Content of protein oxidative modification products and nitrogen monoxide metabolites in the kidneys and myocardium of rats with streptozotocin-induced diabetes in dynamics of cerebral ischemia-reperfusion

O. V. Tkachuk, S. S. Tkachuk, V. F. Myslytskyi, V. P. Gavaleshko, O. V. Yasinska, M. A. Povar, S. V. Boshtan, T. P. Savchuk

Abstract


Introduction. Acute disorders of cerebral circulation similar to diabetes mellitus (DM) cause long-term multiple organ effects, although pathogenesis of internal organs injury in association with DM and cerebral ischemia-reperfusion has not been investigated completely.
The aim of the study. To study the dynamics of the content of protein oxidative modification and metabolites in the myocardium and kidneys of rats with DM complicated by cerebral ischemia-reperfusion.
Results. The content of protein oxidative modification products in the tissues of the kidneys and myocardium and the content of nitrogen monoxide metabolites in the cortical and medullary substance of the kidneys were found to decrease in the early ischemic-reperfusion period in rats without DM. In rats with DM early post-ischemic changes are restricted by the increase of nitrogen oxide metabolites content in the renal medullary substance. Total remote changes of the examined parameters are found in the myocardium of rats without DM and the medullary substance of the kidneys in rats with DM.
Conclusions. Diabetes mellitus eliminates or restricts the reaction of the examined indices peculiar for control animals in both periods of observation in all the examined tissues except the medullary substance of the kidneys on the 12th day of the post-ischemic period.

Keywords


diabetes mellitus, nephropathy, cardiomyopathy, cerebral ischemia-reperfusion.

Full Text:

PDF

References


Aneja A., Tang W.H., Bansilal S., Garcia M.J., Farkouh M.E. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am. J. Med. .2008; 121(9):748-57.

Ernande L., Derumeaux G. Diabetic cardiomyopathy: myth or reality? Arch. Cardiovasc. Dis. 2012; 105(4): 218-25.

Stevens L.A., Li S., Kurella Tamura M., Chen S.C., Vassalotti J.A., Norris K.C., Whaley-Connell A.T., Bakris G.L., McCullough P.A.Sowers Сomparison of the CKD epidemiology collaboration (C KD-EPI) and modification of diet in renal disease (MDRD) study equations: prevalence of and risk Factors for Diabetes Mellitu s in CKD in the Kidney Early Evaluation Program (KEEP). Am. J. Kidney Dis. 2011; 57(Is.3, Suppl. 2): 24-31.

Shao D., Liu J., Ni J., Wang Z., Shen Y., Zhou L., et al. Suppression of XBP1S Mediates High Glucose-Induced Oxidative Stress and Extracellular Matrix Synthesis in Renal Mesangial Cell and Kidney of Diabetic Rats. PLoS One. 2013; 8(2): e56124.

Boghdady N.A., Bard G.A. Evaluation of oxidative stress markers and vascular risk factors in patients with diabetic peripheral neuropathy. Cell. Biochem. Funct. 2012; 30(4): 328–34.

Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression / O. Brouwers, J.M. de Vos-Houben, P.M. Niessen [et al.] // Int. J. Mol. Sci. – 2013. – Vol.14, №8. – Р. 15724-15739.

Falcão-Pires I., A.F. Leite-Moreira. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail. Rev. 2012; 17(3): 325-44.

Sedeek M., Callera G., Montezano A. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am. J. Physiol. Renal Physiol. 2010; 299(№6): 1348-58.

Muscari A., Collini A., Fabbri E., Giovagnoli M., Napoli C., Rossi V., et al. Changes of liver enzymes and bilirubin during ischemic stroke: mechanisms and possible significance. BMC Neurol. 2014;14(122). doi: 10.1186/1471-2377-14-122.

Chiu N.L., Kaiser B., Nguyen Y.V., Welbourne S., Lall C., Cramer S.C. The Volume of the Spleen and its Correlates after Acute Stroke. J. Stroke Cerebrovasc. Dis. 2016; 25(12): 2958–61.

Hassan Y., Aziz N.A., Al-Jabi S.W., Looi I. Evaluation of antihypertensive therapy among ischemic stroke survivors: impact of ischemic heart disease. J. Cardiovasc. Pharmacol. Ther. 20104; 15(3): 282-88.

Banerjee A., Lim C.C., Silver L.E., Welch S.J. Familial history of stroke is associated with acute coronary syndromes in women. Circ. Cardiovasc. Genet. 2011; 4(1). Р.9-15.

Rashidi A., Sehgal A.R., Rahman M., O'Connor A.S. The case for chronic kidney disease, diabetes mellitus, and myocardial infarction being equivalent risk factors for cardiovascular mortality in patients older than 65 years. Am. J. Cardiol. 2008; 102(12): 1668-73.

Cianciolo G., De Pascalis A., Di Lullo L., Ronco C., Zannini C., La Manna G. Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First? Cardiorenal. Med. 2017; 7(4): 255–66.

Tkachuk, S.S., Lenkov, A.M. Ekspresiia bilkiv Hif-1α, р53 ta Bcl-2 v golovnomu mozku za umov dvobichnoi karotidnoi ishemii-reperfuzii na tli tsukrovogo diabetu v samtsiv-shchuriv. Klinichna ta eksperimentalna patologiia. 2010; 2(32): 111–113.

Skibo G.G. Ispolzovanie razlichnikh eksperimentalnikh modelei dlia izucheniia kletochnikh mechanizmov іshemicheskogo porazheniia mozga. Patologija. 2004; 1(1): 22-30.

Mahalyas VM, Mikhyeyev AO, Rohovyy YuYe. Suchasni metody eksperymental'nykh ta klinichnykh doslidzhen' tsentral'noyi naukovo-doslidnoyi laboratoriyi Bukovyns'koyi derzhavnoyi medychnoyi akademiyi. Chernivtsi; 2001. 42 s.




DOI: http://dx.doi.org/10.5281/zenodo.1344631

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)