Some novel ways of gastric cancer patients treatment personification

S. I. Kirkilevsky, A. G. Lurín, V. G. Dubinina, O. V. Lukyanchuk, A. A. Mashukov, A. A. Bilenko, A. N. Zgura, D. N. Osadchy, V. E. Maksimovskiy

Abstract


In this paper the authors perform the analysis of molecular and morphological factors influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2, Ki-67. Measured role in the survival such factors as the degree of differentiation of primary gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as a comparison of the areas under the curves of survival.


Keywords


gastric cancer (GC), lymph node dissection, multiorgan resection, immunohistochemistry, genetic classification

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References


Amato M, Perrone G, Righi D, Pellegrini C, Rabitti C, Di Matteo F, Crucitti P, Caputo D, Coppola R, Tonini G, Santini D, Onetti Muda A. HER2 Status in Gastric Cancer: Comparison between Primary and Distant Metastatic Disease.Pathol Oncol Res. 2016 Jun 30. PMID: 27363700.

Huang G, Chen S, Wang D, Wang R, Lin L, Chen S, Wang L, Huang Q. High Ki67 Expression has Prognostic Value in Surgically-Resected T3 Gastric Adenocarcinoma.Clin Lab. 2016; 62 (1-2): 141-53. PMID: 27012044.

Kanayama K, Imai H, Yoneda M, Hirokawa YS, Shiraishi T. Significant intratumoral heterogeneity of human epidermal growth factor receptor 2 status in gastric cancer: A comparative study of immunohistochemistry, FISH, and dual-color in situ hybridization.Cancer Sci. 2016 Apr; 107 (4): 536-42. doi: 10.1111 / cas.12886. Epub 2016 Feb 19. PMID: 26752196.

Chen T, Xu XY, Zhou PH. Emerging molecular classifications and therapeutic implications for gastric cancer.Chin J Cancer. 2016 May 27; 35 (1): 49. doi: 10.1186 / s40880-016-0111-5. Review. PMID: 27233623.

Stahl P, Seeschaaf C, Lebok P, Kutup A, Bockhorn M, Izbicki JR, et al. Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer. BMC Gastroenterol. 2015; 15: 7. doi: 10.1186 / s12876-015-0231-4.

Zhang W. TCGA divides gastric cancer into four molecular subtypes: implications for individualized therapeutics. Chin J Cancer. 2014; 33 (10): 469-470.

Murphy G, Pfeiffer R, Camargo MC, Rabkin CS. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology. 2009; 137 (3): 824-833.

Burke AP, Yen TS, Shekitka KM, Sobin LH. Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod Pathol. 1990; 3 (3): 377-380.

Cidon EU, Ellis SG, Inam Y, Adeleke S, Zarif S, Geldart T. Molecular targeted agents for gastric cancer: a step forward towards personalized therapy. Cancers (Basel) 2013; 5 (1): 64-91. doi: 10.3390 / cancers5010064.

Jong Gwang Kim. Molecular targeted therapy for advanced gastric cancer. Korean J Intern Med. 2013 Mar; 28 (2): 149-155. PMCID: PMC3604602.

Tsai HL, Lin CH, Huang CW, Yang IP, Yeh YS, Hsu WH, Wu JY, Kuo CH, Tseng FY, Wang JY. Decreased peritherapeutic VEGF expression could be a predictor of responsiveness to first-line FOLFIRI plus bevacizumab in mCRC patients. Int J Clin Exp Pathol. 2015 Feb 1; 8 (2): 1900-10.

Weiguo Cao, Rong Fan, Weiping Yang, Yunlin Wu. VEGF-C expression is associated with the poor survival in gastric cancer tissue. Tumor Biology. April 2014, Volume 35, Issue 4, pp 3377-3383.

Hong-Feng Gou, Xin-Chuan Chen, Jiang Zhu, Ming Jiang, Yu Yang, Dan Cao, and Mei Hou. Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications. J Exp Clin Cancer Res. in 2011; 30 (1): 14. PMCID: PMC3037339 (full text).

