Email this article 
Hide
Show all
Correlative link ages between indices of bone metabolism and thyroid hormones in rats with periodontitis
Abstract
Introduction: It has been established that changes in the bone tissue of the jaw are present in all cases where there are at least small pathological inflammatory changes in the mucous membrane of the oral cavity. This suggests a significantly greater pathogenetic relationship between inflammatory changes in the mucosa and changes in the bone part of the periodontal disease. Despite a large number of studies, the molecular mechanisms of the influence of thyroid hormones on the bone metabolism have not been completely studied.
The aim of study: to clarify mechanisms of the periodontitis development in rats with thyroid dysfunction based on a comparative analysis of the correlations between the bone metabolism indices and the concentration of thyroid stimulating hormone, free thyroxine and free triiodothyronine.
Material and methods: Experimental studies were conducted on male, nonliner, white rats of around 4 months of age. The experimental animals were divided into the following groups: І – control animals; ІІ – animals with periodontitis; ІІІ – animals with periodontitis combined with hyperthyroidism; IV – animals with periodontitis combined with hypothyroidism. Total calcium, ionized calcium, phosphorus, osteocalcin concentration and activity of phosphatases were measured. Correlation analysis was performed between all the studied indices. Coefficient of linear correlation (r) and its fidelity (p) was calculated that was accordingly denoted in the tables (correlation matrices). The correlation coefficient was significant at p<0.05.
Results: The conducted correlative analysis shows that there are different interconnections between the indices of calcium-phosphorus metabolism, bone formation and bone resorption with free triiodothyronine, free thyroxine and thyroid stimulating hormone, in case of the experimental periodontitis combined with thyroid dysfunction. In animals with modelled periodontitis combined with hyperthyroidism, more correlative interactions with triiodothyronine, thyroxine and thyroid stimulating hormone were established compared to the rats of hypothyroid group.
Conclusions: Consequently, the thyroid dysfunction significantly affects the parameters of bone metabolism in case of an experimental periodontitis, which requires further research.
Keywords
Full Text:
PDFReferences
Avdieiev OV. Stupin aktyvnosti fosfataz pry eksperymentalnomu parodontyti ta za yoho korektsii [Stupin activity of phosphatases during experimental parodontitis and after correction]. Klinichna stomatolohiia, 2013; 3(4): 13-17. (in Ukrainian)
Shepelkevich AP, Leonova TA, Zhukovskaya OV, Suhodolova OI. Giperfunktsiya schitovidnoy zhelezyi i kostnyiy metabolizm [Hyperfunction of the thyroid gland and bone metabolism]. Meditsinskiy zhurnal, 2011; 1: 116-123. (in Ukrainian)
Korenevskaya NA, Gorodetskaya IV. Sostoyanie tkaney marginalnogo periodonta pri hronicheskom stresse zavisit ot tireoidnogo statusa organizma [The condition of the marginal periodontal tissues under chronic stress depends on the thyroid status of the organism]. Vestnik VGMU, 2010; 9 (1): 1-11. (in Russian)
Kutya SA. Vozrastnyie osobennosti sostoyaniya kaltsiy-fosfornogo metabolizma u kryis, podvergavshihsya deystviyu gravitatsionnyih peregruzok [Age features of the state of calcium-phosphorus metabolism in rats subjected to gravitational acceleration]. Ukrainskyi morfolohichnyi almanakh, 2009; 7 (4): 80-82. (in Ukrainian)
Masalova NN, Zaharenko RV. Sostoyanie fosforno-kaltsievogo obmena i kostnogo metabolizma v norme i pri narushenii funktsii schitovidnoy zhelezyi [The state of phosphorus-calcium metabolism and bone metabolism in norm and in violation of thyroid function]. Dalnevostochnyiy meditsinskiy zhurnal, 2009; 2: 122-125. (in Russian)
Moyseeva EH. Metabolycheskyi homeostaz y ymunnaia reaktyvnost orhanyzma v dynamyke vospalenyia v tkaniakh parodonta [Metabolic homeostasis and immune reactivity of the organism in the dynamics of inflammation in periodontal tissues]. Extended abstract of Doctor’s thesis. Moskva, 2008; 45. (in Russian)
Pobihun NH. Kaltsii-fosfornyi balans u shchuriv iz hipofunktsiieiu shchytopodibnoi zalozy pry fizychnomu navantazhenni, stresi ta yikh poiednanni [Calcium-Phosphorus balance in rats with hypothyroidism of the thyroid gland under physical activity, stress and their combination]. Extended abstract of PhD thesis. Ivano-Frankivsk, 2015; 20. (in Ukrainian)
