Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy

Krystyna Stencel-Gabriel, Joanna Kula-Gradzik, Łukasz Parszewski, Anna Majda

Abstract


Introduction

Study in which we found a significant and specific alteration of eotaxins-3  in active EoE childrens with food allergy.

Aim

The aim of the study was to identity eotaxin-3 that correlated with activity of EoE as measurmed by esophageal eosinophilia  and response to treatment by using elimination  diet  in children group with food allergy in the course of EoE.

Material and methods

Five childrens ranging in age from 12 to 18 years with EoE and food allergy was studied for up to 12 weeks of used eliminate food to which the children are sensitized. Biomarker (eotaxin-3 / CCL26) in serum were analyzed as to their use as a noninvasive biomarker for the diagnosis and assessment of EoE disease status.

Results

Eotaxin-3 levels correlated significantly with all investigated clinical parameters: blood eosinophils levels ( r=0,80,p<0,01), eosinophils in thissue biopsy ( r=0,66, p<0,01) and IgE levels (r=0,34,p<0,05) from EoE patients.

Conclusions

Eotaxin-3 might  constitute a pathogenic player in tissue eosinophilia and subsequent esophagus damage, and a biomarker for disease activity and interesting therapeutic target in EoE.


Keywords


eotaxin-3/CCL26, children, food allergy, serum, eosinophilic esophagitis EoE

Full Text:

PDF

References


Liacouras CA, Furuta GT, Hiran I et al 2011. Eosinophilic esophagitis: updated consensus recomendations for children and adults. J Allergy Clin Immunol 128:3-20.

Dellon ES, Jensen ET, Martin CF et al.2014. Prevelance of eosinophilic esophagitis in the United States .Clinic Gastroentorol Hepatol 12:589-596.

Dellon ES, Erichsen R, Baron JA et al .2015. The increasing incidence and prevalence of eosinophilic esophagitis outpaces changes in endoscopic and biopsy practice: national population-based estimates in Denmark. Aliment Pharmacol Ther 41:662-670.

Noel RJ, Putnam PE, Rothenberg ME. 2004. Eosinophilic esophagitis. N Engl J Med 351:940-941.

Sperger JM, Brown-Whitehorn TF, Cianfereroni A et al. 2012. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 130: 461-467.

Lucendo AJ, Arias A, Gonzalez-Cervera J et al. 2013. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol .131:797-804.

Blanchard C. Stucke EM, Rodriquez -Jimenez B. 2011: A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin. Immunol, 127 (1)208-17.

Kitamura M.,Suzuki N, Imai T et al.1999, molecular cloning of a novel human CC chemokine ( eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol chem :274:27975-27980.

Virchow JC, 2014, Eosiniphilic esophagitis: asthma of the esophagis; 32(1-2):54-60.

Blanchard C., Wang N.,Stringer K.F. et al . 2006, Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis .J Clin Invest. Feb(1);116(2);536-547.

Foruta GT, Liacuoras C, Collins MH et al 2007: Eosinopgilic esophagitis in children and adults: a systematic review and consensws and recommendations for diagnosis and treatment.Gastroenterology; 133:1342-1363.

Markowitz E, Spergel M, Rowe PC et al.: 2003: Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterology :109;1503-1512.

Bhwardwag N.Ghaffari G 2012: Biomarkers for eosinophilic esophagitis: a review. Ann Allergy Asthma Immunol;109;155-159.

Dellon ES Chen X Miller CR et al. 2012; Diagnosis utility of major basis protein, eotaxin-3 and and leukotriene enzyme staining in eosinophilic esophagitis. Am J Gastroenterol; 107;1503-1511.

Rhattacharya B, Caristen J, Sabo E et al 2007; Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease; 38 :1744-1783.

Subbraro G, Rosenman MB, Ohnuki L et all. 2011. Exploring potential noninvasive biomarkers in Eosinophilic Esophagitis in children JPGN;53:651-568.

Venkateshaiah SU, Manohar M, Verma A et al; 2016; Possible noninvasive biomarker of eosinophilic esophagitis: clinic and experimental evidence : Gastroenterology; 10 : 688-692.

Kaplan AP.2001; Chemokines, chemokines receptors and allergy: Int Arch Allergy Immunol 124: 423-31.

Ravenberg AJ, Riociardolo FL, Schadewijk A et al. 2005; Eotaxin-9 and eotaxin-3 expression is associated with persistant eosinophilic bronchial inflamation in patients with asthma after allergen challange. J Allergy Clin immunol; 115:776-85.

Akei HS, Mishra A, Blanhard C et al. 2006. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol.

Straumann A, Bauer M,Fischer B et al, 2001: Idiopathic eosinophilic esophagitis is associated with a T-helper 2-type allergic inflamatory reponse. J Allergy Clin Immunol: 108:954-961 118:1054-1059.

Kagalwalla AF, Shah A, Li BU et al. 2011: Identification of specific foods responsible for inflamation in children with eosinophilic esophagitis succesfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr 53:145-140.

Spergel JM. Brown-Witchorn TF, Beasolei JL: 2009: 14 Years of eosinophilic esophagitis clinical features and prognosis. 48:30-36.

Rothenberg SJ, Kondrashov V, Manalo M, et al 2001: Seasonal variation in bone lead contribution to blood lead during pregnancy. Environ Res.;85:191–194.

Mishra A, Hogan SP, Brandt EB et al.2001.An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest .107:83-90.