Makoto Ishikawa, Joji Kitayama, Shinsuke Kazama and Hirokazu Nagawa. Expression of Vascular Endothelial Growth Factor C and D (VEGF-C and -D) is an Important Risk Factor for Lymphatic Metastasis in Undifferentiated Early Gastric Carcinoma. Japanese Journal of Clinical Oncology. Volume 33, Issue 1. Pp. 21-27 (full text).

Yutaka Yonemura, Yoshio Endo, Kayoko Tabata, Taiichi Kawamura, Hyo-Yung Yun, Etsurou Bandou, Takuma Sasaki, Masahiro Miura. Role of VEGF-C and VEGF-D in lymphangiogenesis in gastric cancer. International Journal of Clinical Oncology. October 2005, Volume 10, Issue 5, pp 318-327.

Julian Ananiev, Maya Gulubova, Irena Manolova, Georgi Tchernev. Prognostic significance of HER2 / neu expression in gastric cancer. Article (PDF Available) in Wiener klinische Wochenschrift 123 (13-14): 450-4 • July 2011 (full text).

Jan Trøst Jørgensen, Maria Hersom. HER2 as a Prognostic Marker in Gastric Cancer - A Systematic Analysis of Data from the Literature. J Cancer 2012; 3: 137-144. doi: 10.7150 / jca.4090 (full text).

C. Gravalos; A. Jimeno. HER2 in Gastric Cancer: A New Prognostic Factor and a Novel Therapeutic Target. Ann Oncol. 2008; 19 (9): 1523-1529 (full text).

Josef Rüschoff, Wedad Hanna, Michael Bilous, Manfred Hofmann, Robert Y Osamura, Frédérique Penault-Llorca, Marc van de Vijver and Giuseppe Viale. HER2 testing in gastric cancer: a practical approach. Modern Pathology (2012) 25, 637-650.

Sheffield BS1, Garratt J, Kalloger SE, Li-Chang HH, Torlakovic EE, Gilks CB, Schaeffer DF. HER2 / neu testing in gastric cancer by immunohistochemistry: assessment of interlaboratory variation. Arch Pathol Lab Med. 2014 Nov; 138 (11): 1495-502. doi: 10.5858 / arpa.2013-0604-OA.

Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer Association. Gastric Cancer (1998) 1: 10-24

Alessandro Lugli, Inti Zlobec, Gad Singer, Andrea Kopp Lugli, Luigi M Terracciano and Robert M Genta *. Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology. Nature Clinical Practice Gastroenterology & Hepatology (2007) 4, 52-57.

Kawata S, Yashima K, Yamamoto S, Sasaki S, Takeda Y, Hayashi A, Matsumoto K, Kawaguchi K, Harada K, Murawaki Y. AID (activation-induced cytidine deaminase), p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa. Oncol Lett. 2015 Aug; 10 (2): 737-743.

Terashima M, Kitada K, Ochiai A, et al. ACTS-GC Group. Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II / III gastric cancer. Clin Cancer Res. 2012; 18: 5992-6000. doi: 10.1158 / 1078-0432.CCR-12-1318. [PubMed] [Cross Ref]

Kim JY, Jeon TJ, Bae BN, et al. The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma. APMIS. 2013; 121: 95-104. doi: 10.1111 / j.1600-0463.2012.02942.x. [PubMed] [Cross Ref]

Sheffield Brandon, Garratt J, Kalloger SE, Li-Chang HH, Torlakovic EE, Gilks CB, Schaeffer DF. HER2 / neu testing in gastric cancer by immunohistochemistry: assessment of interlaboratory variation. Arch Pathol Lab Med. 2014 Nov; 138 (11): 1495-502. doi: 10.5858 / arpa.2013-0604-OA.




DOI: http://dx.doi.org/10.5281/zenodo.801825

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