Influence of phytopreparations on rat parodont state at experimental metabolic syndrome

I. P. Dvulit

Abstract


Aim: To investigate periodontoprotective action of 2 phytopreparations: husks of grapes meal and oak extract at the metabolic syndrome.

Methods: The metabolic syndrome was reproduced into rats by used high fat diet, dysbiosis and introduced cytostatic. The husks of grapes meal was introduced per os in dose 500 mg/kg every days and the oak extract was introduced in dose 2 ml/kg with drink water. The duration of experiment was 38 days. The activities of enzyme were determined in gum (elastase, urease, lysozyme, catalase) and in periodontal bone (alkaline and acid phosphatases). The content of protein and hyaluronic acid were determined into gum, and the content of calcium and protein were determined into bone.

Results: The levels of protein, hyaluronic acid, lysozyme, catalase were reduced into gum, but the levels of urease, elastase were increased at metabolic syndrome. The levels of alkaline phosphatase and content of calcium were reduced in bone but the level of acid phosphatase was increased at metabolic syndrome. Phytopreparations increased the levels of hyaluronic acid, lysozyme, catalase, but reduced levels of urease, elastase into gum, and the level of acid phosphatase into bone.

Conclusion: Phytopreparations has periodontoprotective action at the metabolic syndrome.


Keywords


metabolic syndrome, periodontum, dysbiosis, inflammation, phytopreparations

Full Text:

PDF

References


Makarenko O. A., Tsevbukh L. B., Levitsky A. P. The modern ideas about the meta-bolic syndrome development and his correction by bioflavonoids. Aktualnye problemy trans-portnoi meditsiny. 2015; 2(3(41-II): 24-32.

Tkachenko V. I., Bagro T. O., Vydyborec' N. V. [et al.]. The metabolic syndrome: di-agnostics and prophilaxis at family doctor practice. Liky Ukrai'ny. 2016; 1-2: 43-46.

Levitsky A. P., Glazunov O. А., Meladze I. N. Influence of quertulin on condition of parodont in rats with experimental metabolic syndrome. Journal Health Sciences. 2014; 4(11): 133-144.

Levitsky A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Kvertulin. Vitamin P, prebiotik, gepatoprotektor [“Querthulin”, Vitamin P, prebiotic, hepatoprotector].Оdеssа, KP OGT, 2012:20.

Meladze I. N., Tomilina T. V., Stupak E. P.. Parodont-protective effect of antidys-biotic drugs at the experimental metabolic syndrome. Visnyk mors'koi' medycyny. 2015; 2(67): 75-81.

Levitsky A. P., Makarenko O. A., Levchenko O. M. [et al.]. Bioflavonoidnye gepato-protektory [Bioflavonoid hepatoprotectors]. Odessa: KP OGT, 2014: 86.

TU U 15.8-19412998-004:2011 «Oak extract». Vysnovok MOZU № 05.03.02-06/88168 vid 01.09.2011

Den'ga O. V., Makarenko O. A., Tomilina T. V. [et al.]. The methods of experimental pathology of periodonte. In book: The Experimental stomatology. P. 1. The experimental models of Stomatological diseases (Levitskу A. P., Shnaider S. A.). Оdеssа, KP OGT, 2017: 68-102.

Goryachkovskiy A. M. Klinicheskaya biokhimiya v laboratornoy diagnostike [The clinical biochemistry in laboratorial diagnostics] [3rd ed.]. Odessa, Ekologiya, 2005: 616.

Entsiklopediya klinicheskikh laboratornykh testov [The encyclopedia of clinical la-boratoric tests]. Red. N. U. Tica. Moskva: Labinform, 1997: 128, 459-460.

Levitsky A. P., Denga O. V., Makarenko O. A. [et al.]. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti: metodicheskie rekomendatsii [Biochemical markers of inflammation of oral cavity tissue: method guidelines]. Оdеssа, KP OGT, 2010: 16.

Lowry O. N., Rosebrongt N. J., Porr A. L. [et al.]. Protein measurement soith Folin phenol reagent. J. Biol. Chem. 1951;.193: 265-275.

Asatiani V. S. Novye metody biokhimicheskoy fotometrii [The new methods in bio-chemical photometry]. Moskva, Nauka, 1965: 298.

Levitskiy A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Fermentativnyy metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov: metodicheskie rekomen-datsii [Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiot-ics: method guidelines]. Кiev, GFC, 2007: 22.

Levitsky A. P., Makarenko O. A., Denga O. V. [et al.]. Eksperimentalnye metody issledovaniya stimulyatorov osteogeneza: metodicheskie rekomendatsii [The experimental methods of the study of osteogenesis stimulators]. Kiev, GFK, 2005:50.

Levitsky A. P., Makarenko O. A., Khodakov I. V. [et al.]. The enzymatic method of the estimation of the state of osseous tissue. Оdеskiy medychnyy zhurnal. 2006; 3:17-21.

Lapach S. N., Chubenko A. V., Babich P. N. Statisticheskiye metody v medico-biologicheskikh issledovaniyakh s ispolzovaniem Excel [Statistical methods in medical and biological research by using Excel]. Kiev, Morion, 2000: 320.

Wiernsperger N. The liver function and cardio-metabolic syndrome. Diabet, ozhyrinnja, metabolichnyj syndrom. 2014; 1: 37-47.




DOI: http://dx.doi.org/10.5281/zenodo.1210281

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)