Mishra A, Hogan SP, Brandt EB 2002. Il-5 promotes eosinophil trafficking to the esophagus. J Immunol. 168:2464-2469.

Mishra A, Rothenberg ME.2003: Intratracheal Il-13 induces eosinophilic esophagitis by an Il-5, eotaxin-1 and STAT6 dependent mechanism. Gastroenterology, 125:1419-1427.

Flood-Page PT, Marizies-Gow AN, Kay AB, 2003; Eosinophils role remains uncertain as anti-interleukin-5 only partially deletes numbers in in asthmatic airway Am J Respi Crit Care Med : 167;199-204.

Straumann A, Bauer M, Fisher B et al. 2001, Idiopatic eosinophilic esophagitis is associated with a T(H)2-type allergic inflamatory response. J. Allergy Clin.Immunol.,108:954-962.

Schmid- Grendelmeler P et al. 2002; Eosinophils express functional Il-13 in eosinophilic inflamatory disease. J. Immunol.169:1021-1027 31.

Stein ML, Collins MH, Vilanuava JM et al.2006: Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis . JAllergy Clin Immunol :118:1312-9.

Flood-Page PT, Marizies-Gow AN, Kay AB, 2003; Eosinophils role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am J Respi Crit Care Med: 167;199-204.

Gerard C, Rollons BJ.2001: Chemokines and disease. Nat. Immunol; 2: 108-115.

Rankin SM, Conroy DM, Williams TJ: 2000, Eotaxin and eosinophilic recruitment: implications for human disease, Mol.Med.Today, 6:20-27.




DOI: http://dx.doi.org/10.5281/zenodo.569330

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 © The Author (s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Because of the parallel version of the magazine publishing traditional (paper) and of electronic (online), Editors indicates that the main version of the magazine is to issue a "electronic".

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

 

Dekłaracja.

Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.

Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

ISSN 2391-8306

formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

 

 

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

 

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1


http://elibrary.ru/contents.asp?titleid=37467


http://journal.rsw.edu.pl/index.php/JHS/issue/archive

 

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7



 Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, EBSCO, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

NLM Logo

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

 

 

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 


 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

 

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

 

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

 

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy

Institute of Physical Education
Kazimierz Wielki University in Bydgoszcz, Poland

85-091 Bydgoszcz ul. Sportowa 2 Tel. +48 52 32 31 707 www.ukw.edu.pl

Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy

 

 

http://ojs.ukw.edu.pl/index.php/johs

 

 Open Access

ISSN 2391-8306

formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 -2014

PBN

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

 

 

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

 

 

BASE

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1


http://journal.rsw.edu.pl/index.php/JHS/issue/archive

  The formerly journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1089 (31.12.2014). 

The formerly journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1107 (17.12.2013). 

 The journal has had 4 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 683 (21.12.2012).


The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at
https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

 

 

SIC Science citation index (calculated on the basis of TCI and Page Rank)0
Russian Impact factor
0.16




Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2016 = 84.69

ICV 2015:93.34

ICV 2014: 89.51 Standardized Value: 8.27


ICV 2013: 7.32

 ICV 2012: 6.41

ICV 2011: 5.48

 

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website:  www.infobaseindex.com


Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Federacja Bibliotek Cyfrowych

 

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)



POPULAR ARTICLES

 

»EFFECTS OF TRANSCRANIAL ELECTROANALGESIA ON CONDITION OF CEREBRAL HEMODYNAMICS IN PATIENTS WITH THE SYNDROME OF VEGETATIVE DYSTONIA DIFFERENT GENESIS. Влияние транскраниальной электроанальгезии на состояние церебральной гемодинамики у больных с синдромом
52389 views since: 2013-06-15
»ROLE OF BRAINSTEM WITHIN HUMAN BODY SYSTEMS – COMPUTATIONAL APPROACH
27276 views since: 2012-01-19
»ASSESSMENT OF THE PNF METHOD INFLUENCE ON GAIT PARAMETERS IMPROVEMENT IN PERSONS WITH CEREBRAL PALSY
23692 views since: 2012-01-04
»THE INFLUENCE OF PACLITAXEL TREATMENT ON SELECTED BIOCHEMICAL AND MORPHOLOGICAL BLOOD PARAMETERS IN PATIENTS DIAGNOSED WITH BREAST CANCER
21624 views since: 2011-08-21
»Efficiency of prevention-targeted curriculum in the correction of children’s physical condition and dynamics of their mental activity during physical exercising
16459 views since: 2014-10-31
»FUZZY ONTOLOGICAL KNOWLEDGE REPRESENTATION FOR THE TRAINING OF MEDICAL TERMINOLOGY
12679 views since: 2013-02-24
»ECLECTIC VS. SPECIFIC APPROACH WITHIN CONTEMPORARY NEUROLOGICAL PHYSIOTHERAPY
12377 views since: 2012-01-30
»BIOFEEDBACK AS THE ELEMENT OF THE NEUROREHABILITATION
11278 views since: 2012-01-30
»PATHOMORPHOLOGICAL CHANGES ACUTE LUNG INJURY
8763 views since: 2012-05-02
»EFFECT OF AEROBIC TRAINING ON THE HEALTH OF WOMEN FREQUENTING TO FITNESS CLUBS. Wpływ treningu aerobowego na zdrowie kobiet uczęszczających do klubów fitness
7957 views since: 2013-06-06