The role of selenium in cancer treatment, cardiovascular diseases, thyroid gland

Monika Pierzak, Kamila Bożena Fortunka


Malignant tumors are diseases occurring in any population in the world, characterized by a high mortality [1]. In the developed countries are the second cause of death after cardiovascular diseases. Among the risk factors for many cancers, distinguished tastes bad habits. A new trend in academic research on the effects of inadequate supply of selenium in the diet at risk of developing cancer, in particular carcinoma of the colon, lung or prostate cancer. The role of selenium, looking also for prevention against cardiovascular events. Cardiovascular disease 50 years of age are the biggest threat to his countrymen. CSO data show since 1992 that the participation of these diseases in the total number of deaths decreased from 52% to 45.6% in 2012. Selenium deficiency also affects, for example, the development of thyroid disease. Autoimmune thyroiditis, hypothyroidism or crop neutral. Deiodinase are selenoenzymes, which play an essential role in the metabolism of thyroid hormones. Deiodinase, type 1, 2 is involved in the process dejodacji thyroxine [T4] for the active company in the form of 3,3 ', 5-triiodothyronine [T3] [34]. Selenium is a trace element was discovered in 1817 by Swedish chemist Berzelius. Until 1957 was considered, for the root of the toxic effects. Selenium is a trace element belonging to the micro [17,18,19]. As a building block and a redox active enzymes, the cytochrome is involved in metabolic processes in the cell. According to the National Academy of Sciences of the United States (NAS called. National Academy of Sciences), the average daily requirement for selenium (EAR- Estimated Average Requirements) and the recommended dose in the diet (RDA- Recommended Dietary Allowance) indicate selenium 45μg / day for adult women and adult man. Selenium is a trace element.


selenium; cancer; cardiovascular disease; thyroid disease

Full Text:


References 02.12.2017).

Woźniak J. Ludność w UE: prognoza 2008–2060. http:// egospodarka. pl/33899, Ludność w UE prognoza – 2008–2060, 1, 39, 1.html z dnia 20.03.2017 godz. 11.38.

Mastromarino V. Casenghi M. Testa M iwsp. Polypharmacy in heart failure patients. “CurrHeartFail Rep”. 11, 2014, 212-9.

Jarosz M. Normy żywienia człowieka.(red). Instytut Żywności i Żywienia. Warszawa 2017.

Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Calcium and Vitamin D. National Academy Press, Washington DC 2011.

Kunachowicz H, Czarnowska-Misztal E, Szczepańska A, Ners A. Podstawy żywienia człowieka. Wydawnictwo Szkolne i Pedagogiczne. Warszawa 1999.

Angielski S. Biochemia kliniczna i analityka. PZWL. Warszawa 1990.

B. Nutritional goldfinch. Practical Medicine 2000; 7 (8): 29-36.

Dietetyka, Helena Ciborowska, Anna Rudnicka. Wydawnictwo Lekarskie PZWL 2012.

Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Ntional Academy Press, Washington DC 2000.

Sunde RA. Selenium. [In:] O’Dell BL, Sunde RA et al. (eds.): Handbook of Nutritionally Essential Mineral Elements. Marcel Dekker Inc. New York 1997: 493-556.

Reilly C. Seleniu Duntas L.H., Benvega S.: Selenium: an element for life. Endocrine 2014; 48(3): 756-775 m in Food and Health. 2nd ed. Springer. London 2006.

Labunskyy V.M, Hatfield D.L, Gladyshev V.N. Selenoproteins: molecular pathways and physiological roles. Physiol. Rev. 2014; 94(3): 739-777.

Zeng H, Combs G. F. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. Journal of Nutritional Biochemistry 2008; 19: 1-7.

Gromadzińska J, Reszka E, Bruzelius K, Wąsowicz W, Åkesson B. Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur. J. Clin. Nutr. 2008; 47(2): 29-50.

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, 2000-, (17.07.2018).

