The occurrence of skin lesions in patients with androgenization syndromes including the analysis of the results of hormonal tests

Mirela Niedzielska, Artur Kotwas, Paulina Zabielska, Katarzyna Korabiusz, Agata Wawryków, Inga Janik, Anna Fabian- Danielewska

Abstract


The androgenisation syndrome in women with endocrine disease is a major interdisciplinary problem. Based on the analysis of the literature, the problem was defined and the most important diseases resulting from the excess of androgens were discussed. Acne is the most commonly diagnosed skin disease in teens and young adults. It is often caused by an excess of androgens or skin hypersensitivity to normal levels.

 

The aim of the study was to analyze the effect of androgens on skin lesions in androgenisation syndromes.

 

Material and methodology: The analysis concerned the results of hormonal studies included

In the medical records 150 young women aged 16 to 36 years. The study group (group A) was 100 patients diagnosed with ovarian androgen syndrome. The control group consisted of 50 healthy women who did not meet the criteria of the study group.

 

Results: It was found that the majority of them were juvenile patients,

In addition, elevated androgens: SHBG (p = 0.016), DHEA-S (p <0.000), testosterone (p <0.000) and androstenedione (p = 0.007) were compared with those of the group control. There was a significant correlation (r = -0.420; p <0.000) between testosterone and androstenedione, SHBG and DHEA-S (r = -0.391; p <0.000), SHBG a (r = -0.272; p <0.009).

 

Conclusions: Among the most important hormones that can affect anogenesis are androgens, therefore a detailed understanding of the pathology associated with androgenisation is a must for gynecologists, dermatologists, endocrinologists, family physicians, pediatricians and cosmetologists. Youth acne is a significant clinical marker of androgenisation syndrome and can not be considered a temporary symptom of puberty in adolescents. Cosmetic procedures applied to the skin with acne may be ineffective without prior hormonal diagnosis.


Keywords


androgenization syndrome, hormonal tests

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DOI: http://dx.doi.org/10.5281/zenodo.885405

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