Fine needle biopsy in differential diagnosis of nodular goiter with autoimmune thyroiditis and differentiated thyroid cancers

M. I. Sheremet, L. P. Sydorchuk, V. O. Shidlovskyi, A. D. Bedenyuk, A. I. Popovych, O. V. Lazaruk

Abstract


We examined 75 women with nodular NGAIT and 12 patients with differentiated thyroid cancer during 2015-2016. We have carried out an immunohistochemical study by means of monoclonal antibodies against Fas, FasL, Bcl-2, P53 and Ki67 antigens using the thyroid gland puncture material.  

Thus, compared with known methods of differential diagnosis, the proposed study allows for preoperative stage, with a high probability differentiate NGAIT of DTC, by examining extracts from tissues of the thyroid gland, which, in turn, said the volume of surgery and treatment program.

            Abbreviations: NGAIT - nodular goiter combined with autoimmune thyroiditis, TG – thyroid gland, PCE – preoperative cytological examination, DTC- differentiated thyroid cancer.


Keywords


nodular goiter with autoimmune thyroiditis, fine needle biopsy, apoptosis, proliferation, thyroid gland, differentiated thyroid cancer

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References


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DOI: http://dx.doi.org/10.5281/zenodo.569989

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