Влияние токсиканта делагила на морфологические изменения в слизистой оболочке полости рта крыс при разном уровне поступления алиментарных полифенолов = The influence of the toxicant delagil on the morphological changes in the oral mucosa of rats in the different levels of receipts of alimentary polyphenols

Oleh Anatolievich Glazunov, Svetlana Aleksandrovna Glazunova, Victoria Evgenievna Moroz

Abstract


Glazunov O. A., Glazunova S. A., Moroz V. E. Влияние токсиканта делагила на морфологические изменения в слизистой оболочке полости рта крыс при разном уровне поступления алиментарных полифенолов = The influence of the toxicant delagil on the morphological changes in the oral mucosa of rats in the different levels of receipts of alimentary polyphenols. Journal of Education, Health and Sport. 2015;5(12):326-332. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35466

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A326-332

http://pbn.nauka.gov.pl/works/682259

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive

 

Deklaracja.

Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.

Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).

© The Author (s) 2015;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 10.11.2015. Revised 15.12.2015. Accepted: 17.12.2015.

 

УДК: (579.23 – 036.632+615.372): 616.311:599.323.4

UDC: (579.23 – 036.632+615.372): 616.311:599.323.4

 

 

Влияние токсиканта делагила на морфологические изменения в слизистой оболочке полости рта крыс при разном уровне поступления алиментарных полифенолов

 

THE INFLUENCE OF THE TOXICANT DELAGIL ON THE MORPHOLOGICAL CHANGES IN THE ORAL MUCOSA OF RATS IN THE DIFFERENT LEVELS OF RECEIPTS OF ALIMENTARY POLYPHENOLS

 

Глазунов О. А., Глазунова С. А., Мороз В. Е.

Glazunov O. A., Glazunova S. A., Moroz V. E.

 

Днепропетровская медицинская академия МОЗ Украины,

Стоматологическая поликлиника № 1 г. Кривой Рог

Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine,

Stomatologic polyclinic number 1 of the Krivoy Rog

 

Реферат

В опытах на 22 белых крысах линии Вистар изучено влияние токсиканта делагила на морфологические изменения слизистой оболочки полости рта крыс в условиях нормального поступления и лишения животных растительной пищи. Введение на фоне полноценного рациона вивария вызвало на поверхности эпителиального пласта появление гигантских эпителиоцитов и отека в межклеточных пространствах. Хроническое лишение крыс алиментарных растительных полифенолов усиливало чувствительность слизистой оболочки полости рта к действию делагила и вызывало более значительные изменения в эпителиальном пласте и в соединительной ткани собственной пластинки слизистой оболочки щеки крыс.

 

Ключевые слова: делагил, алиментарная недостаточность полифенолов, эпителиальный пласт, гигантские эпителиоциты, митотические процессы, соединительная ткань собственной пластинки, деструктивно-воспалительные изменения, белые крысы.

 

 

 

Summary

The Aim of  study was to investigate the the influence of delagila on the morphological changes in the connective tissue of the lamina propria and the epithelium of the buccal mucosa of rats under conditions of normal receipts and deprivation of the animals plant foods.

Materials and methods. In the experiment were taken 22 white rats, distributed in the following groups. 1st group (7 rats) - intact; 2nd group (7) was obtained delagil per os at a dose of 5 mg / kg body weight of rats 5 times a week, against full vivarium ration. Rats of group 3 (8) was prepared delagil with the content on their diet, devoid of plant food. Time of the experiment was 60 days.

Results and conclusions. The introduction on the background of a full ration of vivarium caused on the surface of the epithelial layer appearance of a gigant epithelial cells and swelling in the intercellular spaces. Chronic nutritional deprivation ratsof the plant polyphenols increased the sensitivity of the oral mucosa to the action delagila and caused a significant change in the epithelial layer of connective tissue in the lamina propria of the buccal mucosa of rats.

 

Key words: delagil, nutritional deficiency of polyphenols, epithelial layer, giant epithelial cells, mitotic process, the connective tissue of the lamina propria, destructive and inflammatory changes, white rats.


Keywords


delagil; nutritional deficiency of polyphenols;epithelial layer; giant epithelial cells; mitotic process; the connective tissue of the lamina propria; destructive and inflammatory changes; white rats.

Full Text:

PDF (Russian)

References


Cписок литературы

Blay I., Brown K. D. Functional reseptors for epidermal growth factor in an epithelial-cell line derived from the rat small intestine / I. Blay, K. D. Brown // Biochem. J. – 1985. – V.225. – P.85-94.

Прохончуков А. А. Руководство по терапевтической стоматологии / А. А. Прохончуков, Н. К. Жижина // Под ред. А. И. Евдокимова. – М.: Медицина, 1967 – 572 с.

Меркулов Г.А. Курс патологической техники / Г.А. Меркулов // Л. – 1969. – 423 с.

REFERENCES:

Blay I., Brown K. D. Functional reseptors for epidermal growth factor in an epithelial-cell line derived from the rat small intestine / I. Blay, K. D. Brown // Biochem. J. – 1985. – V.225. – P.85-94.

Prokhonchukov A.A., Zhizhina N.K. Rukovodstvo po terapevticheskoy stomatologii [Manual of the therapeutic dentistry], Moscow: Meditsina, 1967, 572 p.

Merkulov G. A. Kurs patologicheskoy tekhniki [The course of the pathological technology], Leningrad: Lengis, 1969, 423 p.


Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Journal of Education, Health and Sport formerly Journal of Health Sciences



Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)