Association between IL-1β, IL-8, IL-10 and VEGF polymorphisms and risk of odontogenic maxillofacial infections

A. Yu. Adubetskaya, S. A. Schneider, V. O. Ulianov


Background. Nowadays it is being reported an increased number of cases of generalization of odontogenic infections which are caused by dental caries, periodontal diseases and other oral diseases. The beginning and progression of diseases depend on individual genetic profile of patient, but data about the role of genetic factors in purulent-inflammatory diseases of maxillofacial area pathogenesis are limited now.
The aim of this study was to assess the possible association between IL-1β, IL-8, IL-10 and VEGF polymorphisms and risk of odontogenic maxillofacial infections.
Materials and methods
80 patients with odontogenic maxillofacial infection (with and without diabetes mellitus) and 20 donors were examined. All patients’ with odontogenic maxillofacial infection groups were operated and received antibiotic and detoxification therapy. Polymorphism in IL-1B +3954C/T (rs1143634), IL-8 -251T/A (rs4073), IL-10 -1082G/A (rs1800896) and VEGF -634 G/C (rs 2010963) were assessed by polymerase chain reaction. Odds ratio (OR) with 95% confidence interval (CI), Chi-square test were used for statistical analyses.
Results. No association observed between VEGF -634 G/C polymorphism and risk of odontogenic maxillofacial infections in patient without diabetes mellitus using all the genetic models. In patients with diabetes mellitus observed association between VEGF -634 G/C polymorphism and odontogenic maxillofacial infections in the codominant (OR=0,429, 95%СІ 0,185-0,994, р=0,046), heterozygous (OR=0,167, 95%СІ 0,048-0,574, р=0,004)and recessive (OR=0,194, 95%СІ 0,061-0,619, р=0,005) models.
Polimorphism IL-1B +3954C/T increased the risk of odontogenic maxillofacial infections in patient without diabetes mellitus in the codominant (OR=0,059, 95%СІ 0,023-0,151, р<0,001), homozygous (OR=0,021, 95%СІ 0,003-0,129, р<0,001), dominant (OR=0,028, 95%СІ 0,005-0,145, р<0,001) and recessive (OR=0,0074, 95%СІ 0,019-0,291, р<0,001) models. Polimorphism IL-10 -1082 G/A increased the risk of odontogenic maxillofacial infections in the codominant (OR=0,356, 95%СІ 0,146-0,870, р=0,021), heterozygous (OR=0,106, 95%СІ 0,028-0,399, р<0,001) and recessive (OR=0,143, 95%СІ 0,043-0,472, р<0,001) models. Aassociation between IL-8-251 T/A polymorphism and risk of odontogenic maxillofacial infections it was found only codominant (OR=0,444, 95%СІ 0,198-1,0, р=0,048) genetic model. In these cases the risk of odontogenic maxillofacial infections were similar in patient without and with diabetes mellitus.
Conclusion. The IL-1B (+3954C/T), IL-10 (-1082G/A) polymorphism increases odontogenic maxillofacial infections risk in patient without diabetes mellitus. The IL-1B (+3954C/T), IL-10 (-1082G/A) and VEGF (-634G/C) polymorphism increases odontogenic maxillofacial infections risk in patient with diabetes mellitus.


odontogenic maxillofacial infections, IL-1B, IL-10, IL-8, VEGF, polymorphism

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Huang TT, Liu TC, Chen PR, Tseng FY, Yeh TH, Chen YS. Deep neck infection: analysis of 185 cases. Head Neck. 2004;26(10):854–860.

Dolgushin II, Latyushina LS, Pavlienko VV The influence of immunocorrection on the trend of festering wound process and functional activity of neutrophils at the patients with odontogenic phlegmons of face and neck during the complex treatment [in russian] Vestnik novyih meditsinskih tehnologiy. 2008;15(2):198-200.

