Evaluation of a renoprotective potential of organospecific peptides under the conditions of acute kidney injury of different etiology

T. S. Shchudrova, I. I. Zamorskii, O. P. Korotun


Acute kidney injury (AKI) is a clinical syndrome which incidence increases dramatically over the past years in both developing and developed countries. It is considered as an independent risk factor for mortality in critically ill patients as well as complicates the course of a significant number of diseases. Consequently, there is a great need for new effective renoprotective options. Our research was conducted to evaluate the renoprotective potential of organospecific peptides (peptide kidney complex, synthetic oligopeptides AED, EDL and AEDG) in comparison with antioxidant drug mexidol (emoxypine succinate) and pineal hormone melatonin. An integral criterion of renoprotective activity was a survival rate of animals under the conditions of AKI of different genesis: induced by ethylene glycol, cisplatin, gentamicin, rhabdomyolysis and ischemia-reperfusion. All of the studied peptides decreased mortality of animals, while the most significant protective effect was shown by peptide EDL, confirmed by 33.3% survival rate on the 5th day of ethylene glycol intoxication development and 100% survival on the other models of AKI. The least effective was peptide AED, as it prevented mortality only in animals with cisplatin-induced AKI. Obtained results show the renoprotective potential of organospecific peptides and give the background for their further study.


peptides, acute kidney injury, survival rate, renoprotection

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Case J, Khan S, Khalid R, Khan A. Epidemiology of Acute Kidney Injury in the Intensive Care Unit. Critical Care Research and Practice. 2013;2013:479730. doi:10.1155/2013/479730.

Chatzizisis YS, Misirli G, Hatzitolios AI, Giannoglou GD. The syndrome of rhabdomyolysis: complications and treatment. European Journal of Internal Medicine. 2008;19:568-574. doi:10.1016/j.ejim.2007.06.037

Dirkes S. Acute kidney injury: not just acute renal failure anymore? Critical Care Nurse. 2011;31(1):37-50.

Gansevoort RT, Correa-Rotter R, Hemmelgarn BR et al. Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention The Lancet. 2013;382(9889):339-52. doi: 10.1016/S0140-6736(13)60595-4.

Jammalamadaka D, Raissi S. Ethylene Glycol, Methanol and Isopropyl Alcohol Intoxication. The American Journal of the Medical Sciences. 2010;339(3):276-81. doi: 10.1097/MAJ.0b013e3181c94601.

Kilic U, Kilic E, Tuzcu Z et al. Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutrition & Metabolism. 2013;10:7. doi:10.1186/1743-7075-10-7.

Korrapati MC, Shaner BE, Schnellmann RG. Recovery from Glycerol-Induced Acute Kidney Injury Is Accelerated by Suramin. The Journal of Pharmacology and Experimental Therapeutics. 2012;341(1):126-136. doi:10.1124/jpet.111. 190249.

Lameire NH, Bagga A, Cruz D, De Maeseneer J. et al. Acute kidney injury: an increasing global concern. The Lancet. 2013;382(9887):170-9. doi: 10.1016/S0140-6736(13)60647-9

Li PK, Burdmann EA, Mehta RL. Acute kidney injury: Global health alert. Saudi Journal of Kidney Diseases and Transplantation. 2013;24:345-50.

Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney International. 2011;79(1):33-45. doi: 10.1038/ki.2010.337.

Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of cisplatin nephrotoxicity. Toxins (Basel). 2010;2(11):2490-2518. doi:10.3390/toxins 2112490.

Neves JB, Jorge S, Lopes JA Acute Kidney Injury: Epidemiology, Diagnosis, Prognosis, and Future Directions EMJ Nephrology. 2015;3(1):90-96.

Pal Singh A., Arunachalam M, Jaggi AS, et al. Animal models of acute renal failure. Pharmacological Report. 2012;(64):31-44.

Siew ED, Davenport A. The growth of acute kidney injury: a rising tide or just closer attention to detail? Kidney International. 2015;87(1):46-61. doi:10.1038/ki.2014.293.

Shtrygol SYu, Tovchyga OV, Koyro OO, Shchekina YeG. Novyye perspectivy v nephroprotekcii [New perspectives in nephroprotection]. Bukovinskiy medychnyy visnyk. 2012;16(3):35-37. (in Russian)

Zamorskii II, Shchudrova TS, Lin’kova NS et al. Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis. Bulletin of Experimental Biology and Medicine. 2017;163(3):389-393. doi: 10.1007/s10517-017-3811-1.

Zamorskii II, Shchudrova TS. Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides. Biophysics. 2014;59(5):834-836. doi: 10.1134/S0006350914050315.

Zamorskii II, Shchudrova TS, Lin’kova NS, Nichik TE, Khavinson VKh. Peptides restore functional state of the kidneys during cisplatin-induced acute renal failure. Bulletin of Experimental Biology and Medicine. 2015;159(6):736-739. doi: 10.1007/s10517-015-3062-y.

DOI: http://dx.doi.org/10.5281/zenodo.1188278


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