Scherbich VM, Moskovskiy SN, Konev VP, Sulimov AF. Pokazateli kachestva kostnoy tkani chelyusti v skriningovoy diagnostike bolezney parodonta [Parameters of jaw bone tissue quality in screening diagnostics of periodontal diseases]. Saratovskiy nauchno-meditsinskiy zhurnal, 2009; 5 (4): 588-590. (in Russian)
Ratushnenko VO. Funktsionalna rol tiol-dysulfidnoi systemy pry eksperymentalnomu hipo- i hipertyreozi [Functional role of thiol-disulphide system in experimental hypo- and hyperthyroidism]. Odeskyi medychnyi zhurnal, 2010; 2 (118): 17-20. (in Ukrainian)
Uspenskaya OA, Kachesova ES. Izmeneniya biohimicheskih pokazateley krovi pri lechenii byistroprogressiruyuschego parodontita [Changes in biochemical parameters of blood in the treatment of fast-progressive periodontitis]. Problemyi stomatologii, 2017; 13 (2): 33-38. (in Russian)
Sutaeva TR, Minkailova SR, Shamov IM, Omarov OG. Hronicheskiy generalizovannyiy parodontit u bolnyih endemicheskim zobom [Chronic generalized periodontitis in patients with endemic goiter]. Vestnik novyih meditsinskih tehnologiy, 2012; ХIХ (3): 46-47. (in Russian)
Cardoso LF, Maciel LMZ, de Paula FJA. The multiple effects of thyroid disorders on bone and mineral metabolism. Arq Bras Endocrinol Metab. 2014; 58 (5): 452-463.
Dolidze NM, Kezeli DD, Kilasoniya LO. Changes in intra- and extracellular Ca2+ concentration and prostaglandin E2 synthesis in osteoblasts of the femoral bone in experimental hyper- and hypothyroidism. Bull Exp Biol Med. 2007; 144: 17-20.
Kalajzic Z, Peluso ЕВ, Utreja A, et al. Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement. Angle Orthod. 2014; 84: 297-303.
European convention for the protection of vertebrate animals used for experimental and other scientific purposes. – Council of Europe. Strasbourg, 1986; 123: 52.
Gorka J, Taylor-Gjevre R, Arnason Т. Metabolic and clinical consequences of hyperthyroidism on bone density. Int J Endocrinol. 2013; 638727.
Schwarz C, Leichtle AB, Arampatzis S, et al. Thyroid function and serum electrolytes: does an association really exist? Swiss. Med.Wkly. 2012; 142: 136-139.
Tuchendler D, Bolanowski М. The influence of thyroid dysfunction on bone metabolism. Thyroid Research. 2014; 7: 12.
Tsai J, Janson А, Bucht Е, et al. Weak evidence of thyrotropin receptors in primary cultures of human osteoblast-like cells. Calcif Tissue Int. 2004; 74: 486-491.
DOI: http://dx.doi.org/10.5281/zenodo.1117074
Refbacks
- There are currently no refbacks.
Copyright (c) 2017 © The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Education, Health and Sport formerly Journal of Health Sciences
Declaration on the original version.
Editors indicates that the main version of the magazine is to issue a "electronic".
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X
Archives 2011 - 2014
PBN 2011 - 2014
https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616
POL-index 2011 - 2014
https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655
BASE 2011 - 2014
http://elibrary.ru/contents.asp?titleid=37467
http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska
US NLM = 101679844
101679844 - NLM Catalog Result - NCBI
https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844
Find a library that holds this journal: http://worldcat.org/issn/23918306
Journal Language(s): English
PBN Poland
https://pbn.nauka.gov.pl/sedno-webapp/journals/49068
POL-index
https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4
BASE
Redaction, Publisher and Editorial Office
Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X
The journal has been approved for inclusion in ERIH PLUS.
The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984
SIC Science citation index (calculated on the basis of TCI and Page Rank) 0
Russian Impact factor 0.16
Indexed in Index Copernicus Journals Master List.
http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html
ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 2011: 5.48
The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.
Website: www.infobaseindex.com
Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)
Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)
is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.
Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467
Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski
(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)