7):26-29.

Jambor J. Zielarstwo w Polsce – stan obecny i perspektywy rozwoju. Post Fitoter. 2007; 2:78-81.

Joseph B, Justin Raj S. Pharmacognostic and phytochemical properties of Aloe vera Linn. - An overview. Int J Pharm Sci Rev Res. 2010; 2:106-110.

Kemp MC, Kahlon JB, Chinnah AD, Carpenter RH, McAnalley BH, McDaniel HR, Shan-non WM. In vitro evaluation of the antiviral effects of acemannan on the replication and pathogenesis of HIV-1 and other enveloped viruses: Modification of the processing of glycoprotein glycoprotein precursors. Antiviral Res. 1990; 13(1):83.

Kukułowicz A, Steinka I. Aloes – możliwość wykorzystania jako suplementu diety. Probl Hig Epidemiol. 2010. 91(4):632-636.

Kumar S, Yadav JP. Ethnobotanical and pharmacological properties of Aloe vera: A review. J Med Plant Res. 2014; 8:1387-1398.

Kwieciński A. Witaminy w leczeniu różnych schorzeń. Farmaceutyczny Przegląd Naukowy. 2007; 7-8:49-55.

Langmead L, Feakins RM, Goldthorpe S. Randomized, doubleblind, placebo-controlled trial of oral Aloe vera gel for active ulcerative colitis. Aliment Pharm Ther. 2004; 19:739-747.

Lin KY, Uen YH. Aloe-emodin, an anthraquinone, In vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells. Oncol Lett. 2010; 1:541-547.

Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, Mora A, Porro G. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo. 2009; 23(1):171-175.

López A, de Tangil MS, Vega-Orellana O, Ramírez AS, Rico M. Phenolic constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain). Molecules. 2013; 18(5):4942-4954.

Maenthaisong R, Chaiyakunapruk N, Niruntraporn S. The efficacy of Aloe vera for burn wound healing: A systematic review. Burns. 2007; 33(6):713-718.

Mariita RM, Orodho JA, Okemo PO, Kirimuhuzya C, Otieno JN, Magadula JJ. Methanolic extracts of Aloe Secundiflora Engl. inhibits in vitro growth of tuberculosis and diarrhea-causing bacteria. Pharmacognosy Res. 2011; 3(2):95-99.

Matejczyk M, Golonko A, Chilmon E. Aloe vera – wybrane właściwości biologiczne. Budownictwo i Inżynieria Środowiska. 2017; 8(4):191-195.

Misawa E, Tanaka M, Nabeshima K, Nomaguchi K, Yamada M, Toida T, Iwatsuki K. Administration of dried Aloe vera gel powder reduced body fat mass in diet induced obesity (DIO) rats. J Nutr Sci Vitaminol. 2012; 58(3):195–201.

Moniruzzaman M, Rokeya B, Ahmed S, Bhowmik A, Khalil MI, Gan SH. In vitro antioxidant effects of Aloe barbadensis Miller Extracts and the potential role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats. Molecues. 2012; 17:12851-12867.

Moriyama M, Mariyama H, Uda J, Kubo H, Nakajima Y, Goto A, Akaki J, Yoshida I, Matsuoka N, Hayakawa T. Beneficial effects of the genus Aloe on wound healing, cell proliferation, and differentiation of epidermal keratinocytes. PLoS One. 2016; 11(10):1-15.

Mortan JF. Folk uses and commercial exploitation of Aloe vera leaf pulp. Econ Bot. 1961; 15:311-319.

Nandal U, Bhardwaj RL. Aloe vera for human nutrition, health and cosmetic use - A review. Int Res J Plant Sci. 2012; 3(3):038-046.

Pugh N, Ross SA, ElSohly MA, Pasco DS. Characterization of aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 2001; 49(2):1030-1034.

Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2014; 5(1):21-26.

Rahmani AH, Aldebasi YH, Srikar S, Khan AA, Aly SM. Aloe vera: Potential candidate in health management via modulation of biological activities. Pharmacognosy Rev. 2015; 9(18):120-126.

Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol P. 2006; 33:232–237.

Rajeswari R, Umadevi M, Sharmila Rahale C, Pushpa1 R, Selvavenkadesh S, Sampath Kumar KP, Bhowmik D. Aloe vera: the miracle plant its medicinal and traditional uses in India. J Pharmacogn Phytochem. 2012; 1(4):118–124.

Reddy Uma CH, Reddy SK, Reddy J. Aloe vera - A Wound Healer. Asian J Oral Health Allied Sci. 2011; 1:91-92.

Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, Shrivasrava AK, Kumar A, Pandey KD. Therapeutic and medicinal uses of aloe vera: a review. Pharmacol Pharm. 2013; 4:599-610.

Saini M, Goyal PK, Chaudhary G. Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice. J Environ Pathol Toxol Oncol. 2010; 29(2):127-135.

Sanchez-Machado DI, Lopes-Cervantes J, Sendon R. Aloe vera: Ancient knowledge with new frontiers. Trends Food Sci Tech. 2017; 61:94-102.

Sanders B, Ray AM, Goldberg S, Clark T, McDaniel HR, Atlas SE, Farooqi A, Konefal J, Lages LC, Lopez J, Rasul A, Tiozzo E, Woolger JM, Lewis JE. Anti-cancer effects of aloe-emodin: A systematic review. J Clin Trans Res. 2017; 3(4):1-14.

Saoo K, Miki H, Ohmori M, Winters WD. Anti-viral activity of Aloe extracts against cytomegalovirus. Phytother Res. 1990; 10(4):348- 350.

Saritha V, Anilakumar KR, Khanum F. Antioxidant and antibacterial activity of Aloe vera gel extracts. Int J Pharm Biol Arch. 2010; 1(4):376-384.

Shalabi M, Khilo K, Zakaria MM, Elsebaei MG, Abdo W, Awadin W. Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells. Asian Pac J Trop Biomed. 2015; 5(5):375-381.

Shireen F, Manipal S, Prabu D. Anti-fungal activity of Aloe vera: In vitro study. SRM J Res Dent Sci. 2015; 6(2):92-95.

Sitara U, Hassan N, Naseem J. Antifungal activity of aloe vera gel against plant pathogenic fungi. Pak J Bot. 2011; 43(4):2231-2233.

Suboj P, Babykutty S, Srinivas P, Gopala S. Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells. Pharmacol. 2012; 89:91-98.

Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN. Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrob Agents Ch. 1991; 35(12):2463-2466.

Takzare N, Hosseini M, Hasanzadeh G, Mortazavi H, Takzare A, Habibi P. Influence of Aloe Vera gel on dermal wound healing process in rat. Toxicol Mech Methods. 2009; 19:73–77.

Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, Toida T, Hayasawa H, Takase M, Inagaki M, Higuchi R. Identification of five phytosterols from Aloe vera gel as antidiabetic compounds. Biol Pharm Bull. 2006; 29(7):1418-1422.

Waller J, Klopfenstein TJ, Poos M. Distillers feeds as protein sources for growing ruminants. Anim Sci J. 1980; 51(5):1154-1167.

West DP, Zhu YF. Evaluation of Aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Am J Infect Control. 2003; 31(1):40-42.

Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003; 26(4):1277-1294.

Zhang L, Tizard IR. Activation of mouse macrophage cell line by acemannan; the major carbohydrate fraction of Aloe vera. Immunopharmacol. 1996; 35:119-128.

DOI: http://dx.doi.org/10.5281/zenodo.1434046


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