Metabolites content of stable forms of nitric oxide in the lungs of guinea pigs with experimental allergic alveolitis in different periods of its formation

M. S. Reheda, B. Ya. Melekh, M. O. Kachmarska


In this paper was found that the conditions for the development of experimental allergic alveolitis on the 44-th day increased the activity of inducible nitric oxide synthase and stable forms of nitric oxide metabolites. These changes were probably related to proinflammatory properties of nitric oxide and the development of adequate immune response. Significant increase of nitric oxide metabolites can be used as a diagnostic method of development of allergic alveolitis by determining the concentration of these metabolites in exhaled air.


nitric oxide, L-arginine, NO-synthase, experimental allergic alveolitis

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