The comparative effects of quertulin and adrenoblocators oral geles on the biochemical indices of rat serum after common action adrenaline and lincomycin

A. V. Borisenko, O. V. Kononova, A. P. Levitsky


Aim: To compare action of quertulin and adrenoblocators oral geles on the biochemical indices of rat serum after common action adrenaline and lincomycin.

Methods: Adrenaline stress was made by oral application of gel with adrenalin in dose 0,36 mg/kg during 10 days. Lincomycin was introduced with drinking water in dose 60 mg/kg. The gel of quertulin was introduced by application in dose 20,34 mg/kg and the gel of adrenoblocators (zocson + nicergolin and sibason) by application in dose 0,6 mg/kg. Conents of glucose, triglycerides, total cholesterine and malonic dialdehide (MDA), the activities of urease, lysozyme, elastase and catalase were determined into serum.

Results: Both geles no influenced on the serum conten glucose and triglycerides, but raised the content cholesterine. The adrenoblocator gel reduced activity urease and content MDA, but raised activity catalase. The quertulin gel reduced the activity elastase and raised the activity catalase.

Conclusion: Oral application of gel with adrenoblocators made antidysbiotic action more then quertulyne, but yielded in antiinflammation and antioxidative actions to quertulyne after common introduce adrenaline and lincomycin.


adrenaline, antibiotic, adrenoblocator, quercetin, dysbiosis, inflammation, antioxidant

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Kononova O. V. The influence of lincomycin upon the state of periodontium in rats with adrenal stress. Visnyk stomatologii. 2016; 3(96): 26-28.

Levitsky A. P., Volyanskiy Yu. L., Skidan K. V. Prebiotiki I problema disbacterioza [Prebiotics and the problem of dysbacteriosis]. Kharkov, EDENA, 2008:100.

Levitsky A. P. Human microbiome and health. Biulleten ХVI chtenii im. V. V. Podvysotskogo, 18-19 maia 2017. – Odessa, 2017: 191-193.

Levitsky A. P. The use of antidysbiotic preparations in dentistry. Visnyk stomatologii. 2014; 4(89): 89-92.

Levitsky A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Kvertulin. Vitamin P, prebiotik, gepatoprotektor [“Querthulin”, Vitamin P, prebiotic, hepatoprotector].Оdеssа, KP OGT, 2012: 20.

Kononova O. V., Borisenko A. V., Levitsky A. P. The influence of oral gels of quertulin and adrenergic blockers upon the state of periodontium in rats with adrenalin stress. Visnyk stomatologii. 2016; 4(97): 8-11.

Goryachkovskiy A. M. Klinicheskaya biokhimiya v laboratornoy diagnostike [The clinical biochemistry in laboratorial diagnostics] [3rd ed.]. Odessa, Ekologiya, 2005: 616.

Entsiklopediya klinicheskikh laboratornykh testov [The encyclopedia of clinical laboratoric tests]. Red. N. U. Tica. Moskva: Labinform, 1997: 128, 459-460.

Levitsky A. P., Denga O. V., Makarenko O. A., Dem’yanenko S. A., Rossachanova L. N., Knava O. E. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti: metodicheskie rekomendatsii [Biochemical markers of inflammation of oral cavity tissue: method guidelines]. Оdеssа, KP OGT, 2010: 16.

Levitskiy A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Fermentativnyy metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov: metodicheskie rekomendatsii [Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiotics: method guidelines]. Кiev, GFC, 2007: 22.

Truhacheva N. V. Matematicheskaja statistika v mediko-biologicheskih issledovanijah s primeneniem paketa Statistica [Mathematical Statistics in biomedical research using application package Statistica]. Moskva, GJeOTAR-Media, 2012: 379.

Guarner C., Soriano G. Bacterial translocation and its consequence in patients cirrhosis. Eur. J. Gastroenterol. Hepatol. 2005; 17(1): 27-31.



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