Current nosological status, pathomechanism and treatment of catatonia

Magdalena Julia Jabłońska, Katarzyna Lipa, Patryk Kaczor, Kamil Leis, Krystian Kałużny, Przemysław Gałązka

Abstract


Catatonia, otherwise known as catatonic syndrome is a frequent neuropsychiatric syndrome characterized mainly by motor disorders. There are many somatic and psychiatric dysfunctions, and the multitude of symptoms included in it make a problem in diagnosis. Moreover, until now the mechanism of pathophysiology of catatonia has not been recognized. Among the hypotheses proposed, one may find theories concerning dysregulation of neurotransmission within the dopamineergic D2 or GABA-A-ergic receptors. For years, catatonia was closely related to schizophrenia, but with the publication of the 5th edition of the Diagnostic and Statistical Manual of Psychiatric Disorders - DSM-5, these disorders were separated, creating the hope that catatonia would be considered as a separate disease entity in the future. Pharmacotherapy involves the use of benzodiazepines in the first line, which are effective in most patients. An alternative is N-methyl-D-aspartic acid (NMDA) antagonists and atypical antipsychotic drugs, the use of which is controversial due to the high risk of neuroleptic malignant syndrome, which is a direct threat to life. In the case of catatonia resistant to benzodiazepines, electroconvulsive therapy (ECT) is effective. At the same time, in order to increase the effectiveness of treatment, electroconvulsive therapy and benzodiazepines are used in parallel, which brings satisfactory results.

Keywords


catatonia; neuroleptic malignant syndrome; benzodiazepines; electroconvulsive therapy; antagonists of N-methyl-D-aspartic acid; atypical antipsychotics

Full Text:

PDF

References


American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. DSM 5. American Psychiatric Publishing, Washington, DC, 2013.

Madigand J, Lebain P, Callery G, Dollfus S. Catatonic syndrome: From detection to therapy. Encephale. 2016 Aug;42(4):340-5.

Bush G, Fink M, Petrides G, Dowling F, Francis A. Catatonia. I. Rating scale and standardized examination. Acta Psychiatr Scand 1996;93:129–36.

Daniels J. Catatonia: clinical aspects and neurobiological correlates. J Neuropsychiatr Clin Neuro Sci. 2009;21(4):371–380.

Clinebell K, Azzam PN, Gopalan P, Haskett R. Guidelines for preventing common medical complications of catatonia: case report and literature review. J Clin Psychiatry. 2014;75(6):664–651.

Ungvari GS. Catatonia in DSM-5: controversies regarding its psychopathology, clinical presentation and treatment response. Neuropsychopharmacol Hung. 2014;16(4):189–194.

Rosebush PI, Mazurek MF. Catatonia and its treatment. Schizophr Bull. 2010;36(2):239–242.

Northoff G. What catatonia can tell us about ‘top-down modulation’: a neuropsychiatric hypothesis. Behav Brain Sci 2002; 25: 555–577.

Rasmussen SL, Michael F, Mazurek MF, Rosenbush PI. Catatonia: our current understanding of its diagnosis, treatment and pathophysiology. World J Psychiatry. 2016;6(4):391–398.

Carroll BT, Appiani F: Katatonia: jakie jest najlepsze podejście lecznicze po rozpoznaniu. Psychiatria po Dyplomie 2010; 7(4):11-12.

Northoff G, Steinke R, Czcervenka C, et al. Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: investigation of in vivo benzodiazepine receptor binding. J Neurol Neurosurg Psychiatry 1999; 67(4): 445–450.

Northoff G. Catatonia and neuroleptic malignant syndrome: psychopathology and pathophysiology. J Neural Transm 2002;109(12):1453–1467.

Northoff G. Brain imaging in catatonia: current findings and a pathophysiologic model. CNS Spectr. 2000;5:34–46.

Henderson VW, Wooten GF. Neuroleptic malignant syndrome: a pathogenetic role for dopamine receptor blockade? Neurology 1981;31:132–7.

Reilly TJ, Cross S, Taylor DM, Haslam R, Tomlin SC, Gaastra B. Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription. SAGE Open Med Case Rep. 2017 Mar 31;5.

Sienaert P, Dhossche D, Vancampfort D, De Hert M, Gazdag G. A clinical review of the treatment of catatonia. Front Psych. 2014;5:181.