Fragiskos D. Oral surgery. 1st ed. Berlin: Springer; 2007. 205–206 p.

Chen MK, Wen YS, Chang CC, Huang MT, Hsiao HC. Predisposing factors of life-threatening deep neck infection: logistic regression analysis of 214 cases. J Otolaryngol.1998;27(3):141–144.

Zorina OA, Boriskina OA, Leonovich OA, Rebricov DV Genetic factors of aggressive periodontitis risk (matrix proteins, matrix proteases and their regulators). [in Russian] Stomatologiya. 2013;92(1):76–84.

Zorina OA, Boriskina OA, Rebricov DV Correlation of gene polymorphpism and risk of aggressive periodontal disease [in Russian]. Stomatologiya. 2013;92(4):28–30.

Grigorovich ESh, Pomorgailo EG, Khomutova EYu, Stepanov SS Clinical variations of chronic generalized periodontitis, genetic polymorphism and systemic production of inflamatory cytokines. [in Russian] Stomatologiya. 2015;94(5):11–16.

Grigorovich ESh The clinical course of chronic generalized periodontitis and polymorphisms of genes key inflamatory cytokines IL-1B, IL-1RN, TNFα, IL-4. [in Russian] Uralskiy meditsinskiy zhurnal. 2015;129(6):26–32.

Gasyuk NV Role of nuclear polymorphism transcription factor NF-kB1 in the pathogenesis general parodontitis [in Ukrainian]. Svit meditsini ta biologii. 2015;3(51), Part 1:28–31.

Grigorovich ESh, Gorodilov RV, Arsenteva KI Expression markers of innate and adaptive immunity in gingival biopsies of patients with chronic generalized periodontitis during treatment [in Russian] Stomatologiya. 2015;94(5):17–20.

Shimansky ShI, Chilikin VN, Malishev IYu, Suvorova IA, Rumyantsev VA, Denis AG Phagocytes protection of periodontium and its ways activation. [in Russian] Stomatologiya. 2013;92(5):64–69.

Fernandes KS, Glick M, de Souza MS, Kokron CM, Gallttini M Association between immunologic parameters, glycemic control, and postextraction complications in patients with type 2 diabetes. J Am Dent Assoc. 2015;146(8):592–599.

Mesia R, Gholami F, Huang H, Clare-Salzler M, Aukhil I, Wallet SM, Shaddox LM Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis. BMJ Open Diabetes Res Care. 2016;4(1):e000260.

Barć P, Płonek T, Baczyńska D, Pupka A, Witkiewicz W, Mastalerz-Migas A, Milnerowicz A, Antkiewicz M, Hałoń A, Skóra JP. Role of vascular endothelial growth factor in inducing production of angiopoetin-1 - in vivo study in Fisher rats. Pol J Pathol. 2017;68(4):326-329.

Matsumoto K, Ema M Roles of VEGF-A signalling in development, regeneration, and tumours. J.Biochem. 2014;156(1):1-10.

Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics. 5(1): 30–55.

Bensi G, Raugei G, Palla E, Carinci V, Tornese Buonamassa D, Melli M Human interleukin-1 beta gene. Gene 1987; 52(1): 95–101.

Dereka X, Mardas N, Chin S, Petrie A, Donos N A systematic review on the associaton between genetic predisposition and dental implant biological complications. Clin Oral Implants Res. 2012; 23(7):775-88.

Hamdy AA, Ebrahem MA The effect of interleukin-1 allele 2 genotype (IL-1a(-889) and IL-1b(+3954)) on the individuals susceptibility to peri-implantitis: casse-control study. J Oral Implantol. 2011;37(3):325-34.

Chen L, Ke Z, Zhou Z, Jiang X, Zhao Y, Zhang J Associacion of IL-1, 6 and 10 gene polymorphisms with susceptibility to recurent aphthous stomatitis: insights from a meta-analysis. Genet Test Mol Biomarkers. 2018;22(4):237-245.



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