Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and Adrenaline impact after Mexidol administration

Kateryna Aleksevych, Lydmila Fira, Oleh Hrymaluck, Angela Shtroblya

Abstract


Aleksevych K. O., Fira L. S., Hrymalyuk O. I., Shtroblya A. L. Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and Adrenaline impact after Mexidol administration. Journal of Education, Health and Sport. 2015;5(3):269-278. ISSN 2391-8306. DOI: 10.5281/zenodo.16439

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A269-278

https://pbn.nauka.gov.pl/works/550559

http://dx.doi.org/10.5281/zenodo.16439

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive

 

Deklaracja.

Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.

Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).

© The Author (s) 2015;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.

 

UDC 599.32+615.9.]-092.4

RESEARCH OF FREE RADICAL AND TISSUE ENERGY SUPPLY PROCESSES ON RATS SUBJECTED TO CONCURRENT TETRACHLORMETHANE AND ADRENALINE IMPACT

AFTER MEXIDOL ADMINISTRATION

 

Aleksevych K. O.1, Fira L. S.1, Hrymalyuk O. I.1, Shtroblya A. L.2

 

1State Higher Educational Institution I.Ya. Horbachevsky Ternopil State Medical University, Ministry of Public Health, Ukraine

2State Higher Educational Institution Yzhhorod National University, Ukraine

 

Summary

 

Experiments on rats subjected to simultaneous impact of tetrachlormethane and increased adrenaline doses, revealed activated protein oxidative modification and lipoperoxidation. This caused suppression of tissue energy supply that is confirmed by decreased cytochrome oxidase and succinate dehydrogenase. The detected disorders were found to induce cardiocyte cytolysis, indicated by increased blood serum kreatine phosphokinase and lactate dehydrogenase activity alongside with its decrease in rats’ myocardium after the impact. Mexidol, used as an antioxidant, revealed positive influence on free radical oxidation processes as well as on the    normalization of myocardial bioenergetics.

 

Key words: tetrachlormethane, adrenaline, protein oxidative modification, lipoperoxidation, energy supply, Mexidol.


Keywords


tetrachlormethane, adrenaline, protein oxidative modification, lipoperoxidation, energy supply, Mexidol

Full Text:

PDF

References


Дубинина Е.Е. Окислительная модификация белков сыворотки крови человека. Метод её определения / Е.Е. Дубинина, С.О. Бурмистров, Д.А.Ходов, И.Г.Поротов // Вопросы мед. химии. – Т.41, №1. – 1995. – С. 24-26.

Етика лікаря та права людини: положення про використання тварин у біомедичних дослідах // Експериментальна та клінічна фізіологія та біохімія. – 2003. – Т. 22, № 2. – С. 108-109.

Ігрунова К.М. Корекція енергообміну при патології міокарда / К.М.Ігрунова, Л.П. Ігрунов // Експериментальна та клінічна ензимологія.- Львів. -1995. – С. 160-161.

Інструкція з використання набору реагентів для визначення загальної активності креатинкінази в сироватці, плазмі крові «Креатинкіназа-кін. СпЛ». – Погоджено МОЗ України. – 2009.

Інструкція до набору реактивів для визначення загальної активності лактатдегідрогенази (ЛДГ) (кінетичний УФ метод). – 2011.

Лапач С.Н. Статистические методи в медикобиологических исследованиях с использованием Exel / С.Н.Лапач, А.В.Чубенко, П.Н.Бабич.-К.: Морион, 2000. – 320 с.

Прохорова М.И. Методы биохимических исследований. – Л.: Изд-во ЛГУ, 1982. – 168 с.

Рыболовлев Ю. Р. Дозирование веществ для млекопитающих по константам биологической активности / Ю. Р. Рыболовлев, Р. С. Рыболовлев // Доклады АН СССР. – 1979. – Т. 247, №6. – С. 1513-1516.

Стальная И.Д., Гаришвили Т.Г. Метод определения малонового диальдегида с помощью тиобарбитуровой кислоты/ В кн.: Современные методы в биохимии/ под. ред. В.Н. Ореховича. - М.: Медицина. - 1977.- С. 66–68.

Стефанов О. В. Доклінічні дослідження лікарських засобів : під ред. О. В. Стефанова. – К. : ВД «Авіцена», 2001. – 528 с.

Хара М.Р. Динаміка показників гліколізу, ПОЛ та АОС у самців і самок щурів з адреналіновою міокардіодистрофією / М.Р. Хара // Мед. хім. – 2002. – Т. 4, № 4. – С. 73-75.

European convention for the protection of vertebrate animals used for experiment and other scientific purposes. – Council of Europe, Strasburg, 1986. – 56 p.

Ph. Gabriel Steg, Stefan K. James, Dan Atar, Luigi P. Badano, Carina Blomstrom-Lundqvist, Michael A. Borger, Carlo Di Mario, Kenneth Dickstein, Gregory Ducrocq, Francisco Fernandez-Aviles, Anthony H. Gershlick et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation European Heart Journal. – 2012. - № 33. – Р. 2569–2619.

Widimsky P., Wijns W., Fajadet J., de Belder M., Knot J., Aaberge L., Andrikopoulos G., Baz J.A., Betriu A., Claeys M., Danchin N., Djambazov S., Erne P., Hartikainen J., Huber K., Kala P., Klinceva M., Kristensen S.D., Ludman P., et al / Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J.- 2010. - № 31. – Р. 943–957.

World Health Organization Fact sheet N8310, updated May 2014, http://www.who.int/mediacentre/ factsheets/fs310/en/index.html.


Refbacks

  • There are currently no refbacks.




Copyright (c)



Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)