THE INVESTIGATION OF GENE POLYMORPHISM β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA

N. V. Banadyha, S. B. Voloshyn

Abstract


Banadyha N. V., Voloshyn S. B. The investigation of gene polymorphism β2 - adrenoceptors in children with bronchial asthma. Journal of Education, Health and Sport. 2015;5(12):417-423. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35565

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A417-423

http://pbn.nauka.gov.pl/works/683080

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive

 

Deklaracja.

Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.

Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).

© The Author (s) 2015;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 10.11.2015. Revised 15.12.2015. Accepted: 17.12.2015.

 

THE INVESTIGATION OF GENE POLYMORPHISM

β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA

 

N. V. Banadyha, S. B. Voloshyn

 

Department of Pediatrics of Education-Research Instituteof Postgraduate training of the I.Ya. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine

 

Abstract

 

Given the importance of genetic factors in causing bronchial asthma (BA), should be noted that according to some researchers it stands on the importance of the role of adverse environmental factors and a lifestyle. Genetic factors contribute to human health by 40%, in the case of BA - in 60% of cases it is due to hereditary.

Objective: to analyze the frequency of polymorphic loci associations rs 1042713 (Arg16Gly) of  ADRβ2  gene in children with BA.

Materials and Methods. In-depth clinical examination using the special methods of investigation,  conducted to 62 children suffering from BA, older than 5 years.  

The results of investigation. As a result of depth collection of anamnesis, it was revealed that in 73,68% of patients the anamnesis was unburdened. Mostly the family inheritance depends on mother health  (57,14%), regardless of the severity of BA. Іt  was found that in both types of inheritance (paternal and maternal) dominated genotype Arg16Gly (respectively: 58,33% and 60,00%). However, genotype Arg16Arg was observed in individual patients and in the case of intermittent disease. In case of allergen-induced and virus-induced phenotypes the genotype Arg16Gly (respectively: 44,70%; 58,30%) was more often diagnosed. Among the examined patients, BA manifested at the early age in 18 children (33,96%) in preschool age in 17 children (32,08%), and in a primary school in 18 children (33,96%). The early debut of disease associated with genotype Arg16Gly manifested at the early age in  66,67% of children and in preschool age – in 58,82%, while late manifestation observed in children with genotype Gly16Gly. It was clarified that intermittent flow associated with two genotypes: Arg16Gly (47,37%) and  Gly16Gly (42,11%) The persistent mild course of BA replied to genotype Gly16Gly (64,71%), but with moderate persistent - to Arg16Gly (57,69%). Found that girls often associated with asthma genotype Gly16Gly (56,52%) and Arg16Gly (39,13%) while the boys with genotype Arg16Gly (53,84%), less with Gly16Gly (38,89%).

Conclusions. When treating the patient, the established differences in allele polymorphisms gene ADRβ2, regarding the age and gender,  should be taken into account.

 

Keywords: children, bronchial asthma, β2 – adrenoceptors, polymorphism of the gene.


Keywords


children, bronchial asthma, β2 – adrenoceptors, polymorphism of the gene.

Full Text:

PDF

References


Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroidtreated asthmatic patients taking frequent albuterol or salmeterol / [K. Basu, C.N. Palmer, R. Tavendale et al.] // J. Allergy Clin. Immunol. – 2009. – Vol. 124, № 6. – P. 1188-1194.

Agache I. Asthma risk factors and phenotypes in children and in adults with seasonal allergic rhinitis/ I. Agache, C. Ciobanu // J. All. Clin. Immunol. – 2010. – Vol. 125. – P.2

Association of adrenergic receptor gena polymorphism with adolescent obesity in Taiwan / [Y.C. Chon, C. N. Tsai, Y.S. Lee, J.S. Pei] // Pediatrics international. – 2012. – Vol.1., №54. – P.111-116.

Association of beta2-adrenergic receptor polymorphisms with severe asthma / [J.W. Holloway, P.R. Dunbar, G.A. Riley et al.] // Clin. Exp. Allergy. – 2009. – Vol. 30. – P.1097-1103.

Different inflammatory phenotypes in adult and children with acute asthma / [F. Wang, X.Y. He, K.J. Baines et al] // Eur. Respir. J. — 2011. — V. 57. — P. 643–648.

Genetic polymorphism and risk of recurrent wheezing in pediatric age / [S. Esposito, V. Ierordi, C. Doleno et al.] // Pulmonary Medicine. – 2014. – №14. – P.162.

Hizawa N. Beta-2 adrenergic receptor genetic polymorphisms and asthma / N. Hizawa // J. Clin. Pharm. Ther. – 2009. – Vol. 34, № 6. – P. 631-643.

Holloway J.W. Genetics of allergic disease / J.W. Holloway, I.A. Yang, S.T. Holgate // J. Allergy Clin Immunol. – 2010. – Vol. 125, №2. – Р. 81–94.

March M.E. Genetic polymorphisms and associated susceptibility to asthma / M. March, Р. Sleiman, Н. Hakonarson // Int. J. Gen. Med. – 2013. – Vol. 6. – P. 253-265.

Meyers D.F. Genetic of asthma and allergy: What have we learned? / D.F. Meyers // G.Allergy Clin. Immunol. – 2010. – Vol. 126. – P. 439-446.

The association between the IL-4, ADRβ2 and ADAM 33 gene polymorphisms and asthma in the Taiwanese population / [C.H. Chiang, M.W. Lin, M.Y. Chung, U.C. Yang] // J. Chin. Med. Assoc. – 2012. – Vol. 75, № 12. – P. 635-643.

Tachyphylaxis to β2-agonists in Spanish asthmatic patients could be modulated by β2-adrenoceptor gene polymorphisms / [J. Jose Telleríaa, A. Blanco-Quirósa, S. Muntióna et al.] // Respir. Med. – 2006. – Vol.100, №6. – P. 1072-1078.


Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Journal of Education, Health and Sport formerly Journal of Health Sciences



Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)