Selenium and a Reduced Risk of Site-specific Cancers, FDA-2008-Q-0323, (17.07.2018).

Scientific Opinion on Dietary Reference Values for selenium. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 2014, 12(10), 3846.

Mangiapane E, Pessione A, Pessione E. Selenium and selenoproteins: an overview on different biological system. Curr. Protein Pept. Sci. 2014; 15(6): 598-607.

Murray RK, Granner DK, Meyes PA et al. Biochemia Harpera. Wydawnictwo Lekarskie PZWL. Warszawa 2005.

Reilly C. Selenium in Food and Health. 2nd ed. Springer. London 2006.

Hurst R, Collings R, Harvey LJ et al. EURRECA – estimating selenium requirements for deriving dietary reference values. Crit Rev Food Sci Nutr 2013; 53: 1077-1096.

U.S. Department of Health and Human Services and U.S. Department of Agriculture:2015-2020 Dietary Guidelines for Americans. 8th ed. 2015

; (20.07.2018).

Oldfield J.E. A brief history of selenium research: From alkali disease to prostate cancer (from poison to prevention). J. Anim. Sci. Online Supplement 2002; 11: 1.

Szczygieł B. Leczenie żywieniowe. Medycyna Praktyczna 2000; 7 (8): 29–36.

Karwowska K, Hartman- Sobczyńska R, Sobczyński P. Ocena metaboliczna chorego w oddziale intensywnej terapii. Farmacja Współczesna 2011; 4: 127-132.

Kłęk S, Jarosz J, Jassem J, Kapała A, Krawczyk J, Krzakowski M, Misiak M

,Szczepanek K. Polskie Rekomendacje Żywienia Dojelitowego i Pozajelitowego w Onkologii — część II: żywienie drogą przewodu pokarmowego (żywienie dojelitowe). Onkologia w Praktyce Klinicznej 2013; 9, 6: 209–215.

Goldfinch B. Indications for nutritional therapy. Pharma Poland 1999; 55 (16):


Lyman B, Williams M, Sollazzo J. Enteral Feeding Set Handling Techniques. Nutrition in Clinical Practice 2017;32:193-200.

Pitts M.W, Burns C.N, Ogawa-Wong A.N, Kremer P, Berry M.J. Selenoproteins in Nervous System Development and Function. Biol. Trace Elem. Res 2014; 161(3): 231-245.

Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Biochim. Biophys. Acta 2013; 1830(5): 3289-3303.

Klecha B, Bukowska B. Selen w organizmie człowieka- charakterystyka pierwiastka i potencjalne zastosowanie terapeutyczne. Bromat. Chem. Toksykol

;XLIX (4):818-829.

Gromadzińska J, Reszka E, Bruzelius K, Wąsowicz W, Åkesson B. Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur. J. Clin. Nutr 2008; 47(2): 29-50.

Köhrle J, Jakob F, Contemprè B, Dumont JE: Selenium, the thyroid, and the endocrine system. Endocr Rev 2005; 26: 944-984.

Stranges S, Marshall JR, Natarajan R et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147: 217-223.

Ratajczak M, Gietka-Czernel M. Rola selenu w organizmie człowieka. Post N Med 2016;XXIX (12):929-933.

Salonen JT, Alfthan G, Pikkarainen J et al. Association between cardiovascular death and myocardial infarction in a matched pair longitudinal study. Lancet 1982; 2: 175-179.

Zagrodzki P. Selen, a układ odpornościowy. Postępy Hig Med. Dosw 2004;58:140-149.

Zagrodzki P, Kryczyk J. Znaczenie selenu w chorobie Hashimoto. Postępy Hig. Med 2014;68:1128-1137.

Bartosz G. Druga twarz tlenu. Wolne rodniki w przyrodzie. Wyd. I. Wydawnictwo Naukowe PWN. Warszawa 2008.



  • There are currently no refbacks.

Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski