Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer

P. V. Tkachenko, I. I. Yakovtcova, O. V. Dolgaya, I. V. Ivakhno

Abstract


Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p <0.05 and p <0.01, respectively). An inverse dependence between the reaction of vimentin and E-cadherin (p <0.05) and their correlation withTGFβ (p <0.05) was detected. Conclusion: community of the molecular-biological manifestations of the epithelial-mesenchymal transformation in prostate gland cancer and involvement of TGFβ into its process has been proved. Epithelial-mesenchymal transformation maybe a prognostic criterionof the disease.


Keywords


prostate gland cancer, vimentin, E-cadherin, TGFβ, epithelial-mesenchymal transformation

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