A retrospective analysis of 27 patient case histories with pathomorphologically confirmed diagnosis of endometrial cancer (EC) showed that the most common and statistically significant risk factors for the development of uterine body cancer are: age of a woman above 50 years, heredity and genetic predisposition, late menopause, polycystic ovary syndrome, thyroid gland diseases, diabetes mellitus, obesity, infertility of hormonal genesis, arterial hypertension, inflammatory diseases of female genital organs, early menarche. Hereditary non-polypous colorectal cancer (11.68%, 95% CI 0.59-227.89), and hepatobiliary system diseases (2.50%, 95% CI 0.71-8.72) according to our results are not statistically significant. In order to determine the risk of EC development, 3 rules based on the “AssociationRules method” have been developed. They are: the combination of late menopause and heredity can lead to the development of EC with a probability of 59.25% and accuracy of 88.88%, while the correlation coefficient is 88.88%; the presence of obesity or heredity in a woman above 50 years of age can lead to EC with a probability of 59.25% and accuracy of 80.00% with a correlation coefficient of 84.32%; the development of EC in women above 50 years of age with a late-onset menopause is possible with a probability of 62.96% and accuracy of 94.44%, while correlation coefficient is 89.59% in this case.

risk factor, endometrial cancer

Тkachenko L. В., et al. Risk prognostic factors of endometrial hyperplasic processes development under menopause // Volgograd Scientific-Med. J. – 2013. - № 4. – P. 43 - 47.

Chernukha G. Е. Hyperplasia of endometrium: perspectives of the problem development // Obstetrics & Gynecology. – 2009. – № 4. – P. 11–15.

Sorosky J. I. Endometrial cancer / J. I. Sorosky // Obstet. Gynecol. – 2012. – Vol. 120. – Р. 383–397.

Коrnienko S. М. Endometrial hyperplasic processes in women at late reproductive and premenopausal period // Herald for Soc Hygiene and Health Care management in Ukraine. - 2017. - № 2 (72). - P. 39-47.

Nachajova M, Mersakova S, Sivakova J, Krivus S, Szepe P, Hatok J, Adamkov M. New molecular aspects of endometrial carcinoma //Neuro Endocrinol Lett.- 2015;36(7):638-43.

Ali A. T. Reproductive factors and the risk of endometrial cancer // Int J Gynecol Cancer. - 2014;24(3):384-93.

Uchikova E, Uchikov P, Parahuleva P. Obesity and endometrial сarcinogenesis // Akush Ginekol (Sofiia).- 2015;54(9):34-7.

Fedorenko Z. P., et al. Cancer in Ukraine, 2016–2017: morbidity, mortaliyu, indexes of oncological service // Bull Nat Cancer-register Ukr. — Kiev, 2018. — № 19. — 136 p.

Clinical and pathogenic features of endometrium hyperplastic processes in women of premenopausal period // Rus Med J “ Med Review”.- 2018.- N1 (I) .- P. 67-71.

Vlasov Р. С. Clinical meaning of methylate genes-suppressors of tumor growth at pathological prosesses of endometrium in reproductive age women: synopsis of a candidate thesis: specialty 14.01.01 «Obstetrics & Gynecology. – Moscow, 2011. – 21 p.

Vdovichenko Yu. P. Modern management of diagnostics and treatment of hyperplastic processes of endometrium (review of literature // Health of a Woman. – 2012. – № 9. – P. 45–53.

Unanian А. l. Prognosis of uterus body cancer in women with hyperplastic prosesses of endometriamin premenopausal period Прогнозирование рака тела матки у женщин с гиперпластическими процессами эндометрия в пременопаузальном возрасте // Obstetrics and Gynecology. Reproduction. - 2012. - №2 - P. 18-24.

Senechal C, Cottereau E, de Pauw A, Elan C, Dagousset I, Fourchotte V. Environmental and genetic risk factors for endometrial carcinoma.Bull Cancer.2015;102(3):256-69.

Sheshukova N.A., et al. Hyperplastic processes of endometrium: etiology, pathogeneses, clinics, diagnostics, treatment // Obst & Gynecol. – 2011. – № 4. – P. 16–21.

Shaw E, Farris M, McNeilJ, Friedenreich C. Obesity and Endometrial Cancer. Recent Results // Cancer Res. - 2016;208:107-136.

Zhang Y, Liu H, Yang S, Zhang J, Qian L, Chen X. Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers. 2014;29(1):e21-9.

Ali AT. Risk factors for endometrial cancer.// Ceska Gynekol. 2013;78(5):448-59.

Ketabi Z, Mosgaard BJ, Gerdes AM, Ladelund S, Bernstein IT. Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer. Obstet Gynecol. 2012;120(5):1005-12.

Gao J, Yang G, Wen W, Cai QY, Zheng W, Shu XO, Xiang YB. Impact of known risk factors on endometrial cancer burden in Chinese women. Eur J Cancer Prev. 2016;25(4):329-34.