Tandon R, Hecker A, Bustillo J, Barch DM, Gaebel W, Gur RE, Malaspina D, Owen MJ, Schultz S, Tsuang M, van Os J, Carpenter W. Catatonia in DSM-5. Schizophr Res. 2013;150:26–30.

Wilcox J.A., Reid D.P. The syndrome of catatonia. Behav. Sci. 2015;5:576–588.

Walther S, Strik W: Catatonia. CNS Spectr. 2016 Aug;21(4):341-8.

Carroll B. T., et al. Katatonia: a new conceptual understanding of catatonia and a new rating scale. 2008;5(12):42–50.

F. Luchini, N. Bartolommei, A. Benvenuti, M. Mauri, L. Lattanzi: Catatonia from the first descriptions to DSM 5. Journal of Psychopathology 2015;21:145-151.

Belaizi M, Yahia A, Mehssani J, Bouchikhi Idrissi ML, Bichra MZ. Acute catatonia: Questions, diagnosis and prognostics, and the place of atypical antipsychotics. Encephale. 2013;39:224–231.

Prakash J, Prabhu HRA, Srivastava K, Bhat PS, Shashikumar R: Catatonia: Towards an Integrated Neuropsychiatric Approach. Delhi Psychiatry Journal 2010; 13(2): 229-235.

Petrides G, Divadeenam KM, Bush G, Francis A. Synergism of lorazepam and electroconvulsive therapy in the treatment of catatonia. Biol Psychiatry. 1997 Sep 1;42(5):375-81.

Van Dalfsen AN, Van Den Eede F, Van Den Bossche B, Sabbe BG. Benzodiazepines in the treatment of catatonia, Tijdschr Psychiatr. 2006;48(3):235-239.

Sharma CM, Jena S, Sharma D, Agrawal RP. Role of lorazepam challenge test in childhood catatonia. J Pediatr Neurosci 2014;9(3):301–303.

Tibrewal P, Narayanaswamy J, Zutshi A, Srinivasaraju R, Bada Math S. Response rate of lorazepam in catatonia: a developing country’s perspective. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1520–1522.

Hawkins JM, Archer KJ, Strakowski SM, Keck PE., Jr. Somatic treatment of catatonia. Int. J. Psychiatry Med. 1995;25:345–369.

Manjunatha N, Saddichha S, Khess CR. Idiopathic recurrent catatonia needs maintenance lorazepam: case report and review. Aust N Z J Psychiatry. 2007;41:625–627.

Huang YC, Lin CC, Hung YY, Huang TL. Rapid relief of catatonia in mood disorder by lorazepam and diazepam. Biomed. J. 2013;36:35–39.

Schmider J, Standhart H, Deuschle M, Drancoli J, Heuser I. A double-blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. Biol Psychiatry (1999) 46(3):437–441.

Brown M, Freeman S. Clonazepam withdrawal-induced catatonia. Psychosomatics. 2009;50:289–292.

Pritchett D. B., Seeburg P. H. Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem 1990; 54:1802–1804.

Carroll BT, Lee JWY, Appiani F, Thomas C. Farmakoterapia katatonii. Psychiatria po Dyplomie 2010; 17(4): 27-33.

Carroll BT, Goforth HW, Thomas C, Ahuja N, McDaniel WW, Kraus MF, Spiegel DR, Franco KN, Pozuelo L, Muñoz C. Review of adjunctive glutamate antagonist therapy in the treatment of catatonic syndromes. J Neuropsychiatry Clin Neurosci. 2007;19:406–412.

Pelzer AC, van der Heijden FM, den Boer E.Systematic review of catatonia treatment. Neuropsychiatr Dis Treat. 2018 Jan 17;14:317-326.

. Walstra AN, den Broek MV, Giltay EJ, van Paassen J, van Noorden MS. Successful amantadine treatment of a patient with ECT-resistant catatonia. Tijdschr Psychiatr. 2016;58(8):599-602.

Unal A, Bulbul F, Alpak G, Virit O, Copoglu US, Savas HA. Effective treatment of catatonia by combination of benzodiazepine and electroconvulsive therapy. J ECT. 2013;29:206–209.

Chen CW, Lin SH, Huang LC, Yang YK. Transcranial direct current stimulation (tDCS) improved psychomotor slowness and decreased catatonia in a patient with schizophrenia: Case report. Kaohsiung J Med Sci. 2018 Jun;34(6):360-362.




DOI: http://dx.doi.org/10.5281/zenodo.1412123

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)